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Cul1 (show CUL1 Proteins) promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
Propose regulation of placental SNAT2 (show SLC38A2 Proteins)/LAT1 (show LAT Proteins) ubiquitination by mTORC1 and Nedd4-2 (show NEDD4L Proteins).
Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin (show BIRC5 Proteins) expression
Data suggest that DEPTOR has a tumor suppressive activity against pancreatic cancer cells, and its loss of expression may contribute to pancreatic tumorigenesis.
Data indicate that phosphatidic acid (PA) specifically disrupts DEPTOR-mTORC1 interaction.
conclude that DEPTOR-related mTOR (show FRAP1 Proteins) suppression is involved in metformin's anti-cancer action in liver, and could be a novel target for anti-cancer therapy
our data provide evidence for the requirement of TGFbeta (show TGFB1 Proteins)-activated mTORC1 only by deptor downregulation, which dominates upon the bystander mTORC2 (show CRTC2 Proteins) activity for enhanced expression of collagen I (alpha2).
In Alzheimer's disease patients the mTOR (show FRAP1 Proteins) pathway can be overactive, leading to a dysfunction of autophagy and a lack of amyloid beta clearance so the excess of amyloid beta will cause a further decrease in DEPTOR and an increase in mTOR (show FRAP1 Proteins) expression.
Receptor CXCR4 (show CXCR4 Proteins) signaling promotes lysosomal and ESCRT-dependent degradation of DEPTOR, an antagonist of mTORC2 (show CRTC2 Proteins), that regulates Akt (show AKT1 Proteins) activation and signaling.
Downregulation of DEPTOR (p=0.331) in CRC (show CALR Proteins).
p38gamma (show MAPK12 Proteins) and p38delta control heart growth by modulating mTOR (show FRAP1 Proteins) pathway through DEPTOR phosphorylation and subsequent degradation.
DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR (show FRAP1 Proteins) activity in undifferentiated embryonic stem cells
DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.
Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR (show FRAP1 Proteins) kinase substrates, 4E-BP1 (show EIF4EBP1 Proteins) and S6K1 (show RPS6KB1 Proteins), and concomitantly increased protein synthesis.
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4