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Cloning and functional analysis of the bim gene.
in FOXO3 (show FOXO3 ELISA Kits)-death-resistant cells no point mutations in the TP53 (show TP53 ELISA Kits)-DBD were found-in these cells FOXO3 (show FOXO3 ELISA Kits)-TP53 (show TP53 ELISA Kits) complexes are formed and FOXO3 (show FOXO3 ELISA Kits)-binding to the BIM-promoter, but not the induction of the detoxifying protein SESN3 (show SESN3 ELISA Kits), were prevented, which in turn increased chemo-protection in this type of high-stage-derived neuroblastoma (show ARHGEF16 ELISA Kits) cells
At BCL2L11, the authors identify a haematopoietic enhancer hub that is inactivated by the Epstein-Barr virus repressors EBNA3A and EBNA3C through recruitment of the H3K27 methyltransferase EZH2 (show EZH2 ELISA Kits).
observations suggest that an association of a deletion polymorphism of BIM and the response to induction therapy in B-cell precursor acute lymphoblastic leukemia may be clinically minimal
expression of Bim is mediated by FoxO1 (show FOXO1 ELISA Kits) and indirectly downregulated by thyroid hormone/thyroid hormone (show PTH ELISA Kits) receptor (show THRA ELISA Kits), leading to chemotherapy resistance and doxorubicin-promoted metastasis of hepatoma cells.
BIM is associated with favorable prognostic markers for prediction of disease-free survival and overall survival in cervical cancer.
this study shows that BIM deletion polymorphisms are associated with a poor clinical response to erlotinib and represents an independent prognostic factor for patients with EGFR (show EGFR ELISA Kits) positive non-small-cell lung cancer
The Bim deletion polymorphism was found to be associated with primary resistance to crizotinib in patients with ALK (show ALK ELISA Kits) fusion-positive NSCLC.
increased apoptosis resistance was associated with significantly reduced up-regulation of proapoptotic Bim in T cells from patients with primary sclerosing cholangitis.
Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2 (show PON2 ELISA Kits)) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS (show ROS1 ELISA Kits)) production and induces Bim protein production that inhibits cancer progression via the PON2 (show PON2 ELISA Kits)-Bim cascade.
Little difference in Bim expression among CD20 (show MS4A1 ELISA Kits)+ cells was seen between tonsil primary follicles, tonsil germinal centers, and lupus nephritis renal tissue. The frequency of Bim-positive cells among CD4 (show CD4 ELISA Kits)+ lymphocytes was significantly lower in lupus nephritis kidneys compared to tonsil controls.
SIRT2 (show SIRT2 ELISA Kits) deacetylates Foxo3a (show FOXO3 ELISA Kits), activates Bim, and induces apoptosis only in 1-methyl-4-phenylpyridinium-treated cells
Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction.
understanding the cell autonomous role Bim plays in the retinal vascular homeostasis will give us new insight into how to modulate pathological retinal neovascularization and vessel regression to preserve vision
The central role of Bim-dependent apoptosis in Buruli Ulcer pathogenesis
we found a temporal and tissue-specific role for Bim in limiting thymic agonist selection of CD8alphaalpha precursors and their TCRbeta repertoire, but not in the maintenance of CD8alphaalpha intraepithelial lymphocytes in the intestine.
loss of the BH3-only (show BBC3 ELISA Kits) protein BIM accelerated lymphoma development in p53 (show TP53 ELISA Kits)-deficient mice. This process was negated by concomitant loss of RAG1 (show RAG1 ELISA Kits)/2-mediated antigen receptor gene rearrangement.
Overexpression of miR (show MLXIP ELISA Kits)-29 or miR (show MLXIP ELISA Kits)-24 is sufficient to inhibit the induction of Bim and Puma (show BBC3 ELISA Kits) in young sympathetic neurons.
the activation of ERK5 (show MAPK7 ELISA Kits)-AKT (show AKT1 ELISA Kits)-FoxO3a (show FOXO3 ELISA Kits) signaling pathways by fluid shear stress resulted in a decreased expression of FasL (show FASL ELISA Kits) and Bim and an inhibition of caspase-3 (show CASP3 ELISA Kits) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.
long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
Results indicate that upregulation of miR (show MLXIP ELISA Kits)-124 could regulate apoptosis and impaired autophagy process in the MPTP (show PTPN2 ELISA Kits) model of Parkinson's disease, thus reducing the loss of dopaminergic neurons
Pseudorabies virus glycoprotein gE-mediated ERK 1 (show MAPK3 ELISA Kits)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (show MAPK3 ELISA Kits)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.
BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 ELISA Kits).
It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
, Bcl-2 interacting mediator of cell death
, bcl-2 interacting mediator of cell death
, bcl-2 interacting protein Bim
, bcl-2-like protein 11
, bcl-2-related ovarian death agonist
, Bcl2 interacting mediator of cell death
, bcl2-interacting mediator of cell death
, Bcl-2 related apoptotic gene product BimL
, bcl-2-related ovarian death protein