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Browse our FOXO1 Proteins (FOXO1)

Full name:
Forkhead Box O1 Proteins (FOXO1)
On are 9 Forkhead Box O1 (FOXO1) Proteins from 5 different suppliers available. Additionally we are shipping FOXO1 Antibodies (426) and FOXO1 Kits (50) and many more products for this protein. A total of 506 FOXO1 products are currently listed.
Afxh, AI876417, FKH1, Fkhr, Fkhr1, foxo1, FoxO1A, FoxO1a.1, xFoxO1, zgc:153388
list all proteins Gene Name GeneID UniProt
FOXO1 2308 Q12778
FOXO1 56458 Q9R1E0
Rat FOXO1 FOXO1 84482  

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FOXO1 Proteins (FOXO1) by Origin

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More Proteins for FOXO1 Interaction Partners

Cow (Bovine) Forkhead Box O1 (FOXO1) interaction partners

  1. downregulation of SIRT1 (show SIRT1 Proteins) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age

  2. FOXO (show FOXO3 Proteins) is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.

  3. Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Proteins)-1 mRNA.

  4. The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Proteins) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.

Human Forkhead Box O1 (FOXO1) interaction partners

  1. Inhibition of protooncogenic microRNA-181a may suppress proliferation and invasion and promote apoptosis of cervical cancer cells through the PTEN/Akt (show AKT1 Proteins)/FOXO1 pathway.

  2. These results indicated that curcumin may induce G2/M cell cycle arrest and apoptosis in U87 cells by increasing FoxO1 expression.

  3. we found that miR (show MLXIP Proteins)-155 promoted non-small cell lung carcinomas (NSCLC) cell proliferation through inhibition of FoxO1 and the subsequent increase of ROS (show ROS1 Proteins) generation. Our findings highlight miR (show MLXIP Proteins)-155/FoxO1/ROS (show ROS1 Proteins) axis as a novel therapeutic target for the inhibition of NSCLC growth.

  4. the data obtained in the present study provided compelling evidence that elevated expression levels of miR196a by the HCV core protein can function as an oncomicroRNA during HCVinduced cell proliferation by downregulating the expression of FOXO1, indicating a potential novel therapeutic target for HCV-related hepatocellular carcinoma .

  5. our study revealed miR (show MLXIP Proteins)-411 promoted cell proliferation of lung cancer by targeting tumor suppressor gene FOXO1 and miR (show MLXIP Proteins)-411 might be a potential target for lung cancer therapy.

  6. PTEN/Akt (show AKT1 Proteins)/FOXO1 pathway plays an important role in adriamycin-resistance of breast cancer.The expression of miR (show MLXIP Proteins)-222 is negatively correlated with FOXO1 expression in breast cancer cells.

  7. FOXO3 (show FOXO3 Proteins) is more active than FOXO1 in primitive hematopoietic stem cells; the upstream regulators other than AKT (show AKT1 Proteins), such as SIRT1 (show SIRT1 Proteins), maintain nuclear FOXO (show FOXO3 Proteins) localization and activity in hematopoietic stem cells.

  8. Study indicates FOXO1 as a critical component for progesterone signaling to promote cellular senescence and reveals a novel mechanism for transcription factor control of hormone sensitivity.

  9. Loss of Interdependent Binding by the FoxO1 and FoxA1 (show FOXA1 Proteins)/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (show INS Proteins)-sensitive Genes.

  10. FOXO1A gene polymorphic site rs4943794 is associated with an acquisition of old and senescent age and with women's longevity. FOXO3A (show FOXO3 Proteins) gene polymorphic site rs3800231 is associated with longevity in both women and men.

Pig (Porcine) Forkhead Box O1 (FOXO1) interaction partners

  1. let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Proteins) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.

  2. inhibition of FoxO1 expression level caused by miR (show MYLIP Proteins)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Proteins)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

  3. Results show that FoxO1 likely regulates MyHC I (show MYH7 Proteins) negatively and MyHC IIx and MyHC IIb (show MYH4 Proteins) positively and may play a pivotal role in the determination of muscle fiber type.

  4. Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.

  5. Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.

  6. FoxO1 and C/EBPb (show CEBPB Proteins) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Proteins)-> FoxO1-> C/EBPb (show CEBPB Proteins) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Proteins) protein complex.

