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SIRT6 (show SIRT6 Proteins) over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 promoter chromatin structure makes it receptive to interaction with MZF1 (show ZFP42 Proteins)/SIRT6 (show SIRT6 Proteins) complex, thereby favouring a regulatory state conducive to diminished transcription
findings suggested that PVT1 contributes to osteosarcoma (OS) cell glucose metabolism, cell proliferation, and motility through the miR (show MLXIP Proteins)-497/HK2 pathway, and revealed a novel relation between lncRNA and the alteration of glycolysis in OS cells
High HKII expression is associated with metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma.
The EML4-ALK-mediated upregulation of HIF1alpha, HK2 and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxyglucose-positron emission tomography imaging of xenografts grown from EML4-ALK-positive NSCLC cells.
relevant number of patients with FDG (show SMUG1 Proteins)-PET false-negative multiple myeloma and a strong association between hexokinase-2 expression and this negativity: a finding which may also be relevant for clinical imaging of other hematological cancers.
MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.
High HK2 expression is associated with prostate cancer.
Metformin downregulated both endogenous and exogenous UCA1 expression, leading to the inhibition of mammalian target of rapamycin (show FRAP1 Proteins)-signal transducer and activator of transcription 3 (show STAT3 Proteins)-hexokinase 2 signaling pathway. Our study provided the first evidence that metformin inhibited proliferation and glycolysis in cancer cells through regulation of long non-coding RNA UCA1
AKT (show AKT1 Proteins) inhibition blocks miR (show MLXIP Proteins)-124 silencing-induced AKT1 (show AKT1 Proteins)/2, glucose transporter 1 (show SLC2A1 Proteins), hexokinase II activation, cell proliferation, and glycolytic or energy metabolism changes. In summary, this study demonstrated that miR (show MLXIP Proteins)-124 is able to inhibit proliferation, glycolysis, and energy metabolism, potentially by targeting AKT1 (show AKT1 Proteins)/2-glucose transporter 1 (show SLC2A1 Proteins)/hexokinase II in non-small cell lung cancer cells.
Results from the simulations show that HK2 binding restricts the movement of the VDAC1 (show VDAC1 Proteins) N-terminal helix. As a result, VDAC1 (show VDAC1 Proteins) is kept in the open state most of the time and probably allows a constant supply of ATP to HK2 for glycolysis.
changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (show SIRT3 Proteins) KO mice.
HK2 is upregulated in prostate cancer cells harboring Pten/p53 (show TP53 Proteins) mutations. HK2 is required for Pten-/p53 (show TP53 Proteins)-deficiency-driven prostate tumor growth in vivo.
A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (show SLC2A1 Proteins) and HK2 were observed after radiation treatment.
Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.
Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS (show ROS1 Proteins) accumulation via increased pentose phosphate pathway flux.
phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt (show AKT1 Proteins).
Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury.
HKII mitochondrial binding is also important for the hypertrophic effects, as HKII dissociation from the mitochondria resulted in de novo hypertrophy.
The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
, HK II
, hexokinase type II
, hexokinase-2, muscle
, muscle form hexokinase
, hexokinase II
, likely hexokinase II