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the present findings supported the fact that DEPTOR-mTOR (show FRAP1 Proteins) signaling is a central regulator of lipid metabolism-mediated inflammation in lymphocytes of PBMC culture.
In this study we began by validating the expression of four main mTOR (show FRAP1 Proteins) pathway components, mTOR (show FRAP1 Proteins), DEPTOR, rictor and raptor (show RPTOR Proteins), at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Cul1 (show CUL1 Proteins) promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
Propose regulation of placental SNAT2 (show SLC38A2 Proteins)/LAT1 (show LAT Proteins) ubiquitination by mTORC1 and Nedd4-2 (show NEDD4L Proteins).
Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin (show BIRC5 Proteins) expression
Data suggest that DEPTOR has a tumor suppressive activity against pancreatic cancer cells, and its loss of expression may contribute to pancreatic tumorigenesis.
Data indicate that phosphatidic acid (PA) specifically disrupts DEPTOR-mTORC1 interaction.
conclude that DEPTOR-related mTOR (show FRAP1 Proteins) suppression is involved in metformin's anti-cancer action in liver, and could be a novel target for anti-cancer therapy
our data provide evidence for the requirement of TGFbeta (show TGFB1 Proteins)-activated mTORC1 only by deptor downregulation, which dominates upon the bystander mTORC2 (show CRTC2 Proteins) activity for enhanced expression of collagen I (alpha2).
In Alzheimer's disease patients the mTOR (show FRAP1 Proteins) pathway can be overactive, leading to a dysfunction of autophagy and a lack of amyloid beta clearance so the excess of amyloid beta will cause a further decrease in DEPTOR and an increase in mTOR (show FRAP1 Proteins) expression.
The present study indicates that regulation of DEPTOR/mTOR (show FRAP1 Proteins) signaling may be an important mechanism for glutamine (show GFPT1 Proteins) in prevention against the development of colitis-associated colorectal cancer (CAC (show SLC25A20 Proteins)): the chemopreventive effect of dietary glutamine (show GFPT1 Proteins) on CAC (show SLC25A20 Proteins) is, at least in part, associated with the induction of autophagy.
DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65 (show NFkBP65 Proteins).
p38gamma (show MAPK12 Proteins) and p38delta control heart growth by modulating mTOR (show FRAP1 Proteins) pathway through DEPTOR phosphorylation and subsequent degradation.
DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR (show FRAP1 Proteins) activity in undifferentiated embryonic stem cells
DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.
Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR (show FRAP1 Proteins) kinase substrates, 4E-BP1 (show EIF4EBP1 Proteins) and S6K1 (show RPS6KB1 Proteins), and concomitantly increased protein synthesis.
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4