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Cloning and functional analysis of the bim gene.
mRNA expression of BIM and MTOR (show FRAP1 ELISA Kits) in 57 patients with EGFR (show EGFR ELISA Kits)-mutant non-small-cell lung cancer.
miR (show MLXIP ELISA Kits)-24 promotes tumor growth and angiogenesis by suppressing Bim expression in a model of pancreatic carcinoma
miR (show MLXIP ELISA Kits)-181b/Bim pathway may be a novel target used to overcome the chemoresistance in breast cancer
Bcl-2 (show BCL2 ELISA Kits) dependent NB cell lines are exquisitely sensitive to ABT-199 . Treatment with ABT-199 displaces Bim from Bcl-2 (show BCL2 ELISA Kits) in NB to activate caspase 3 (show CASP3 ELISA Kits), confirming the restoration of mitochondrial apoptosis
Fluorizoline bind to prohibitin (show PHB ELISA Kits), inducing mitochondrial apoptotic pathway through NOXA (show PMAIP1 ELISA Kits) and BIM upregulation.
LA provoked a down regulation of two anti-apoptotic proteins, Mcl-1 (show MCL1 ELISA Kits) and Bcl-xL (show BCL2L1 ELISA Kits) protein and a strong induction of the BH3-only (show BBC3 ELISA Kits) protein Bim.
JNK/c-Jun activation and BIM induction is a late pro-apoptotic response of glioma cells treated with alkylating anticancer drugs.
analysis of the intricate network regulating Bim activity and its involvement in physiological and pathophysiological processes [review]
Review/Meta-analysis: BIM deletion polymorphism was associated with poor response in NSCLC patients who received EGFR (show EGFR ELISA Kits)-TKIs treatment.
Low expression of pro-apoptotic Bim protein in in Waldenstrom macroglobulinemia.
Rapid activation of AMPK (show PRKAA1 ELISA Kits) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (show STK11 ELISA Kits) activation but not increased intracellular AMP (show TMPRSS5 ELISA Kits) levels or CaMKKbeta activation.
Consistent with a contribution of BCL2 (show BCL2 ELISA Kits) family proteins to the second wave of cell death during involution, loss of Bim reduced the number of apoptotic cells in this irreversible phase
The current study demonstrated that the BH3-only (show BBC3 ELISA Kits) protein, Bim, might regulate a subset of inflammatory cells in the gastric mucosa during H. pylori-mediated gastritis.
Bcl2 interacting mediator of cell death (Bim) and Bcl2 modifying factor (Bmf (show BMF ELISA Kits)), mediate apoptosis in the context of TACI (show TNFRSF13B ELISA Kits)-Ig overexpression that effectively neutralizes BAFF (show TNFSF13B ELISA Kits) as well as APRIL.
these results indicate that 1alpha,25(OH)2D3 and TX 527 trigger apoptosis by Bim protein increase which turns into the activation of caspase-3 (show CASP3 ELISA Kits) in SVEC and vGPCR cells
miR (show MLXIP ELISA Kits)-155 regulates the delicate balance between PAK1 (show PAK1 ELISA Kits)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
The findings reveal an essential role for TRIM33 (show TRIM33 ELISA Kits) in preventing apoptosis in B lymphoblastic leukemia by interfering with enhancer-mediated Bim activation.
BIM deficiency prevents diabetes in NOD mice by diverting thymocytes to Treg cells via reduced thymic deletion.
with age, enhanced ICOS (show ICOS ELISA Kits) expression on eTregs likely limits Bim expression via activation of the PI3K/Akt (show AKT1 ELISA Kits)/FOXO (show FOXO3 ELISA Kits) pathway, promoting eTreg survival.
BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (show GDF9 ELISA Kits).
It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
, Bcl-2 interacting mediator of cell death
, bcl-2 interacting mediator of cell death
, bcl-2 interacting protein Bim
, bcl-2-like protein 11
, bcl-2-related ovarian death agonist
, Bcl2 interacting mediator of cell death
, bcl2-interacting mediator of cell death
, Bcl-2 related apoptotic gene product BimL
, bcl-2-related ovarian death protein