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Browse our FOXO1 Proteins (FOXO1)

Full name:
Forkhead Box O1 Proteins (FOXO1)
On are 9 Forkhead Box O1 (FOXO1) Proteins from 5 different suppliers available. Additionally we are shipping FOXO1 Antibodies (373) and FOXO1 Kits (61) and many more products for this protein. A total of 464 FOXO1 products are currently listed.
Afxh, AI876417, FKH1, Fkhr, Fkhr1, foxo1, FoxO1A, FoxO1a.1, xFoxO1, zgc:153388
list all proteins Gene Name GeneID UniProt
FOXO1 2308 Q12778
FOXO1 56458 Q9R1E0
Rat FOXO1 FOXO1 84482  

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FOXO1 Proteins (FOXO1) by Origin

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More Proteins for FOXO1 Interaction Partners

Cow (Bovine) Forkhead Box O1 (FOXO1) interaction partners

  1. downregulation of SIRT1 (show SIRT1 Proteins) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age

  2. FOXO (show FOXO3 Proteins) is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.

  3. Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Proteins)-1 mRNA.

  4. The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Proteins) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.

Human Forkhead Box O1 (FOXO1) interaction partners

  1. An oncogenic miR (show MLXIP Proteins)-9 targeted FoxO1 to promote cell growth; downregulation of this axis was involved in erlotinib's cancer cells growth inhibitory effects.

  2. The function of these FOXO (show FOXO3 Proteins) proteins in age-related diseases has been extensively studied, in the model organism Caenorhabditis elegans as well as in humans.

  3. miR (show MLXIP Proteins)-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR (show FRAP1 Proteins)-p-PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)-c-JUN (show JUN Proteins).

  4. Secreted Frizzled-Related Protein 3 (SFRP3 (show FRZB Proteins)) Is Required for Tumorigenesis of PAX3 (show PAX3 Proteins)-FOXO1-Positive Alveolar Rhabdomyosarcoma

  5. Studies indicate that forkhead box O1 protein (Foxo1) serves as a key negative checkpoint regulator at least for maturation, but may also exhibit other critical functions in NK cells.

  6. Porphyromonas gingivalis-induced reactive oxygen species activate FOXO (show FOXO3 Proteins) transcription factors through JNK (show MAPK8 Proteins) signalling, and that FOXO1 controls oxidative stress responses, inflammatory cytokine production and cell survival.

  7. Foxo1 and PDX1 are colocalized in fetal pancreatic islets, suggesting they function in parallel in beta cells. (show INS Proteins)

  8. In primary Diffuse large B-cell lymphomas, FOXO1 expression was present in 80% of tumors, correlated with SYK (show SYK Proteins) activity, and was associated with longer overall survival.

  9. demonstrated FOXO1 is a direct target of miR (show MLXIP Proteins)-135a and transcriptionally down-regulated by miR (show MLXIP Proteins)-135a

  10. Taken together, these results revealed that the upregulation of miR (show MLXIP Proteins)-370 might facilitate the repair of amputated fingers by regulating angiogenesis through targeting FOXO1.

Pig (Porcine) Forkhead Box O1 (FOXO1) interaction partners

  1. let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Proteins) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.

  2. inhibition of FoxO1 expression level caused by miR (show MYLIP Proteins)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Proteins)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

  3. Results show that FoxO1 likely regulates MyHC I (show MYH7 Proteins) negatively and MyHC IIx and MyHC IIb (show MYH4 Proteins) positively and may play a pivotal role in the determination of muscle fiber type.

  4. Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.

  5. Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.

  6. FoxO1 and C/EBPb (show CEBPB Proteins) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Proteins)-> FoxO1-> C/EBPb (show CEBPB Proteins) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Proteins) protein complex.

  7. FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.

  8. concluded that PI 3 (show PI3 Proteins)-kinase and Akt (show AKT1 Proteins) are activated after renal ischemia/reperfusion and that Akt (show AKT1 Proteins) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (show FOXO3 Proteins), which may affect epithelial cell fate in acute renal failure.

