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Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2.
Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin (show BIRC5 ELISA Kits) expression
Data suggest that DEPTOR has a tumor suppressive activity against pancreatic cancer cells, and its loss of expression may contribute to pancreatic tumorigenesis.
Data indicate that phosphatidic acid (PA) specifically disrupts DEPTOR-mTORC1 interaction.
conclude that DEPTOR-related mTOR (show FRAP1 ELISA Kits) suppression is involved in metformin's anti-cancer action in liver, and could be a novel target for anti-cancer therapy
our data provide evidence for the requirement of TGFbeta (show TGFB1 ELISA Kits)-activated mTORC1 only by deptor downregulation, which dominates upon the bystander mTORC2 (show CRTC2 ELISA Kits) activity for enhanced expression of collagen I (alpha2).
In Alzheimer's disease patients the mTOR (show FRAP1 ELISA Kits) pathway can be overactive, leading to a dysfunction of autophagy and a lack of amyloid beta clearance so the excess of amyloid beta will cause a further decrease in DEPTOR and an increase in mTOR (show FRAP1 ELISA Kits) expression.
Receptor CXCR4 (show CXCR4 ELISA Kits) signaling promotes lysosomal and ESCRT-dependent degradation of DEPTOR, an antagonist of mTORC2 (show CRTC2 ELISA Kits), that regulates Akt (show AKT1 ELISA Kits) activation and signaling.
Downregulation of DEPTOR (p=0.331) in CRC (show CALR ELISA Kits).
DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR (show FRAP1 ELISA Kits) activity in undifferentiated embryonic stem cells
p38gamma (show MAPK12 ELISA Kits) and p38delta (show MAPK1/3 ELISA Kits) control heart growth by modulating mTOR (show FRAP1 ELISA Kits) pathway through DEPTOR phosphorylation and subsequent degradation.
DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.
Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR (show FRAP1 ELISA Kits) kinase substrates, 4E-BP1 (show EIF4EBP1 ELISA Kits) and S6K1 (show RPS6KB1 ELISA Kits), and concomitantly increased protein synthesis.
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4