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High glucose triggers IL-1beta (show IL1B Proteins) synthesis in retinal endothelial cells. The produced IL-1beta (show IL1B Proteins) induces increased FoxO1 expression, and interacts with the IL-1 (show IL1A Proteins) receptor to activate MAPK (show MAPK1 Proteins) signaling, thereby inducing IL-1beta (show IL1B Proteins) autostimulation.
Results identified FOXO1 as a downstream effector of DKK3 that may play a role in blocking adrenocortical dedifferentiation.
Foxo1 signaling contributes to maintainance and exacerbation inflammation and insulin (show INS Proteins) resistance in polycystic ovary syndrome macrophages.
Low FOXO1 expression is associated with hepatocellular carcinoma.
presence of a new non-consensus FoxO1 binding site on the G6PC1 (show G6PC Proteins) promoter that overlaps the CRE, suggesting a mutual exclusion mechanism for FoxO1 and CREB (show CREB1 Proteins) binding at the G6PC1 (show G6PC Proteins) promoter
miR (show MLXIP Proteins)-196a-5p specifically downregulates the expression of forkhead box protein O1 (FOXO1) by targeting its 3' untranslated region (3'-UTR). FOXO1 upregulates expression of phosphotyrosine interaction domain containing 1 (PID1 (show PID1 Proteins)), thereby inhibiting GSC (show GSC Proteins) tumorigenicity and growth
we saw that GLP-1 (show GCG Proteins) induces phosphorylation of the epidermal growth factor receptor (show EGFR Proteins) and activation of Foxo1, resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1 (show GCG Proteins)-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase (show AMY Proteins) and lipase (show LIPG Proteins) levels in subjects treated with GLP-1 receptor (show GLP1R Proteins) agonists reflect adaptive growth rather than early-stage pancreatitis.
These data suggest that high doses of insulin (show INS Proteins) downregulate apoA-I (show APOA1 Proteins) gene expression in HepG2 cells through redistribution of FOXO1/LXRbeta (show NR1H2 Proteins) complex, FOXA2 (show FOXA2 Proteins), and LXRalpha (show NR1H3 Proteins) on hepatic enhancer of apoA-I (show APOA1 Proteins) gene.
FOXO1 inhibits the self-renewal capacity of gastric cancer cells through interaction with LGR5 (show LGR5 Proteins).
elevated expression of microRNA-873 facilitates Th17 differentiation by targeting forkhead box O1 (Foxo1) in the pathogenesis of systemic lupus erythematosus
These results indicate that miR (show MYLIP Proteins)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 (show GAS6 Proteins) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Proteins)-dependent inactivation of FOXO1a.
Setdb1 (show SETDB1 Proteins) regulates PTEN/AKT (show AKT1 Proteins)/FOXO1 pathway to inhibit Spermatogonial stem cells apoptosis.
These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt (show AKT1 Proteins)-FoxO1 but not p38 MAPK (show MAPK14 Proteins) or Erk1/2 MAPK (show MAPK1 Proteins) pathways.
a critical role for FOXO (show FOXO3 Proteins) transcription factors in mediating these proliferative versus apoptotic fates
L. donovani triggered AKT (show AKT1 Proteins) activation to regulate GSK-3beta/beta-catenin (show CTNNB1 Proteins)/FOXO-1 axis.
The data suggest autocrine nitric oxide/atrial natriuretic peptide (show NPPA Proteins)-induced activation of protein kinase (show CDK7 Proteins) G type Ialpha/p-AKT (show AKT1 Proteins)/p-FOXO1 promotes survival and proliferation in pancreatic beta-cells.
Myocardial ischemia is associated with downregulation and posttranslational modification of cardiac FoxO1. In a mouse model of postischemic heart failure, posttranslational modulation of FoxO1 alters heart function involving collagen and protein metabolism.
Cell fate and metabolic state are linked by transcriptional regulators, such as IRF4 (show IRF4 Proteins) and FoxO1, with dual roles in lineage and metabolic choice. Instructing some cells to utilize nutrients for anabolism and differentiation while other cells catabolically self-digest and self-renew may enable growth and repair in metazoa.
E4-ORF1 activation of PI3K in adipocytes recapitulates insulin (show INS Proteins) regulation of FoxO1 but not regulation of Glut4 (show SLC2A4 Proteins). This uncoupling of PI3K effects occurs despite E4-ORF1 activating PI3K and downstream signaling to levels achieved by insulin (show INS Proteins).
results suggest that FoxO1OB might be involved in the regulation of 1,25(OH)2D3 on glucose homeostasis and bone formation, and that FoxO1OB might act as a key modulator of the capacity of the skeleton regulating metabolic homeostasis. Our study also provides a new idea that a combination of systemic 1,25(OH)2D3 and local FoxO1 inhibitor may be a new approach to enhance implant osseointegration.
data reveal apelin (show APLN Proteins) as a novel regulator of FoxO1 in cardiac cells and provide evidence for the potential of apelin (show APLN Proteins)-13 in prevention of apoptosis and mitochondrial damage in conditions combining I/R injury and obesity.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Proteins) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR (show MYLIP Proteins)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Proteins)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I (show MYH7 Proteins) negatively and MyHC IIx and MyHC IIb (show MYH4 Proteins) positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.
Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb (show CEBPB Proteins) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Proteins)-> FoxO1-> C/EBPb (show CEBPB Proteins) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Proteins) protein complex.
FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.
concluded that PI 3 (show PI3 Proteins)-kinase and Akt (show AKT1 Proteins) are activated after renal ischemia/reperfusion and that Akt (show AKT1 Proteins) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (show FOXO3 Proteins), which may affect epithelial cell fate in acute renal failure.
FoxO1a can regulate p27kip nuclear localization
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 (show SIRT1 Proteins) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
FOXO (show FOXO3 Proteins) is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Proteins)-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Proteins) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Proteins) and catalase (show CAT Proteins) mRNA and protein levels in this organ.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like