E2F Transcription Factor 7 (E2F7) (N-Term) Peptide

Details for Product No. ABIN976085, Supplier: Log in to see
Protein Name
  • E2F7
  • E2F-7
  • fc43h03
  • si:dkey-217k21.2
  • wu:fc43h03
  • MGC154335
  • A630014C11Rik
  • D10Ertd739e
  • E2F transcription factor 7
  • E2F7
  • e2f7
  • LOC100357309
  • E2f7
Protein Region
N-Term
Origin
Human
3
1
1
1
1
1
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Blocked Antibody anti-E2F7 antibody (E2F Transcription Factor 7) (N-Term) (ABIN2780153)
Sequence MEVNCLTLKD LISPRQTRLD FAIEDAENAQ KENIFVDRSR MTPKTPMKNE
Characteristics This is a synthetic peptide designed for use in combination with anti-E2F7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background E2F7 is a atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. E2F7 mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. It directly represses transcription of classical E2F transcription factors such as E2F1. It acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. It plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). It is required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter.

Alias Symbols: E2f7,

Protein Size: 904
Molecular Weight 99 kDa
Gene ID 52679
NCBI Accession XP_006513945
UniProt Q6S7F2
Research Area Transcription Factors, Chromatin and Nuclear Signaling
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.