  7. FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.

  8. concluded that PI 3 (show PI3 Proteins)-kinase and Akt (show AKT1 Proteins) are activated after renal ischemia/reperfusion and that Akt (show AKT1 Proteins) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (show FOXO3 Proteins), which may affect epithelial cell fate in acute renal failure.

  9. FoxO1a can regulate p27kip nuclear localization

  10. FoxO1 expression level has a negative correlation with the development of muscle fiber

Mouse (Murine) Forkhead Box O1 (FOXO1) interaction partners

  1. macrophage FoxO1 is critical to promote M1 polarization and maintain a competent T cell immune response against S. aureus infection in the liver. FoxO1 regulates macrophage M1-M2 polarization downstream of TLR2 dynamically through phosphorylation.

  2. FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation.

  3. Inhibition of NF-kappaB (show NFKB1 Proteins) pathway or knockdown of miR (show MLXIP Proteins)-705 largely prevented the decline of FoxO1-mediated antioxidant defense caused by TNF-alpha (show TNF Proteins) and ameliorated the oxidative damage in osteoporotic bone marrow-derived mesenchymal stem cells

  4. ATGL (show PNPLA2 Proteins)-dependent lipolysis plays a critical role in mediating diverse effects of FoxO (show FOXO3 Proteins) proteins in the liver, including effects on gluconeogenic, glycolytic, and lipogenic gene expression and metabolism.

  5. that FoxO1 plays a pivotal role in regulating autophagy in granulosa cells.

  6. results suggest that HMGB1 (show HMGB1 Proteins) mediates cell proliferation through a novel mechanism that involves TLR2, FoxO1 nuclear importation and PCNA (show PCNA Proteins) overexpression

  7. EGCG, insulin (show INS Proteins) and IGF-1 (show IGF1 Proteins) have roles in promoting nuclear efflux of atrophy-associated transcription factor Foxo1 in skeletal muscle fibers

  8. persistent FOXO1 activation may be responsible for insulin (show INS Proteins) resistance and impaired glucose metabolism in vitamin D signaling-deficient mice.

  9. The role of FOXO1 in podocyte epithelial-mesenchymal transition in diabetic nephropathy

  10. The data support the notion that deacetylated FoxO1 protects beta-cell function by limiting mitochondrial lipid utilization and raise the possibility that inhibition of fatty acid oxidation in beta-cells is beneficial to diabetes treatment.

Xenopus laevis Forkhead Box O1 (FOXO1) interaction partners

  1. FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Proteins) and catalase (show CAT Proteins) mRNA and protein levels in this organ.

Zebrafish Forkhead Box O1 (FOXO1) interaction partners

  1. These results indicate that miR (show MYLIP Proteins)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.

  2. gas6 (show GAS6 Proteins) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Proteins)-dependent inactivation of FOXO1a.

FOXO1 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

Alternative names and synonyms associated with FOXO1

  • forkhead box O1 (FOXO1)
  • forkhead box O1 (foxo1)
  • forkhead box O1 (Foxo1)
  • forkhead box O1 a (foxo1a)
  • Afxh protein
  • AI876417 protein
  • FKH1 protein
  • Fkhr protein
  • Fkhr1 protein
  • foxo1 protein
  • FoxO1A protein
  • FoxO1a.1 protein
  • xFoxO1 protein
  • zgc:153388 protein

Protein level used designations for Forkhead Box O1 Proteins (FOXO1)

forkhead box O1 , forkhead box O1A , forkhead box O1A (rhabdomyosarcoma) , forkhead box protein O1 , forkhead box protein O1-like , forkhead box protein O1A , forkhead, Drosophila, homolog of, in rhabdomyosarcoma , Forkhead box protein O1A , Forkhead in rhabdomyosarcoma , forkhead/winged helix transcription factor FOXO1a , forkhead in rhabdomyosarcoma , forkhead box O1a , forkhead protein 1 , xFoxO1 , forkhead box protein O1-A , fox family transcription factor FoxO1a.1 , foxhead box protein O1-A

100050481 Equus caballus
282234 Bos taurus
467352 Pan troglodytes
493378 Xenopus (Silurana) tropicalis
700030 Macaca mulatta
100460676 Pongo abelii
100594615 Nomascus leucogenys
2308 Homo sapiens
374231 Gallus gallus
397077 Sus scrofa
506618 Bos taurus
56458 Mus musculus
84482 Rattus norvegicus
444991 Xenopus laevis
477295 Canis lupus familiaris
101107877 Ovis aries
768121 Danio rerio
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