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Browse our FOXO1 Proteins (FOXO1)

Full name:
Forkhead Box O1 Proteins (FOXO1)
On are 9 Forkhead Box O1 (FOXO1) Proteins from 5 different suppliers available. Additionally we are shipping FOXO1 Antibodies (422) and FOXO1 Kits (55) and many more products for this protein. A total of 507 FOXO1 products are currently listed.
Afxh, AI876417, FKH1, Fkhr, Fkhr1, foxo1, FoxO1A, FoxO1a.1, xFoxO1, zgc:153388
list all proteins Gene Name GeneID UniProt
FOXO1 2308 Q12778
FOXO1 56458 Q9R1E0
Rat FOXO1 FOXO1 84482  

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FOXO1 Proteins (FOXO1) by Origin

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More Proteins for FOXO1 Interaction Partners

Cow (Bovine) Forkhead Box O1 (FOXO1) interaction partners

  1. downregulation of SIRT1 (show SIRT1 Proteins) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age

  2. FOXO (show FOXO3 Proteins) is a key regulator of ROS (show ROS1 Proteins)-induced apoptosis in mammalian cells.

  3. Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (show NCAM1 Proteins)-1 mRNA.

  4. The results demonstrate pathways through which two different mediators, TNF-alpha (show TNF Proteins) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.

Human Forkhead Box O1 (FOXO1) interaction partners

  1. The studies identify a P/CAF (show KAT2B Proteins)-PAX3 (show PAX3 Proteins)-FOXO1 signalling node that promotes oncogenesis and may contribute to MyoD (show MYOD1 Proteins) dysfunction in Alveolar rhabdomyosarcoma (ARMS).

  2. Decidualization requires transcriptional upregulation of FOXO1. FOXO1 is transcribed from the same promoter in Decidual Stromal Cell as in endometrial stromal fibroblasts. Comparing the activities of FOXO1 promoters from human, mouse, manatee (Afrotheria), and opossum (marsupial) revealed that FOXO1 promoter evolved responsiveness to decidualization signals in the stem lineage of eutherians.

  3. In human fetal pancreatic progenitor cells, FoxO1 knockdown or FoxO1 inhibitor significantly upregulated Ngn3 (show NEUROG3 Proteins) and insulin (show INS Proteins) as well as the markers such as Glut2 (show SLC2A2 Proteins), Kir6.2 (show KCNJ11 Proteins), SUR1 (show ABCC8 Proteins), and VDCC, which are designated for mature beta cells. Overexpression of FoxO1 suppressed the induction and reduced expression of these beta cell markers. these results suggest that FoxO1 may act as a repressor to inhibit cell differentiation in the...

  4. Our data suggested that miR (show MLXIP Proteins)-101 suppressed HBV replication and expression partially by targeting FOXO1, providing new insights into the molecular mechanisms of miR (show MLXIP Proteins)-101 in HBV-host interactions and a promising therapeutic target for HBV replication.

  5. The age-associated higher expression of miR (show MLXIP Proteins)-96 and miR (show MLXIP Proteins)-145 might contribute to the lower expression of IGF-1R (show IGF1R Proteins) while the higher expression of miR (show MLXIP Proteins)-96, miR (show MLXIP Proteins)-145 and miR (show MLXIP Proteins)-9 might contribute to the lower expression of FOXO1 in peripheral blood mononuclear cells of aging humans.

  6. Lysophosphatidic acid/PKD-1 (show PKD1 Proteins) signaling leads to nuclear accumulation of histone deacetylase 7 (show HDAC7 Proteins), where it interacts with forkhead box protein O1 to suppress endothelial CD36 (show CD36 Proteins) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.

  7. Report shows that silencing MARCH3 (show MARCH3 Proteins) protects the endothelial barrier and upregulates OCLN (show OCLN Proteins) in MARCH3 (show MARCH3 Proteins)-depleted cells. MARCH3 (show MARCH3 Proteins) silencing results in the strengthening of cell-cell contacts and inactivates FoxO1.

  8. The diabetic state is network-wide explained by attenuation of an mTORC1-to-insulin receptor substrate-1 (IRS1 (show IRS1 Proteins)) feedback and reduced abundances of insulin receptor (show INSR Proteins), GLUT4 (show SLC2A4 Proteins), AS160 (show TBC1D4 Proteins), ribosomal protein S6 (show RPS6 Proteins), and FOXO1. The model demonstrates that attenuation of the mTORC1-to-IRS1 (show IRS1 Proteins) feedback is a major mechanism of insulin (show INS Proteins) resistance in the diabetic state.

  9. after AKT-mediated phosphorylation at serine 319, FOXO1 binds to IQGAP1, a hub for activation of the MAPK pathway, and impedes IQGAP1-dependent phosphorylation of ERK1/2 (pERK1/2).

  10. FOXO1 down-regulation and p53 overexpression characterizes a group of high-grade, pT1 stage bladder tumors with an increased probability of disease recurrence.

Pig (Porcine) Forkhead Box O1 (FOXO1) interaction partners

  1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.

  2. let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (show MAP3K1 Proteins) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.

  3. inhibition of FoxO1 expression level caused by miR (show MYLIP Proteins)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (show MYLIP Proteins)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1

  4. Results show that FoxO1 likely regulates MyHC I (show MYH7 Proteins) negatively and MyHC IIx and MyHC IIb (show MYH4 Proteins) positively and may play a pivotal role in the determination of muscle fiber type.

  5. Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (show TNFSF10 Proteins) and Fas ligand FasL (show FASL Proteins) expression during follicular atresia.

