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Browse our GRIA4 Proteins (GRIA4)

Full name:
Glutamate Receptor, Ionotrophic, AMPA 4 Proteins (GRIA4)
On are 7 Glutamate Receptor, Ionotrophic, AMPA 4 (GRIA4) Proteins from 2 different suppliers available. Additionally we are shipping GRIA4 Antibodies (101) and GRIA4 Kits (26) and many more products for this protein. A total of 141 GRIA4 products are currently listed.
DKFZp459P0616, GluA4, Glur-4, GluR-D, Glur4, GLUR4/D, GLUR4C, GluR4d, Gluralpha4, GLURD, spkw1
list all proteins Gene Name GeneID UniProt
GRIA4 2893 P48058
Rat GRIA4 GRIA4 29629 P19493
GRIA4 14802 Q9Z2W8

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GRIA4 Proteins (GRIA4) by Origin

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Human Glutamate Receptor, Ionotrophic, AMPA 4 (GRIA4) interaction partners

  1. A transient positive feedback mechanism between AMPAR and stargazin has implications for information processing in the brain, because it should allow activity-dependent facilitation of excitatory synaptic transmission through a postsynaptic mechanism.

  2. This study demonstrated that the GRIA4 protein was altered in auditory cortex patient with schizophreia.

  3. Interaction with the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR4.

  4. the levels were comparable for complexes containing GluR2 (show GRIA2 Proteins), GluR3 (show GRIA3 Proteins) and GluR4 as well as 5-HT1A (show HTR1A Proteins). Moreover, the levels of complexes containing muscarinic AChR M1, NR1 (show GRIN1 Proteins) and GluR1 (show GRIA1 Proteins) were significantly increased in male patients with AD.

  5. Statistical analysis showed no association between migraine and the GRIA2 (show GRIA2 Proteins) and GRIA4 polymorphisms investigated.

  6. The N-terminal domain modulates alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA (show GRIA3 Proteins)) receptor desensitization.

  7. The data potentially suggest a lack of epistatic interaction between GRIA2 (show GRIA2 Proteins) and GRIA4 variants regarding clinical outcomes in patients with major depressive disorder.

  8. Did not observed any significant association between GRIA4 polymorphisms and clinical improvement in patients with Major depressive disorder.

  9. SNPs within GRIA4 may not be associated with the development and treatment outcomes in BD

  10. No significant association GRIA4 polymorphisms was found with the diagnosis of schizophrenia.

Mouse (Murine) Glutamate Receptor, Ionotrophic, AMPA 4 (GRIA4) interaction partners

  1. Data indicate that the AMPA (show GRIA3 Proteins) receptor subunits abundance is hippocampus, GluA2 (show GRIA2 Proteins) > GluA1 (show GRIA1 Proteins) > GluA3 (show GRIA3 Proteins) >> GluA4; cortex, GluA2 (show GRIA2 Proteins) > GluA3 (show GRIA3 Proteins) >/= GluA1 (show GRIA1 Proteins) >> GluA4; and cerebellum, GluA2 (show GRIA2 Proteins) > GluA3 (show GRIA3 Proteins) >/= GluA1 (show GRIA1 Proteins) > GluA4.

  2. Here we identify a novel modifier - called "pecanex-like 2", or Pcnxl2 for short - that reduces the severity of spike-wave dischargesin the C3H substrain in which the Gria4 mutation originally arose

  3. GluA4 expression is sufficient to alter the signaling mechanisms of synaptic plasticity and can fully explain the switch in the kinase dependency of long-term potentiation from PKA to Ca2+/calmodulin-dependent protein kinase II during synapse maturation.

  4. Postsynaptic density fractions from spinal cord dorsal horns showed an increase in GluA4 expression after morphine discontinuation.

  5. The GluA4 subunit of the AMPA (show GRIA3 Proteins) receptor in the hippocampus (GluA4(HC-/-) mice) was ablated, thereby selectively reducing AMPA (show GRIA3 Proteins) receptor-mediated currents onto a subgroup of hippocampal interneurons expressing GluA4.

  6. study found the majority of cerebellar GluA1 (show GRIA1 Proteins)/A4-type AMPARs are expressed in Bergmann glial (BG) cells; BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life

  7. Western blotting of surface cross-linked cerebellar samples shows a significantly lower surface level of the GluR4 AMPA receptor subunit in Ppt1-deficient mice.

  8. This study suggested new moddel of absence epilepsy with gria4 deificent mice.

  9. GluR4-deficient mice exhibit schizophrenia-related phenotypes: drastically impaired prepulse inhibition (PPI) of the acoustic startle response and enhanced sensitivity to the locomotor stimulatory effects of a NMDA receptor antagonist, MK-801.

  10. The highest level of GluR4 mRNA was detected in rats at PND7.

GRIA4 Protein Profile

Protein Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA\; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.

Alternative names and synonyms associated with GRIA4

  • glutamate receptor, ionotropic, AMPA 4 (GRIA4)
  • glutamate receptor, ionotropic, AMPA 4 (gria4)
  • glutamate receptor, ionotrophic, AMPA 4 (GRIA4)
  • glutamate receptor, ionotropic, AMPA 4 (Gria4)
  • glutamate receptor, ionotropic, AMPA4 (alpha 4) (Gria4)
  • DKFZp459P0616 protein
  • GluA4 protein
  • Glur-4 protein
  • GluR-D protein
  • Glur4 protein
  • GLUR4/D protein
  • GLUR4C protein
  • GluR4d protein
  • Gluralpha4 protein
  • GLURD protein
  • spkw1 protein

Protein level used designations for GRIA4

glutamate receptor, ionotrophic, AMPA 4 , AMPA receptor GluR4/D , glutamate receptor subunit GluR4 , glutamate receptor 4 , AMPA-selective glutamate receptor 4 , gluR-4 , gluR-D , glutamate receptor, ionotropic, AMPA4 (alpha 4) , glutamate receptor channel alpha 4 , glutamate receptor ionotropic, AMPA 4 , spike wave 1

396137 Gallus gallus
100125052 Xenopus (Silurana) tropicalis
466768 Pan troglodytes
489427 Canis lupus familiaris
100173919 Pongo abelii
529904 Bos taurus
2893 Homo sapiens
29629 Rattus norvegicus
14802 Mus musculus
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