Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
KIF5B gene rearrangement plays a role in the pathogenesis of papillary thyroid cancer.
compared to those of brain, on MCF7 microtubules, kinesin-1's processivity is significantly reduced although its velocity is only slightly altered
these observations identify a previously unappreciated role for KIF5B in mediating the Nup358 (show RANBP2 ELISA Kits) dependent nuclear import of the HIV-1 viral genome during infection.
For Fat3, the Kif5 (show KIF5A ELISA Kits)-ID is regulated by alternative splicing, and the timecourse of splicing suggests that the distribution of Fat3 may switch between early and later stages of retinal development. In contrast, P75NTR (show NGFR ELISA Kits) binding to Kif5B is enhanced by tyrosine phosphorylation and thus has the potential to be dynamically regulated on a more rapid time scale
Data suggest that light-chain subunits/fragments of kinesin-1 inhibit the pathological aggregation of amyloid(beta).
In this work, we performed normal mode analysis with elastic network model using different conformation of kinesin to determine the effect of tail binding.
KIF5B is essential for Ostm1 (show OSTM1 ELISA Kits) intracellular dispersion.
differences between the structural kinetics of Eg5 (show KIF11 ELISA Kits) and kinesin-1 yield insights into how these two motors adapt their enzymologies for their distinct functions
data suggest one-step screening platform for KIF5B-RET (show RET ELISA Kits) as well as EGFR (show EGFR ELISA Kits), K-RAS (show HRAS ELISA Kits), ALK (show ALK ELISA Kits) oncogenic mutations be necessary for lung adenocarcinoma patients
Kinesin-1 is primarily front-head gated, and its neck linker length is tuned to enhance unidirectional processivity and velocity.
It was concluded that selective deletion of Kif5b in adipose tissue exacerbates HFD-induced obesity and its associated metabolic disorders, partly through a decrease in energy expenditure, dysregulation of adipokine secretion, and insulin (show INS ELISA Kits) signaling.
PI3K-dependent formation of a kinesin-1/Slp3/Rab27b (show RAB27B ELISA Kits) complex is critical for the microtubule-dependent movement of secretory granules required for mast cell degranulation.
The KIF5B level was up-regulated during 3T3-L1 adipogenesis. This increase in cytosolic KIF5B was synchronized with the induction of adiponectin (show ADIPOQ ELISA Kits). Endogenous KIF5B and adiponectin (show ADIPOQ ELISA Kits) were partially colocalized at the peri (show POSTN ELISA Kits)-nuclear and cytosolic regions.
results indicate that NCAM (show NCAM1 ELISA Kits) is delivered to the cell surface through a kinesin-1-mediated transport mechanism in a PAK1 (show PAK1 ELISA Kits)-dependent manner.
Kif5b expression during mouse kidney development
we showed that the KIF5B-RET (show RET ELISA Kits) fusion gene is oncogenic in lung alveolar epithelial cells in vivo.
nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
KIF5B is critical in suppressing chromosomal instability at the early stages of female meiotic cell development and mitotic cell division.
These results suggest that while the KLC (show KLC1 ELISA Kits) binding domain may directly targets Kif5b to the myonuclear membrane, the autoinhibitory peptide may play an indirect role in regulating the kinesin-1-mediated myonuclear positioning
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).
kinesin heavy chain
, kinesin-like protein KHC
, Kinesin heavy chain
, kinesin heavy chain isoform 5A
, kinesin family member 5B
, kinesin family member 5A
, kinesin-1 heavy chain
, conventional kinesin heavy chain
, kinesin 1 (110-120kD)
, ubiquitous kinesin heavy chain
, kinesin heavy chain member 5B, ubiquitous