  6. Data show that IL-4 (show IL4 Proteins) induces upregulation of the junction protein claudin-5 (show CLDN5 Proteins) in endothelial cells (ECs) through activation of Jak (show JAK3 Proteins)/STAT6 (show STAT6 Proteins) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.

  7. FoxO1 and C/EBPb (show CEBPB Proteins) regulate preadipocyte adipogenesis possibly through C/EBPb (show CEBPB Proteins)-> FoxO1-> C/EBPb (show CEBPB Proteins) feedback regulatory loop and FoxO1-C/EBPb (show CEBPB Proteins) protein complex.

  8. FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.

  9. concluded that PI 3 (show PI3 Proteins)-kinase and Akt (show AKT1 Proteins) are activated after renal ischemia/reperfusion and that Akt (show AKT1 Proteins) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (show FOXO3 Proteins), which may affect epithelial cell fate in acute renal failure.

  10. FoxO1a can regulate p27kip nuclear localization

Mouse (Murine) Forkhead Box O1 (FOXO1) interaction partners

  1. Increased Forkhead box protein 1 (FoxO1) acetylation and nuclear retention was followed by progressive FoxO1 loss in beta cells that marked the onset of diabetes.

  2. Results show that microRNA miR (show MLXIP Proteins)-181c attenuated nitration stress through regulating forkhead box O1 (FoxO1) expression and affecting endothelial cell function, suggesting a target for the development of preventive or therapeutic agents against diabetes mellitus (DM).

  3. Foxo1, Foxo3a (show FOXO3 Proteins), and Foxo4 (show FOXO4 Proteins) in chondrocytes regulate endochondral bone formation.

  4. Lysophosphatidic acid/PKD-1 (show PKD1 Proteins) signaling leads to nuclear accumulation of histone deacetylase 7 (show HDAC7 Proteins), where it interacts with forkhead box protein O1 to suppress endothelial CD36 (show CD36 Proteins) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.

  5. A role of FOXO1 in the regulatory T cell differentiation process.TGF-beta induces the phosphorylation of FOXO1 in CD4 (show CD4 Proteins)+ T cells.

  6. Fucosterol inhibited adipogenesis of 3T3-L1 preadipocytes through modulation of FoxO (show FOXO3 Proteins) signalling pathway.

  7. We verified a positive correlation between the level of mir (show MLXIP Proteins)- 182 and symptom severity of experimental autoimmune encephalomyelitis (EAE) in mice and provide evidence that mir (show MLXIP Proteins)-182 inhibited Treg cells specialization through Foxo1 dependent pathway, during the pathogenesis of EAE

  8. These findings suggest that specific overexpression of renal FoxO1 decreases podocyte apoptosis, which may be explained in part by its regulation of PINK1 (show PINK1 Proteins), and that targeting FoxO1 may represent a novel therapeutic approach for diabetic nephropathy.

  9. However, Prep1 doesn't affect gluconeogenesis in the absence of insulin (show INS Proteins). Also, we observed that nuclear content of gluconeogenic transcription factor FOXO1 was greatly reduced in Prep1 knockout hepatocytes. These findings suggest that Prep1 may control hepatic insulin (show INS Proteins) sensitivity by targeting FOXO1 nuclear stability.

  10. These data suggest insulin (show INS Proteins) acts on beta-cells in an endocrine manner in the normal situation; and that in beta-cells lacking insulin (show INS Proteins) receptors, insulin (show INS Proteins) and glucose minimally activate the Akt (show AKT1 Proteins) pathway, while ERK (show EPHB2 Proteins) phosphorylation and FoxO1 nuclear export occur independently of insulin (show INS Proteins) signaling.

Xenopus laevis Forkhead Box O1 (FOXO1) interaction partners

  1. FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (show SOD1 Proteins) and catalase (show CAT Proteins) mRNA and protein levels in this organ.

Zebrafish Forkhead Box O1 (FOXO1) interaction partners

  1. These results indicate that miR (show MYLIP Proteins)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.

  2. gas6 (show GAS6 Proteins) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (show AKT1 Proteins)-dependent inactivation of FOXO1a.

FOXO1 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

Alternative names and synonyms associated with FOXO1

  • forkhead box O1 (FOXO1)
  • forkhead box O1 (foxo1)
  • forkhead box O1 (Foxo1)
  • forkhead box O1 a (foxo1a)
  • Afxh protein
  • AI876417 protein
  • FKH1 protein
  • Fkhr protein
  • Fkhr1 protein
  • foxo1 protein
  • FoxO1A protein
  • FoxO1a.1 protein
  • xFoxO1 protein
  • zgc:153388 protein

Protein level used designations for Forkhead Box O1 Proteins (FOXO1)

forkhead box O1 , forkhead box O1A , forkhead box O1A (rhabdomyosarcoma) , forkhead box protein O1 , forkhead box protein O1-like , forkhead box protein O1A , forkhead, Drosophila, homolog of, in rhabdomyosarcoma , Forkhead box protein O1A , Forkhead in rhabdomyosarcoma , forkhead/winged helix transcription factor FOXO1a , forkhead in rhabdomyosarcoma , forkhead box O1a , forkhead protein 1 , xFoxO1 , forkhead box protein O1-A , fox family transcription factor FoxO1a.1 , foxhead box protein O1-A

100050481 Equus caballus
282234 Bos taurus
467352 Pan troglodytes
493378 Xenopus (Silurana) tropicalis
700030 Macaca mulatta
100460676 Pongo abelii
100594615 Nomascus leucogenys
2308 Homo sapiens
374231 Gallus gallus
397077 Sus scrofa
506618 Bos taurus
56458 Mus musculus
84482 Rattus norvegicus
444991 Xenopus laevis
477295 Canis lupus familiaris
101107877 Ovis aries
768121 Danio rerio
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