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Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (show CDK2AP1 ELISA Kits)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 (show MBD3 ELISA Kits) to the promoter region of Wnt (show WNT2 ELISA Kits) signaling genes
Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity.
identified a mitogen-activated protein kinase (show MAPK1 ELISA Kits) partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption
Here, we introduce a transcriptional signature to specifically track CDK2 (show CDK2 ELISA Kits) activity. It responds to genetic and chemical perturbations in the CDK (show CDK4 ELISA Kits)-RB-E2F (show E2F1 ELISA Kits) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (show CDK2 ELISA Kits) activity during cell cycle progression
Here, we found that centrosomal protein of 76 kDa (Cep76 (show Cep76 ELISA Kits)), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2 (show CDK2 ELISA Kits)) and is a bona fide substrate of this kinase. Cep76 (show Cep76 ELISA Kits) is preferentially phosphorylated by cyclin A (show CCNA2 ELISA Kits)/CDK2 (show CDK2 ELISA Kits) at a single site S83, and this event is crucial to suppress centriole amplification in S phase
The authors find that Spy1 (show SPDYA ELISA Kits) confers structural changes to Cdk2 (show CDK2 ELISA Kits) that obviate the requirement of Cdk (show CDK4 ELISA Kits) activation loop phosphorylation.
CDK2 (show CDK2 ELISA Kits) serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
Date show that when Wee1 (show WEE1 ELISA Kits) alone is inhibited, Chk1 (show CHEK1 ELISA Kits) suppresses CDC45 loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (show CDK4 ELISA Kits)-activity.
Results show that cyclin E1 (show CCNE1 ELISA Kits) and CDK2 (show CDK2 ELISA Kits) participate in STC1 (show STC1 ELISA Kits) promoting cell proliferation of prostate neoplasm cells.
The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 (show CDK2 ELISA Kits) disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 (show CDK1 ELISA Kits) inhibition.
periodic phosphorylation of Ku70 (show XRCC6 ELISA Kits) by cyclin-cyclin (show PCNA ELISA Kits) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.
a SUMO-deficient Rb mutant results in reduced SUMOylation and phosphorylation, weakened CDK2 (show CDK2 ELISA Kits) binding, and attenuated E2F-1 (show E2F1 ELISA Kits) sequestration.
These two states are separated by different metastable states that share hybrid structural features with both forms of the kinase. In contrast, the CDK2/ANS complex landscape is compatible with a conformational selection picture where the binding of ANS in proximity of the alphaC helix causes a population shift toward the inactive conformation
This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene.
cyclin-dependent kinase 2-associated protein 2
, DOC-1 related protein
, DOC-1-related protein
, cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, CDK2-associated protein 2
, tumor suppressor deleted in oral cancer related 1
, tumor suppressor deleted in oral cancer-related 1