Browse our AKT3 Proteins (AKT3)

Full name:
V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) Proteins (AKT3)
On www.antibodies-online.com are 21 V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3) Proteins from 10 different suppliers available. Additionally we are shipping AKT3 Antibodies (290) and AKT3 Kits (21) and many more products for this protein. A total of 344 AKT3 products are currently listed.
Synonyms:
AI851531, D930002M15Rik, MPPH, Nmf350, PKB-GAMMA, Pkbg, PKBgamma, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2
list all proteins Gene Name GeneID UniProt
AKT3 23797 Q9WUA6
AKT3 10000 Q9Y243
Rat AKT3 AKT3 29414 Q63484

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AKT3 Proteins (AKT3) by Origin

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Top referenced AKT3 Proteins

  1. Human AKT3 Protein expressed in Baculovirus infected Insect Cells - ABIN2003366 : Walker, Deak, Paterson, Hudson, Cohen, Alessi: Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. in The Biochemical journal 1998 (PubMed)

More Proteins for AKT3 Interaction Partners

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3) interaction partners

  1. findings provide novel insight into the neurodevelopmental role of Akt3, identify a non-redundant role for Akt3 in the development of prefrontal cortical-mediated cognitive function and show that Akt3 is potentially the dominant regulator of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling in brain

  2. these results indicate that PI3K and Akt ( Akt1 (show AKT1 Proteins)-Akt3)play distinct roles, and that PI3K stimulates Akt (show AKT1 Proteins)-independent pathways that are important for GLUT4 (show SLC2A4 Proteins) translocation.

  3. miR (show MLXIP Proteins)-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway.

  4. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Proteins)/SGK1 (show SGK1 Proteins)/Cdc42 (show CDC42 Proteins) pathway.

  5. The predominant AKT (show AKT1 Proteins) isoform in the central nervous system, AKT3, induces much more robust axon regeneration than AKT1 (show AKT1 Proteins) and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT (show AKT1 Proteins)-induced axon regeneration.

  6. Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4 (show S100A4 Proteins).

  7. In viable Akt (show AKT1 Proteins) three-isoforms conditional knockout mice, total Akt (show AKT1 Proteins) levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt3-/-)mice.

  8. untreated Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins)/Akt3 double knockout mice display significant hearing loss, indicating a role for these isoforms in normal hearing.

  9. MicroRNA-207 enhances radiation-induced apoptosis by targeting Akt3 in cochlea hair cells.

  10. Blocking Akt1 (show AKT1 Proteins) or Akt3 but not Akt2 (show AKT2 Proteins) expression prohibits cell proliferation and reprogramming.

Human V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3) interaction partners

  1. MiR (show MLXIP Proteins)-511-3p may serve as a prognostic factor and tumor suppressor in prostate cancer, very likely through inverse regulation of its downstream target gene of AKT3.

  2. Studies found AKT3 to be important in coordinating mitochondrial biogenesis with growth factor-induced increase in cellular energy demands. This isoform also plays an important role in platelet activation and thrombosis. [review]

  3. miR (show MLXIP Proteins)-29b prevents angiogenesis/tumorigenesis in breast cancer cell by targeting Akt3 and inducing VEGF (show VEGFA Proteins) and C-myc (show MYC Proteins) arrest in breast cancer cells.

  4. AKT3 expression is markedly upregulated in AKT (show AKT1 Proteins) inhibitor-resistant cells. Induction of AKT3 is regulated epigenetically by the bromodomain and extra terminal domain proteins. Importantly, knockdown of AKT3, but not AKT1 (show AKT1 Proteins) or AKT2 (show AKT2 Proteins), in resistant cells restores sensitivity to MK2206.

  5. miR (show MLXIP Proteins)-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway.

  6. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Proteins)/SGK1 (show SGK1 Proteins)/Cdc42 (show CDC42 Proteins) pathway.

  7. partial co-localization of AKT3 with AURKB (show AURKB Proteins) was observed during anaphase. Overall, this study suggests that AKT3 could repress the antiproliferative effects of AURKi, with a novel activity particularly suppressing the aneuploidy induction.

  8. A C119S Akt3 mutant was hypomorphic for all downstream phenotypes shown by wild-type Akt3. This study documents isozyme-specific and chemical redox signal-personalized physiological responses.

  9. the mitochondrial oxygen consumption rate was significantly reduced in Akt3-knockdown cancer cell lines

  10. our findings indicate that the expression levels of P-GP (show ABCB4 Proteins), MYC (show MYC Proteins), caspase-8 (show CASP8 Proteins), and AKT3 are candidate biomarkers of cell sensitivity to PLKis.

AKT3 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with AKT3

  • thymoma viral proto-oncogene 3 (Akt3)
  • v-akt murine thymoma viral oncogene homolog 3 (AKT3)
  • v-akt murine thymoma viral oncogene homolog 3 (Akt3)
  • v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (AKT3)
  • v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (akt3)
  • AI851531 protein
  • D930002M15Rik protein
  • MPPH protein
  • Nmf350 protein
  • PKB-GAMMA protein
  • Pkbg protein
  • PKBgamma protein
  • PRKBG protein
  • RAC-gamma protein
  • RAC-PK-gamma protein
  • STK-2 protein

Protein level used designations for AKT3

PKB gamma , RAC-PK-gamma , RAC-gamma serine/threonine-protein kinase , protein kinase Akt-3 , protein kinase B gamma , RAC-gamma serine/threonine protein kinase , v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) , AKT3 kinase , protein kinase B, gamma , thymoma viral proto-oncogene 3 , v-akt murine thymoma viral oncogene 3 , protein kinase B gamma-like protein , v-akt murine thymoma viral oncogene-like 3

GENE ID SPECIES
23797 Mus musculus
10000 Homo sapiens
29414 Rattus norvegicus
442964 Canis lupus familiaris
100137872 Bos taurus
421497 Gallus gallus
100513811 Sus scrofa
100127477 Sus scrofa
100149794 Danio rerio
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