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Action of Lh and Fsh (show BRD2 Proteins) signaling is redundant in that either alone can support zebrafish spermatogenesis.
FSH (show BRD2 Proteins)-deficient zebrafish (fshb(-/-)) were surprisingly fertile in both sexes; however, the development of both the ovary and testis was significantly delayed.
zfFSHbeta promoter responded to 6h of gonadotropin-releasing hormone treatment by activating calcium influx and protein kinase C (PKC), but after 24h, GnRH induction was generated by activation of extracellular-regulated kinase 1/2 and repression by PKC.
LHbeta (show LHB Proteins) and LH-R (show LHCGR Proteins) mRNA expression might be involved in initial maturation events of gametes, at least in males, while the gradually increase of FSH-R (show FSHR Proteins) mRNA coincided with the advancing process of gamete maturation in both sexes
A major regulatory mechanism for FSH (show BRD2 Proteins) glycosylation involves control of beta-subunit (show POLG Proteins) N-glycosylation, possibly by inhibition of oligosaccharyl transferase. Two primate species exhibited the same all-or-none pattern of pituitary FSHbeta glycosylation.
the in vivo bioactivities of FSH (show BRD2 Proteins) glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated.
These mice showed an increase in FSH (show BRD2 Proteins) levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin (show LEP Proteins)-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice.
GnRH (show GNRH1 Proteins) stimulated the secretion of the VGF (show VGF Proteins)-derived peptide NERP1 (show VGF Proteins). NERP1 (show VGF Proteins) caused a concentration-dependent decrease in Fshb gene induction.
the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb (show LHB Proteins)), follicle stimulating hormone beta (Fshb), and intracellular adhesion molecule (show NCAM1 Proteins)-5 (Icam5 (show ICAM5 Proteins)) in females but only decreased expression of Icam5 (show ICAM5 Proteins) in males.
GnRH (show GNRH1 Proteins) stimulation of Fshb expression is dependent on miR (show MLXIP Proteins)-132/212 and involves a SIRT1 (show SIRT1 Proteins)-FOXO1 (show FOXO1 Proteins) pathway.
results suggest that FOXO1 (show FOXO1 Proteins) binding to the proximal Fshb promoter as well as FOXO1 (show FOXO1 Proteins) interaction with SMAD3 (show SMAD3 Proteins)/4 proteins may result in decreased activin induction of Fshb in gonadotropes
SCGB3A2 (show SCGB3A2 Proteins) regulates FSH (show BRD2 Proteins)/LH production in the anterior pituitary lobe.
Data suggest that the BMP2 (show BMP2 Proteins)-like Activin A (show INHBA Proteins)/BMP2 (show BMP2 Proteins) chimera AB215 regulates follicle stimulating hormone beta (FSHbeta) induction in LbetaT2 gonadotroph cells due to its ability to block activin A (show INHBA Proteins) signaling.
Two regions of the proximal Fshb promoter (-50/-41 and -30/-21) appear to be necessary for FOXO1 (show FOXO1 Proteins) suppression of GnRH (show GNRH1 Proteins)-induced Fshb transcription.
Genetic variation affecting FSH (show BRD2 Proteins) production (FSHB c.-211G>T) was associated with age at pubertal onset, as assessed by testicular enlargement. The effect appeared further modified by coexistence of genetic variation affecting FSH (show BRD2 Proteins) sensitivity (FSHR (show FSHR Proteins) c.-29G>A).
A novel homozygous mutation in the FSHbeta gene (c.343C > T) identified in a male patient with isolated FSH (show BRD2 Proteins) deficiency and infertility.
Association of the FSHB 211G > T polymorphism with male infertility in Han-Chinese
Genetic variations of FSH (show BRD2 Proteins) signaling appear to determine the individual set point of the hypothalamic-pituitary-gonadal axis already early in life.
Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency
Variants in FSHB gene are associated with polycystic ovary syndrome and LH levels in Han Chinese women.
Data indicate that compared with normal eggs, oocytes with a brown zona pellucida (ZP) were found to have a higher ZP thickness (ZPT), lower embryo quality and lower pregnancy rate, which might be due to a high gonadotropin (Gn) dosage injection and high serum follicle stimulating hormone (FSH (show BRD2 Proteins)) levels.
genetic association studies in peripubertal girls in Denmark: Data suggest that an SNP in FSHR (follicle stimulating hormone receptor (show FSHR Proteins), c.2039A>G) is associated with blood levels of FSH (show BRD2 Proteins), LH, and estradiol; minor alleles in FSHB (follicle stimulating hormone beta subunit, c.-211G>T) and FSHR (show FSHR Proteins) (c.-29G>A) are associated with delayed pubertal onset.
The FSHB -211G>T variant attenuates serum FSH (show BRD2 Proteins) levels in the supraphysiological gonadotropin setting of Klinefelter syndrome
Study describes generation and characterization of a new Fshb-iCre deleter strain using 4.7 kb of ovine Fshb promoter sequences driving iCre expression exclusively in the gonadotrope lineage with mice developing normally, and fertile.
the novel cis (show CISH Proteins)-regulatory element generated by the c.-1539_-1538delGGinsTTAACT mutations might play an important role in repressing FSHB transcription, possibly leading to reduced fertility
A 200-base region in the bovine FSHbeta 3' untranslated region downregulates reporter expression at the translational level via interactions between AREs in both the 3'UTR and transfactors.
The shift in FSH (show BRD2 Proteins) isoforms toward a greater abundance of the less acidic isoforms appears to be a key component in determining the capability for producing a preovulatory rise in estradiol.
The effect of a single nucleotide polymorphism of the follicle stimulating hormone beta chain on bull fertility and semen quality is reported.
As in vitro experiments in the present study suggested that LHX2 (show LHX2 Proteins) regulated the expression of Fshbeta, it is possible that LHX2 (show LHX2 Proteins) controls FSH (show BRD2 Proteins) synthesis at the transcriptional level.
Results showed that the effects of FSHb, ESR (show ESR1 Proteins), and PRLR (show PRLR Proteins) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
LHX3 (show LHX3 Proteins) LIM homeodomain (show LHX2 Proteins) transcription factor is involved in activation of the FSH beta-subunit (show POLG Proteins) gene in the pituitary gonadotrope cell.
Prop-1 (show PROP1 Proteins) participates in the regulation of FSHbeta gene
A allele of FSHbeta-1 locus in all the population and FSHbeta-2 locus in pigs of the first parity had the positive effective on TNB, NBA, and WB.
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.
, Gth I
, follicle-stimulating hormone beta subunit
, follitropin subunit beta
, FSH beta
, follcle-stimulating hormone beta subunit
, follicle stimulating hormone, beta polypeptide
, follitropin beta chain
, Follicle-stimulating hormone beta subunit
, follicle stimulating hormone beta-subunit
, follitropin, beta chain
, follicle - stimulating hormone subunit beta
, follicle stimulating hormone beta
, follicle-stimulating hormone beta-subunit
, follicle-stimulating hormone subunit beta
, class 1 follicle-stimulating hormone beta polypeptide
, class 2 follicle-stimulating hormone beta polypeptide
, follicule stimulating hormone, beta polypeptide
, follicle stimulating hormone beta subunit
, follitropin beta subunit