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Association between insulin (show INS ELISA Kits) sensitivity and genetic variants in DEPTOR gene suggest DEPTOR and mammalian target of rapamycin (show FRAP1 ELISA Kits) signaling pathway to be potential target for future research and pharmacological interventions.
High DEPTOR expression is associated with T-cell leukemia.
Results provide evidence that DEPTOR acts as a tumor suppressor by limiting EGFR (show EGFR ELISA Kits)-driven lung adenocarcinoma progression.
that DEPTOR expression is required to maintain myeloma cell differentiation and high level of its expression are associated with better outcome.
High expression of DEPTOR benefits esophageal squamous cell carcinoma patients in early stage but not advanced stage.
the present findings supported the fact that DEPTOR-mTOR (show FRAP1 ELISA Kits) signaling is a central regulator of lipid metabolism-mediated inflammation in lymphocytes of PBMC culture.
In this study we began by validating the expression of four main mTOR (show FRAP1 ELISA Kits) pathway components, mTOR (show FRAP1 ELISA Kits), DEPTOR, rictor (show RICTOR ELISA Kits) and raptor (show RPTOR ELISA Kits), at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Cul1 (show CUL1 ELISA Kits) promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2.
Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin (show BIRC5 ELISA Kits) expression
These results support the idea that other neuronal populations are responsible for these phenotypes. Nonetheless, we observed a mild elevation in fasting blood glucose, insulin (show INS ELISA Kits) resistance, and alterations in liver glucose and lipid homeostasis in mice overexpressing DEPTOR in POMC (show POMC ELISA Kits) neurons. Taken together, these results show that DEPTOR overexpression in POMC (show POMC ELISA Kits) neurons does not affect energy balance regulation but could modu
The present study indicates that regulation of DEPTOR/mTOR (show FRAP1 ELISA Kits) signaling may be an important mechanism for glutamine (show GFPT1 ELISA Kits) in prevention against the development of colitis-associated colorectal cancer (CAC (show SLC25A20 ELISA Kits)): the chemopreventive effect of dietary glutamine (show GFPT1 ELISA Kits) on CAC (show SLC25A20 ELISA Kits) is, at least in part, associated with the induction of autophagy.
DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65 (show NFkBP65 ELISA Kits).
p38gamma (show MAPK12 ELISA Kits) and p38delta (show MAPK1/3 ELISA Kits) control heart growth by modulating mTOR (show FRAP1 ELISA Kits) pathway through DEPTOR phosphorylation and subsequent degradation.
DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR (show FRAP1 ELISA Kits) activity in undifferentiated embryonic stem cells
DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.
Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR (show FRAP1 ELISA Kits) kinase substrates, 4E-BP1 (show EIF4EBP1 ELISA Kits) and S6K1 (show RPS6KB1 ELISA Kits), and concomitantly increased protein synthesis.
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4