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In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
beta-amyloid protein (31-35) altered the expression of the Per1 and Per2 in the suprachiasmatic nucleus, hippocampus and heart. These findings provide experimental evidence for circadian rhythm disturbances in patients with Alzheimer's disease.
In vivo knockdown of Rfk (show RFK ELISA Kits), Riboflavin (vitamin B2) kinase essential for FAD (show FANCD2 ELISA Kits) synthesis, altered the expression rhythms of CRY1 (show CRY1 ELISA Kits), CRY2 (show CRY2 ELISA Kits), and PER1
these data support an important role for the circadian clock protein (show ARNTL ELISA Kits) PER1 in the modulation of blood pressure in a high salt/mineralocorticoid model of hypertension
Per1 knockdown leads to JNK (show MAPK8 ELISA Kits) phosphorylation, CCL2 (show CCL2 ELISA Kits) production and allodynia.
Deletion of Per1 alleviated the inhibitory effect of PPAR-gamma (show PPARG ELISA Kits) on CC chemokine receptor 2 (show CCRL2 ELISA Kits) expression, resulting in enhanced macrophage recruitment into the liver.
Rate-limiting mitochondrial enzymes that process lipids and carbohydrates accumulate in a diurnal manner and are dependent on the clock proteins PER1/2. Diurnal regulation of mitochondrial respiration was blunted in PER1/2 knockout mice.
that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 and Per2 (show PER2 ELISA Kits) genes under abnormal light-dark conditions
measured gene expression of Fos, Per1 and Sgk1 (show SGK1 ELISA Kits) 45 min after exposure to brief cold swim stress in male and female mice; stress induced a stronger increase in Fos and Per1 expression in females than males
Histone monoubiquitination by Clock-Bmal1 (show ARNTL ELISA Kits) complex marks Per1 and Per2 (show PER2 ELISA Kits) genes for circadian feedback.
Low Per1 gene expression is associated with colorectal liver metastases.
The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy. PER1 c.2884C > G polymorphism may be associated with risk of non-response to HT in postmenopausal Korean women.
ARNTL (show ARNTL ELISA Kits) and PER1 were associated with PD.
Collectively, these data show that KPNB1 (show KPNB1 ELISA Kits) is required for timely nuclear import of PER/CRY (show CRY2 ELISA Kits) in the negative feedback regulation of the circadian clock.
when overexpressed, c-MYC (show MYC ELISA Kits) is able to repress Per1 transactivation by BMAL1 (show ARNTL ELISA Kits)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (show MYC ELISA Kits) was detected in BMAL1 (show ARNTL ELISA Kits) protein complexes
Period 1 and estrogen receptor-beta (show ESR2 ELISA Kits) are downregulated in Chinese colon cancers.
Data demonstrate a role for Per1 in the transcriptional regulation of NHE3 (show SLC9A3 ELISA Kits) and SGLT1 (show SLC5A1 ELISA Kits) in the kidney.
In adipose tissue, acute sleep deprivation vs sleep increased methylation in two promoter-interacting enhancer regions of PER1
In patients with non-small cell lung cancer, loss of Per1 was correlated with poor differentiation, tumor status, high p-TNM stage and lymph node metastasis. Patients with lower expression of Per1, Per2 and Per3 had a shorter survival time.
S714G mutation in hPER1 is associated with feeding rhythms and obesity in mice.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene\; however, these variants have not been fully described.
, period homolog 1
, circadian clock protein PERIOD 1
, circadian pacemaker protein Rigui
, period circadian protein homolog 1
, Period, drosophila, homolog of
, circadian pacemaker protein RIGUI