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Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (show CDK2 ELISA Kits) or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 (show WEE1 ELISA Kits) inhibition in pancreatic cancers.
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (show CDKN1A ELISA Kits), p27 (show PAK2 ELISA Kits)-cyclin E (show CCNE1 ELISA Kits),A/Cdk2 (show CDK2 ELISA Kits) pathway.
On analyzing cyclin A and B1 (CCNA and CCNB1 (show CCNB1 ELISA Kits)) expression, positive staining in 90% cases of PTC (show F9 ELISA Kits) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (show F9 ELISA Kits).
Study describes a positive feedback loop centred on cyclin A2-Cdk2 (show CDK2 ELISA Kits) inhibition of interphase APC (show APC ELISA Kits)/C-Cdc20 (show CDC20 ELISA Kits) to allow further cyclin A2 accumulation and mitotic entry.
PIWIL2 (show PIWIL2 ELISA Kits) has a role in promoting progression of non-small cell lung cancer by inducing CDK2 (show CDK2 ELISA Kits) and Cyclin A expression
Cyclin A2-binding function of pUL21a contributes to the maintenance of a cell cycle state conducive for the completion of the human cytomegalovirus (HCMV) replication cycle.
HDAC10 (show HDAC10 ELISA Kits) regulates cyclin A2 expression by deacetylating histones near the let-7 promoter.
Results suggest that cyclin A2 overexpression may drive cancer by promoting AKT (show AKT1 ELISA Kits)-dependent proliferation and survival.
for the first time, we demonstrated that CTD induced G2/M phase arrest via the inhibition of Cdc25c (show CDC25C ELISA Kits) and cyclin A and induced apoptosis was through death receptor (extrinsic), intrinsic (mitochondria) and ER stress pathways in A375. S2 cells.
CCN2 (show CTGF ELISA Kits) is a regulator of the transition through cytokinesis during terminal erythropoiesis.
hese data suggest that mmu-miR (show MLXIP ELISA Kits)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K (show EEF2K ELISA Kits) and CCNA2 expression.
Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin (show CTNNB1 ELISA Kits) and phospholipase C (show PLC ELISA Kits) pathways.
Ccn2 (show CTGF ELISA Kits) is a regulator of the transition through cytokinesis during terminal erythropoiesis.
Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination.
Data indicate that cyclin A2-depleted epithelial cells adopt a fibroblastic morphology and undergo epithelial to mesenchymal transition (EMT (show ITK ELISA Kits)).
The activity of PCTK3 (show CDK18 ELISA Kits) is increased via interaction with cyclin A2 and phosphorylation by PKA.
AMPKalpha1 (show PRKAA1 ELISA Kits) controlled cyclin A2 transcription mainly through the ATF/CREB (show CREB1 ELISA Kits) element
Loss of Cdk2 (show CDK2 ELISA Kits) and cyclin A2 impairs cell proliferation and tumorigenesis.
Conditional knockout of cyclin A2 or the SHH (show SHH ELISA Kits) proliferative target Nmyc (show MYCN ELISA Kits) in CGNP also resulted in PC neuron dyslamination
decreased miR (show MLXIP ELISA Kits)-124 expression could increase CCNA2 in cell and animal model of HD and is involved in deregulation of cell cycle in STHdh(Q111)/Hdh (show HTT ELISA Kits)(Q111) cells
B-Myb (show MYBL2 ELISA Kits) represses SMC (show DYM ELISA Kits) elastin (show ELN ELISA Kits) gene expression and cyclin A plays a role in the developmental regulation of elastin (show ELN ELISA Kits) gene expression in the aorta
inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation
an essential role for UHRF1 (show UHRF1 ELISA Kits) phosphorylation by cyclin-dependent kinase 2 (show CDK2 ELISA Kits)/cyclin A2 during early vertebrate development
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
, cyclin A
, cyclin A2
, Cyclin A2 (Cyclin A)