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Browse our Hexokinase 2 Proteins (HK2)

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Hexokinase 2 Proteins (HK2)
On are 24 Hexokinase 2 (HK2) Proteins from 11 different suppliers available. Additionally we are shipping Hexokinase 2 Antibodies (170) and Hexokinase 2 Kits (16) and many more products for this protein. A total of 217 Hexokinase 2 products are currently listed.
AI642394, ARABIDOPSIS THALIANA HEXOKINASE 2, ATHXK2, F6F22.11, F6F22_11, fi09d05, fi17h06, hexokinase-2, hexokinase 2, HK2, HKII, HXK2, wu:fi09d05, wu:fi17h06, wu:fi31b04, zgc:55926
list all proteins Gene Name GeneID UniProt
HK2 3099 P52789
HK2 15277 O08528
Rat HK2 HK2 25059 P27881

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Hexokinase 2 Proteins (HK2) by Origin

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Top referenced Hexokinase 2 Proteins

  1. Human Hexokinase 2 Protein expressed in Escherichia coli (E. coli) - ABIN668036 : Furuta, Nishi, Le Beau, Fernald, Yano, Bell: Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. in Genomics 1997 (PubMed)
    Show all 2 references for ABIN668036

  2. Human Hexokinase 2 Protein expressed in Wheat germ - ABIN2752811 : Richter, Richter, Mehta, Gribble, Sutherland-Smith, Stowell, Print, Ronimus, Wilson: Expression and role in glycolysis of human ADP-dependent glucokinase. in Molecular and cellular biochemistry 2012 (PubMed)

More Proteins for Hexokinase 2 Interaction Partners

Human Hexokinase 2 (HK2) interaction partners

  1. miR (show MLXIP Proteins)-181b directly inhibits the expression level of hexokinase 2 (HK2), a key enzyme that catalyzes the first step of glycolysis, through targeting its 3'-untranslated region.

  2. The N-terminal end of HKII has a mitochondrial-binding site and a VDAC bindig site.

  3. HK2 functions as a novel oncogene (show RAB1A Proteins) in lung cancer and may be a potential therapeutic target for lung cancer.

  4. Cells with HKII knockdown showed no changes in 3BP sensitivity, suggesting the effects of 3BP are independent of HKII expression.

  5. Suggest HK2 as an independent prognostic indicator of radiation resistance in cervical squamous carcinoma.

  6. High exokinase 2 expression is associated with neuroblastoma (show ARHGEF16 Proteins) metastasis.

  7. The degree of plaque disruption and expression of TF and HK-II appear to be important vascular factors for AMI (show CFD Proteins) onset, and polarized macrophages make a distinct contribution to thrombogenicity and glucose metabolism.

  8. The overexpression of Hk2 (and Pkm2) sustains high levels of glycolysis during embryonic stem cell differentiation.

  9. In the present study it was determined whether three key enzymes for glycolysis, glutaminolysis and de novo synthesis of FAs (show FAS Proteins), hexokinase-2, glutaminase (show GLS Proteins) and fatty acid synthase (show FASN Proteins)

  10. HK1 (show KCNA4 Proteins) and HK2 expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 (show HK3 Proteins) expression level was significantly increased in 60% of samples.

Mouse (Murine) Hexokinase 2 (HK2) interaction partners

  1. Hexokinase expression is highly enriched in neurons compared to astrocytes.

  2. Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (show SIRT3 Proteins) KO mice.

  3. HK2 is upregulated in prostate cancer cells harboring Pten/p53 (show TP53 Proteins) mutations. HK2 is required for Pten-/p53 (show TP53 Proteins)-deficiency-driven prostate tumor growth in vivo.

  4. A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (show SLC2A1 Proteins) and HK2 were observed after radiation treatment.

  5. Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.

  6. Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS (show ROS1 Proteins) accumulation via increased pentose phosphate pathway flux.

  7. phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt (show AKT1 Proteins).

  8. Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury.

  9. HKII mitochondrial binding is also important for the hypertrophic effects, as HKII dissociation from the mitochondria resulted in de novo hypertrophy.

  10. We identified miR (show MLXIP Proteins)-143 as an essential regulator of cancer glycolysis via targeting HK2.

Horse (Equine) Hexokinase 2 (HK2) interaction partners

  1. The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.

Hexokinase 2 (HK2) Protein Profile

Protein Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Alternative names and synonyms associated with Hexokinase 2 (HK2)

  • hexokinase 2 (HK2)
  • hexokinase 2 (hk2)
  • hexokinase 2 (Hk2)
  • hexokinase 2 (HXK2)
  • hexokinase-2-like (LOC100856448)
  • similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose; similar to S. cerevisiae HXK2 (YGL253W) (HXK2)
  • AI642394 protein
  • ATHXK2 protein
  • F6F22.11 protein
  • F6F22_11 protein
  • fi09d05 protein
  • fi17h06 protein
  • hexokinase-2 protein
  • hexokinase 2 protein
  • HK2 protein
  • HKII protein
  • HXK2 protein
  • wu:fi09d05 protein
  • wu:fi17h06 protein
  • wu:fi31b04 protein
  • zgc:55926 protein

Protein level used designations for Hexokinase 2 Proteins (HK2)

hexokinase 2 , hexokinase-2-like , HK II , hexokinase type II , hexokinase-2 , hexokinase-2, muscle , muscle form hexokinase , hexokinase II , DrHXK2 , likely hexokinase II

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3641015 Candida albicans SC5314
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