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Our findings suggest that alteration of p16, p14 (show S100A9 Proteins), p27 (show PAK2 Proteins), p21 (show CDKN1A Proteins), and p53 (show TP53 Proteins) status may contribute to carcinogenesis and the clinical behavior of HPV-negative adenocarcinoma of the uterine cervix
antitumor effects of DOC-1R may be mediated by negatively regulating G1 phase progression and G1/S transition through inhibiting CDK2 (show CDK2 Proteins) expression and activation
Cdk2ap2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (show CDK2AP1 Proteins)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 (show MBD3 Proteins) to the promoter region of Wnt (show WNT2 Proteins) signaling genes
Mouse DOC-1R gene can significantly inhibit cell growth and colony formation capacity.
identified a mitogen-activated protein kinase (show MAPK1 Proteins) partner, DOC1R, a murine homologue of a potential human tumor suppressor gene; characterized DOC1R during mouse oocyte meiosis resumption
This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene.
CDK2-associated protein 2
, DOC-1-related protein
, cyclin-dependent kinase 2-associated protein 2
, tumor suppressor deleted in oral cancer related 1
, tumor suppressor deleted in oral cancer-related 1
, DOC-1 related protein