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Human Hexokinase 2 Primary Antibody for SDS - ABIN668036
Furuta, Nishi, Le Beau, Fernald, Yano, Bell: Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. in Genomics 1997
Show all 2 references for ABIN668036
Human Hexokinase 2 Primary Antibody for AP, AA - ABIN2752811
Richter, Richter, Mehta, Gribble, Sutherland-Smith, Stowell, Print, Ronimus, Wilson: Expression and role in glycolysis of human ADP-dependent glucokinase. in Molecular and cellular biochemistry 2012
Results from the simulations show that HK2 binding restricts the movement of the VDAC1 (show VDAC1 Proteins) N-terminal helix. As a result, VDAC1 (show VDAC1 Proteins) is kept in the open state most of the time and probably allows a constant supply of ATP to HK2 for glycolysis.
These results suggest that HK2 plays important roles in the glycolytic, proliferation and migration properties of colorectal carcinoma
High HK2 expression is associated with prostate cancer.
We demonstrated that the expression levels of glycolysis-related proteins glucose transporter 1 (show SLC2A1 Proteins), hexokinase II, carbonic anhydrase IX (show CA9 Proteins), and monocarbonylate transporter 4 differ between thyroid cancer subtypes and are correlated with poorer prognosis
miR (show MLXIP Proteins)-181b directly inhibits the expression level of hexokinase 2 (HK2), a key enzyme that catalyzes the first step of glycolysis, through targeting its 3'-untranslated region.
The N-terminal end of HKII has a mitochondrial-binding site and a VDAC bindig site.
HK2 functions as a novel oncogene (show RAB1A Proteins) in lung cancer and may be a potential therapeutic target for lung cancer.
Cells with HKII knockdown showed no changes in 3BP sensitivity, suggesting the effects of 3BP are independent of HKII expression.
Suggest HK2 as an independent prognostic indicator of radiation resistance in cervical squamous carcinoma.
High exokinase 2 expression is associated with neuroblastoma (show ARHGEF16 Proteins) metastasis.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (show SIRT3 Proteins) KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten/p53 (show TP53 Proteins) mutations. HK2 is required for Pten-/p53 (show TP53 Proteins)-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (show SLC2A1 Proteins) and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS (show ROS1 Proteins) accumulation via increased pentose phosphate pathway flux.
phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt (show AKT1 Proteins).
Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury.
HKII mitochondrial binding is also important for the hypertrophic effects, as HKII dissociation from the mitochondria resulted in de novo hypertrophy.
We identified miR (show MLXIP Proteins)-143 as an essential regulator of cancer glycolysis via targeting HK2.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, HK II
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, likely hexokinase II