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Browse our PDK1 Proteins (PDK1)

Full name:
Pyruvate Dehydrogenase Kinase, Isozyme 1 Proteins (PDK1)
On are 8 Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) Proteins from 4 different suppliers available. Additionally we are shipping PDK1 Antibodies (16) and PDK1 Kits (7) and many more products for this protein. A total of 32 PDK1 products are currently listed.
B830012B01, D530020C15Rik, si:zfos-979f1.3
list all proteins Gene Name GeneID UniProt
PDK1 228026 Q8BFP9
PDK1 5163 Q15118
Rat PDK1 PDK1 116551  

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PDK1 Proteins (PDK1) by Origin

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Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. PTEN is required for stabilization of planar cell packing in the neural plate and for the formation of stable apical-basal microtubule arrays, while PDPK1 (show PDPK1 Proteins) is required for stabilization of apical junctions during epithelial morphogenesis.

  2. results thus reveal an essential role for the PDK1 (show PDPK1 Proteins)-Akt (show AKT1 Proteins) pathway in the regulation of a key step of neuronal migration.

  3. PDK1 (show PDPK1 Proteins) plays a pivotal role in regulating cardiac function and tumor metastasis by interfering with microenvironment.

  4. Our data suggest that two arms of the glucose metabolism synergistically regulate the differential activation of macrophages. Our findings also highlight the central role of PDK1 (show PDPK1 Proteins) in this event via controlling glycolysis and glucose oxidation.

  5. PDHK1 is expressed in Th17 cells, but not Th1 (show HAND1 Proteins) cells, and at low levels in Tregs, and inhibition or knockdown of PDHK1 selectively suppressed Th17 cells and increased Tregs.

  6. The tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC (show PDC Proteins) binding.

  7. Pdk1 (show PDPK1 Proteins) enzyme is critical in conserving mitochondrial function by diverting metabolic intermediates to glycolysis

Human Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. PDK1 is frequently upregulated in primary nasopharyngeal carcinoma and may serve as a prognostic marker.

  2. A new function for PDK1 in metabolic reprogramming, which could be used to indicate the prognosis of Non small cell lung cancer and provide targeted therapeutic strategy for clinical treatment.

  3. Our results demonstrated that down-regulation of SDHB (show SDHB Proteins) and up-regulation of PDK1 may be novel biomarkers for predicting advanced tumor progression and unfavorable prognosis in recurrent nasopharyngeal carcinoma patients

  4. n the conditon of miR (show MLXIP Proteins)- 128b over-expression, we also observed spontaneous inactivation of the Akt (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) signalling, implying PDK1 was a potential regulator of this pathway. In conclusion, our study shed some novel light on miR (show MLXIP Proteins)-128b-PDK1/Akt (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) axis onGastric cancer (GC) progression

  5. Dichloroacetate, an Iihibitor of PDK1, can reverse the mitochondrial suppression of renal cell carcinoma (show MOK Proteins) and decrease HIF transcriptional activity, decreasing tumor growth and angiogenesis.

  6. Tergeting PDK1 with dichloroacetophenone inhibited acute myeloid leukemia (show BCL11A Proteins) cell growth via multiple signaling pathways.

  7. PDK1 was specifically required for metabolic adaptation to nutrient limitation and hypoxia.

  8. High expression of PDK1 is associated with Colon Cancer.

  9. both PDK 1 and 2 isoforms are overexpressed in cutaneous melanoma compared to nevi, this expression being associated with the expression of the mTOR (show FRAP1 Proteins) pathway effectors and independent of the BRAF (show BRAF Proteins) mutational status

  10. Lin28A (show LIN28A Proteins) and Lin28B (show LIN28B Proteins) enhance, whereas let-7 suppresses, aerobic glycolysis via targeting pyruvate dehydrogenase kinase 1, or PDK1.

Pig (Porcine) Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. Dephosphorylation of PDK1 may be a molecular switch for enhancement of protein tyrosine phosphorylation and flagellar hyperactivation in boar spermatozoa.

PDK1 Protein Profile

Protein Summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.

Alternative names and synonyms associated with PDK1

  • pyruvate dehydrogenase kinase, isozyme 1 (PDK1)
  • pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1)
  • pyruvate dehydrogenase kinase, isozyme 1 (Pdk1)
  • pyruvate dehydrogenase kinase, isozyme 1 (pdk1)
  • B830012B01 protein
  • D530020C15Rik protein
  • si:zfos-979f1.3 protein

Protein level used designations for PDK1

pyruvate dehydrogenase kinase, isoenzyme 1 , pyruvate dehydrogenase kinase, isozyme 1 , pyruvate dehydrogenase [lipoamide] kinase isozyme 1, mitochondrial-like , PDH kinase 1 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial , mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1 , PDK p48 , pyruvate dehydrogenase kinase 1

100218846 Taeniopygia guttata
100402844 Callithrix jacchus
100601990 Nomascus leucogenys
228026 Mus musculus
5163 Homo sapiens
116551 Rattus norvegicus
555840 Danio rerio
425972 Gallus gallus
100286871 Sus scrofa
528655 Bos taurus
476828 Canis lupus familiaris
432080 Xenopus laevis
100064091 Equus caballus
100351323 Oryctolagus cuniculus
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