Browse our Hexokinase 2 Proteins (HK2)

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Hexokinase 2 Proteins (HK2)
On are 23 Hexokinase 2 (HK2) Proteins from 10 different suppliers available. Additionally we are shipping Hexokinase 2 Antibodies (176) and Hexokinase 2 Kits (17) and many more products for this protein. A total of 223 Hexokinase 2 products are currently listed.
AI642394, ARABIDOPSIS THALIANA HEXOKINASE 2, ATHXK2, F6F22.11, F6F22_11, fi09d05, fi17h06, hexokinase-2, hexokinase 2, HK2, HKII, HXK2, wu:fi09d05, wu:fi17h06, wu:fi31b04, zgc:55926
list all proteins Gene Name GeneID UniProt
HK2 3099 P52789
HK2 15277 O08528
Rat HK2 HK2 25059 P27881

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Hexokinase 2 Proteins (HK2) by Origin

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Top referenced Hexokinase 2 Proteins

  1. Human Hexokinase 2 Protein expressed in Escherichia coli (E. coli) - ABIN668036 : Furuta, Nishi, Le Beau, Fernald, Yano, Bell: Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. in Genomics 1997 (PubMed)
    Show all 2 references for 668036

  2. Human Hexokinase 2 Protein expressed in Wheat germ - ABIN2752811 : Richter, Richter, Mehta, Gribble, Sutherland-Smith, Stowell, Print, Ronimus, Wilson: Expression and role in glycolysis of human ADP-dependent glucokinase. in Molecular and cellular biochemistry 2012 (PubMed)

More Proteins for Hexokinase 2 Interaction Partners

Human Hexokinase 2 (HK2) interaction partners

  1. MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells.

  2. High HK2 expression is associated with prostate cancer.

  3. Metformin downregulated both endogenous and exogenous UCA1 expression, leading to the inhibition of mammalian target of rapamycin (show FRAP1 Proteins)-signal transducer and activator of transcription 3 (show STAT3 Proteins)-hexokinase 2 signaling pathway. Our study provided the first evidence that metformin inhibited proliferation and glycolysis in cancer cells through regulation of long non-coding RNA UCA1

  4. AKT (show AKT1 Proteins) inhibition blocks miR (show MLXIP Proteins)-124 silencing-induced AKT1 (show AKT1 Proteins)/2, glucose transporter 1 (show SLC2A1 Proteins), hexokinase II activation, cell proliferation, and glycolytic or energy metabolism changes. In summary, this study demonstrated that miR (show MLXIP Proteins)-124 is able to inhibit proliferation, glycolysis, and energy metabolism, potentially by targeting AKT1 (show AKT1 Proteins)/2-glucose transporter 1 (show SLC2A1 Proteins)/hexokinase II in non-small cell lung cancer cells.

  5. Results from the simulations show that HK2 binding restricts the movement of the VDAC1 (show VDAC1 Proteins) N-terminal helix. As a result, VDAC1 (show VDAC1 Proteins) is kept in the open state most of the time and probably allows a constant supply of ATP to HK2 for glycolysis.

  6. These results suggest that HK2 plays important roles in the glycolytic, proliferation and migration properties of colorectal carcinoma

  7. High HK2 expression is associated with prostate cancer.

  8. We demonstrated that the expression levels of glycolysis-related proteins glucose transporter 1 (show SLC2A1 Proteins), hexokinase II, carbonic anhydrase IX (show CA9 Proteins), and monocarbonylate transporter 4 differ between thyroid cancer subtypes and are correlated with poorer prognosis

  9. miR (show MLXIP Proteins)-181b directly inhibits the expression level of hexokinase 2 (HK2), a key enzyme that catalyzes the first step of glycolysis, through targeting its 3'-untranslated region.

  10. The N-terminal end of HKII has a mitochondrial-binding site and a VDAC bindig site.

Mouse (Murine) Hexokinase 2 (HK2) interaction partners

  1. Hexokinase expression is highly enriched in neurons compared to astrocytes.

  2. Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 (show SIRT3 Proteins) KO mice.

  3. HK2 is upregulated in prostate cancer cells harboring Pten/p53 (show TP53 Proteins) mutations. HK2 is required for Pten-/p53 (show TP53 Proteins)-deficiency-driven prostate tumor growth in vivo.

  4. A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 (show SLC2A1 Proteins) and HK2 were observed after radiation treatment.

  5. Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate.

  6. Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS (show ROS1 Proteins) accumulation via increased pentose phosphate pathway flux.

  7. phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt (show AKT1 Proteins).

  8. Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury.

  9. HKII mitochondrial binding is also important for the hypertrophic effects, as HKII dissociation from the mitochondria resulted in de novo hypertrophy.

  10. We identified miR (show MLXIP Proteins)-143 as an essential regulator of cancer glycolysis via targeting HK2.

Horse (Equine) Hexokinase 2 (HK2) interaction partners

  1. The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.

Hexokinase 2 (HK2) Protein Profile

Protein Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.

Alternative names and synonyms associated with Hexokinase 2 (HK2)

  • hexokinase 2 (HK2)
  • hexokinase 2 (hk2)
  • hexokinase 2 (Hk2)
  • hexokinase 2 (HXK2)
  • hexokinase-2-like (LOC100856448)
  • similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose; similar to S. cerevisiae HXK2 (YGL253W) (HXK2)
  • AI642394 protein
  • ATHXK2 protein
  • F6F22.11 protein
  • F6F22_11 protein
  • fi09d05 protein
  • fi17h06 protein
  • hexokinase-2 protein
  • hexokinase 2 protein
  • HK2 protein
  • HKII protein
  • HXK2 protein
  • wu:fi09d05 protein
  • wu:fi17h06 protein
  • wu:fi31b04 protein
  • zgc:55926 protein

Protein level used designations for Hexokinase 2 Proteins (HK2)

hexokinase 2 , hexokinase-2-like , HK II , hexokinase type II , hexokinase-2 , hexokinase-2, muscle , muscle form hexokinase , hexokinase II , DrHXK2 , likely hexokinase II

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