Browse our RAB27A Proteins (RAB27A)

Full name:
RAB27A, Member RAS Oncogene Family Proteins (RAB27A)
On www.antibodies-online.com are 17 RAB27A, Member RAS Oncogene Family (RAB27A) Proteins from 6 different suppliers available. Additionally we are shipping RAB27A Antibodies (119) and RAB27A Kits (1) and many more products for this protein. A total of 140 RAB27A products are currently listed.
Synonyms:
2210402C08Rik, 2410003M20Rik, 4933437C11Rik, ash, GS2, HsT18676, MGC80943, MGC89827, RAB27, RAB27A, RAM, zgc:114135
list all proteins Gene Name GeneID UniProt
RAB27A 5873 P51159
RAB27A 11891 Q9ERI2
RAB27A 50645 P23640

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RAB27A Proteins (RAB27A) by Origin

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Top referenced RAB27A Proteins

  1. Human RAB27A Protein expressed in Escherichia coli (E. coli) - ABIN666995 : Kuroda, Fukuda, Ariga, Mikoshiba: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. in The Journal of biological chemistry 2002 (PubMed)

More Proteins for RAB27A Interaction Partners

Human RAB27A, Member RAS Oncogene Family (RAB27A) interaction partners

  1. RAB27A, RAB27B (show RAB27B Proteins) and VPS36 (show VPS36 Proteins) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B (show RAB27B Proteins) and VPS36 (show VPS36 Proteins), with RAB27A and RAB27B (show RAB27B Proteins) being dependent on VPS36 (show VPS36 Proteins).

  2. identified small molecule inhibitors of Rab27a-JFC1 (show SYTL1 Proteins) binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (show HRB Proteins) GTPases and their effectors.

  3. MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.

  4. decreased expression of Rab27A and Rab27B (show RAB27B Proteins), especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.

  5. We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).

  6. Data suggest that microRNA miR (show MLXIP Proteins)-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC (show CALR Proteins)) by targeting RAS-related GTP-binding protein (show RAB10 Proteins) (Rab27a), indicating a novel therapeutic strategy for patients with CRC (show CALR Proteins).

  7. Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.

  8. miR (show MLXIP Proteins)-122 has a Rab27a-dependent function in the hepatitis C virus lifecycle

  9. Rab27A may be used as a valuable prognostic biomarker for colorectal carcinoma patients.

  10. Our data indicate that RAB27A expression is an independent prognostic marker for pancreatic ductal adenocarcinoma

Mouse (Murine) RAB27A, Member RAS Oncogene Family (RAB27A) interaction partners

  1. Rab27a is a possible target for intervention in inflammatory processes in which GM-CSF (show CSF2 Proteins)-dependent neutrophil priming is involved.

  2. These results suggest that the dual effector, Noc2 (show RPH3AL Proteins), regulates the transition from Rab2a (show RAB2A Proteins)-mediated granule biogenesis to Rab27a-mediated granule exocytosis.

  3. Loss of Rab3D (show RAB3D Proteins) from secretory vesicles, leading to disproportionate Rab27-to-Rab3D (show RAB3D Proteins) activity, may contribute to the enhanced release of cathepsin S (show CTSS Proteins) in tears of patients with Sjogren's syndrome.

  4. identified small molecule inhibitors of Rab27a-JFC1 (show SYTL1 Proteins) binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (show HRB Proteins) GTPases and their effectors.

  5. The Rab27A regulates CG exocytosis following MII-stage oocyte activation.

  6. MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.

  7. Given that GTP (show AK3 Proteins)- and GDP-bound Rab27a regulate exocytosis.

  8. This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 (show CACNA1D Proteins) subunit of L-type channels, leading to decreased current density and reduced VEGF-A (show VEGFA Proteins) secretion by the retinal pigment epithelium.

  9. results show that Rab27A is present in mouse pancreatic acinar cells and mainly regulates secretion through the minor-regulated pathway

  10. Rab27A deficiency shows the increased surface level of c-fms (show CSF1R Proteins), and the delayed downregulation of RANK in ashen cells, resulting in enhanced signaling of M-CSF (show CSF1R Proteins) and RANKL (show TNFSF11 Proteins).

RAB27A Protein Profile

Protein Summary

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with RAB27A

  • RAB27A, member RAS oncogene family (rab27a)
  • RAB27A, member RAS oncogene family (RAB27A)
  • RAB27A, member RAS oncogene family (rab27a-b)
  • RAB27A, member RAS oncogene family (Rab27a)
  • 2210402C08Rik protein
  • 2410003M20Rik protein
  • 4933437C11Rik protein
  • ash protein
  • GS2 protein
  • HsT18676 protein
  • MGC80943 protein
  • MGC89827 protein
  • RAB27 protein
  • RAB27A protein
  • RAM protein
  • zgc:114135 protein

Protein level used designations for RAB27A

RAB27A, member RAS oncogene family , Ras-related protein Rab-27A , rab27a, member ras oncogene family , ras-related protein Rab-27A , GTP-binding protein Ram , rab-27 , member RAS oncogene family, RAB27A , ashen , low Mr GTP-binding protein , ram p25 , RAS oncogene family member

GENE ID SPECIES
444290 Xenopus laevis
453455 Pan troglodytes
493339 Xenopus (Silurana) tropicalis
494641 Xenopus laevis
570907 Danio rerio
5873 Homo sapiens
606749 Sus scrofa
618035 Bos taurus
11891 Mus musculus
50645 Rattus norvegicus
608699 Canis lupus familiaris
415410 Gallus gallus
101086976 Felis catus
101122791 Ovis aries
100720981 Cavia porcellus
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