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anti-Rat (Rattus) SLC30A6 Antibodies:
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anti-Mouse (Murine) SLC30A6 Antibodies:
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Mouse (Murine) Polyclonal SLC30A6 Primary Antibody for WB - ABIN657523
Lyubartseva, Smith, Markesbery, Lovell: Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. in Brain pathology (Zurich, Switzerland) 2010
Show all 3 references for ABIN657523
results of this study suggested that ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients.
The results of this study showed that signi fi cant positive correlations between ZIP1 (show SLC39A1 Antibodies),ZnT1 (show SLC30A1 Antibodies), and ZnT6 in most brain in patient with Alzheimer's disease.
our results suggest that alterations in Zn transport proteins ZnT-1 (show SLC30A1 Antibodies), ZnT-4 (show SLC30A4 Antibodies) and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms
hZnT-6 is up-regulated in response to cellular zinc depletion in Raji & THP-1 (show GLI2 Antibodies) cells.
Data show that ZNT6 is extensively present in the Abeta (show APP Antibodies)-positive plaques in the cortex of human AD brains.
The cytosolic C-terminal tail of ZnT5 (show SLC30A5 Antibodies) is important for its interaction with ZnT6 as a heterodimer.
overexpression of ZnT6 causes growth inhibition, znT6 functions in zinc homeostasis and transport
Expression of zinc transporter ZnT6 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
Increased ZnT-6 immunostaining in neurons containing cytoplasmic inclusions in MCI (show MCIN Antibodies), AD, and PD suggests a role for ZnT-6 in the pathogenesis of these lesions.
Our results revealed that ZNT7 (show SLC30A7 Antibodies) immunoreactivity was abundantly expressed in the nerve cells of the mouse DRG.Double immunofluorescence labeling of ZNT7 (show SLC30A7 Antibodies) and TGN38 (show TGOLN2 Antibodies) revealed a colocalization of the two antigens in the Golgi apparatus.
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004
zinc transporter 6
, solute carrier family 30 member 6
, solute carrier family 30 (zinc transporter), member 4
, zinc transporter-like 3