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HK2 functions as a novel oncogene (show RAB1A ELISA Kits) in lung cancer and may be a potential therapeutic target for lung cancer.
Cells with HKII knockdown showed no changes in 3BP sensitivity, suggesting the effects of 3BP are independent of HKII expression.
Suggest HK2 as an independent prognostic indicator of radiation resistance in cervical squamous carcinoma.
High exokinase 2 expression is associated with neuroblastoma (show ARHGEF16 ELISA Kits) metastasis.
The degree of plaque disruption and expression of TF and HK-II appear to be important vascular factors for AMI (show CFD ELISA Kits) onset, and polarized macrophages make a distinct contribution to thrombogenicity and glucose metabolism.
The overexpression of Hk2 (and Pkm2) sustains high levels of glycolysis during embryonic stem cell differentiation.
In the present study it was determined whether three key enzymes for glycolysis, glutaminolysis and de novo synthesis of FAs (show FAS ELISA Kits), hexokinase-2, glutaminase (show GLS ELISA Kits) and fatty acid synthase (show FASN ELISA Kits)
HK1 (show KCNA4 ELISA Kits) and HK2 expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 (show HK3 ELISA Kits) expression level was significantly increased in 60% of samples.
In conclusion, our findings suggested that miR (show MLXIP ELISA Kits)-4458 inhibited the progression of colon cancer cells by inhibition of glycolysis and lactate production via directly targeting HK2 mRNA.
Hexokinase 2 controls cellular stress response through localization of hnRNP A1 (show HNRNPA1 ELISA Kits).
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (show SIRT3 ELISA Kits) KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten/p53 (show TP53 ELISA Kits) mutations. HK2 is required for Pten-/p53 (show TP53 ELISA Kits)-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (show SLC2A1 ELISA Kits) and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS (show ROS1 ELISA Kits) accumulation via increased pentose phosphate pathway flux.
phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt (show AKT1 ELISA Kits).
Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury.
HKII mitochondrial binding is also important for the hypertrophic effects, as HKII dissociation from the mitochondria resulted in de novo hypertrophy.
We identified miR (show MLXIP ELISA Kits)-143 as an essential regulator of cancer glycolysis via targeting HK2.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, HK II
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, likely hexokinase II