  9. FoxO1a can regulate p27kip nuclear localization

  10. FoxO1 expression level has a negative correlation with the development of muscle fiber

Mouse (Murine) Forkhead Box O1 (FOXO1) interaction partners

  1. Akt (show AKT1 Proteins)-FoxO1 signaling pathway plays an essential role during liver regeneration

  2. miR (show MLXIP Proteins)-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR (show FRAP1 Proteins)-p-PI3K/AKT (show AKT1 Proteins)-c-JUN (show JUN Proteins).

  3. FoxO1-mediated autophagy is required for NK cell development and NK cell-induced innate immunity.

  4. The 3'-untranslated region of FoxO1 contains a conserved target sequence of miR (show MLXIP Proteins)-9 and FoxO1 expression is coordinated in concert with miR (show MLXIP Proteins)-9 during neuronal differentiation.

  5. PKCdelta (show PKCd Proteins)-mediated phosphorylation of 14-3-3zeta (show YWHAZ Proteins) contributes to the nuclear retention of FOXO1, even when FOXO1 is phosphorylated as under non-stress conditions

  6. FoxO1 is a pivotal factor for orchestrating physiological adaptation of beta-cell mass and function to insulin (show INS Proteins) resistance, overnutrition and obesity.

  7. The effect of Sirt1 (show SIRT1 Proteins) stimulators on osteoclastogenesis was abrogated in cells lacking FoxO1, FoxO3 (show FOXO3 Proteins), and FoxO4 (show FOXO4 Proteins).

  8. Foxo1 acts as a repressor of albumin (show ALB Proteins) expression

  9. These data indicate that INS-2 reduces food intake by regulating the expression of the hypothalamic neuropeptide genes through the AKT (show AKT1 Proteins)-FoxO1 pathway downstream of insulin (show INS Proteins).

  10. FoxO1 expressed in osteoblasts as a factor affecting hematopoiesis and provide a molecular mechanism whereby the FoxO1/activated beta-catenin (show CTNNB1 Proteins) interaction results in AML (show RUNX1 Proteins).

Xenopus laevis Forkhead Box O1 (FOXO1) interaction partners

  1. FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Proteins) and catalase (show CAT Proteins) mRNA and protein levels in this organ.

Zebrafish Forkhead Box O1 (FOXO1) interaction partners

  1. These results indicate that miR (show MYLIP Proteins)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.

  2. gas6 (show GAS6 Proteins) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Proteins)-dependent inactivation of FOXO1a.

FOXO1 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

Alternative names and synonyms associated with FOXO1

  • forkhead box O1 (FOXO1)
  • forkhead box O1 (foxo1)
  • forkhead box O1 (Foxo1)
  • forkhead box O1 a (foxo1a)
  • Afxh protein
  • AI876417 protein
  • FKH1 protein
  • Fkhr protein
  • Fkhr1 protein
  • foxo1 protein
  • FoxO1A protein
  • FoxO1a.1 protein
  • xFoxO1 protein
  • zgc:153388 protein

Protein level used designations for Forkhead Box O1 Proteins (FOXO1)

forkhead box O1 , forkhead box O1A , forkhead box O1A (rhabdomyosarcoma) , forkhead box protein O1 , forkhead box protein O1-like , forkhead box protein O1A , forkhead, Drosophila, homolog of, in rhabdomyosarcoma , Forkhead box protein O1A , Forkhead in rhabdomyosarcoma , forkhead/winged helix transcription factor FOXO1a , forkhead in rhabdomyosarcoma , forkhead box O1a , forkhead protein 1 , xFoxO1 , forkhead box protein O1-A , fox family transcription factor FoxO1a.1 , foxhead box protein O1-A

100050481 Equus caballus
282234 Bos taurus
467352 Pan troglodytes
493378 Xenopus (Silurana) tropicalis
700030 Macaca mulatta
100460676 Pongo abelii
100594615 Nomascus leucogenys
2308 Homo sapiens
374231 Gallus gallus
397077 Sus scrofa
506618 Bos taurus
56458 Mus musculus
84482 Rattus norvegicus
444991 Xenopus laevis
477295 Canis lupus familiaris
101107877 Ovis aries
768121 Danio rerio
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