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Report frequency of genetic variation in Akt3 and discuss link to disease.
AKT3 Splice Variants are associated with HPV-Positive Oropharyngeal Cancers.
Results show that AKT3 influences outcome of pneumococcal meningitis in human patients; validated the findings in a mouse experimental pneumococcal meningitis model.
High AKT3 expression is associated with triple-negative breast cancer.
This study showed that activating mutations of AKT3 are associated with a much broader spectrum of developmental brain disorders in children, with several clinical phenotypes determined partially by the type of mutation and level of mosaicism.
MiR (show MLXIP Proteins)-511-3p may serve as a prognostic factor and tumor suppressor in prostate cancer, very likely through inverse regulation of its downstream target gene of AKT3.
Studies found AKT3 to be important in coordinating mitochondrial biogenesis with growth factor-induced increase in cellular energy demands. This isoform also plays an important role in platelet activation and thrombosis. [review]
miR (show MLXIP Proteins)-29b prevents angiogenesis/tumorigenesis in breast cancer cell by targeting Akt3 and inducing VEGF (show VEGFA Proteins) and C-myc (show MYC Proteins) arrest in breast cancer cells.
AKT3 expression is markedly upregulated in AKT (show AKT1 Proteins) inhibitor-resistant cells. Induction of AKT3 is regulated epigenetically by the bromodomain and extra terminal domain proteins. Importantly, knockdown of AKT3, but not AKT1 (show AKT1 Proteins) or AKT2 (show AKT2 Proteins), in resistant cells restores sensitivity to MK2206.
miR (show MLXIP Proteins)-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway.
findings provide novel insight into the neurodevelopmental role of Akt3, identify a non-redundant role for Akt3 in the development of prefrontal cortical-mediated cognitive function and show that Akt3 is potentially the dominant regulator of AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling in brain
these results indicate that PI3K and Akt ( Akt1 (show AKT1 Proteins)-Akt3)play distinct roles, and that PI3K stimulates Akt (show AKT1 Proteins)-independent pathways that are important for GLUT4 (show SLC2A4 Proteins) translocation.
Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Proteins)/SGK1 (show SGK1 Proteins)/Cdc42 (show CDC42 Proteins) pathway.
The predominant AKT (show AKT1 Proteins) isoform in the central nervous system, AKT3, induces much more robust axon regeneration than AKT1 (show AKT1 Proteins) and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT (show AKT1 Proteins)-induced axon regeneration.
Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4 (show S100A4 Proteins).
In viable Akt (show AKT1 Proteins) three-isoforms conditional knockout mice, total Akt (show AKT1 Proteins) levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt3-/-)mice.
untreated Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins)/Akt3 double knockout mice display significant hearing loss, indicating a role for these isoforms in normal hearing.
MicroRNA-207 enhances radiation-induced apoptosis by targeting Akt3 in cochlea hair cells.
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
, RAC-gamma serine/threonine protein kinase
, RAC-gamma serine/threonine-protein kinase
, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
, protein kinase Akt-3
, protein kinase B gamma
, AKT3 kinase
, protein kinase B, gamma
, thymoma viral proto-oncogene 3
, v-akt murine thymoma viral oncogene 3
, protein kinase B gamma-like protein
, v-akt murine thymoma viral oncogene-like 3
, LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase