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Browse our PDK1 Proteins (PDK1)

Full name:
Pyruvate Dehydrogenase Kinase, Isozyme 1 Proteins (PDK1)
On are 19 Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) Proteins from 12 different suppliers available. Additionally we are shipping PDK1 Antibodies (141) and PDK1 Kits (6) and many more products for this protein. A total of 175 PDK1 products are currently listed.
B830012B01, D530020C15Rik, si:zfos-979f1.3
list all proteins Gene Name GeneID UniProt
PDK1 228026 Q8BFP9
PDK1 5163 Q15118
Rat PDK1 PDK1 116551  

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PDK1 Proteins (PDK1) by Origin

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Top referenced PDK1 Proteins

  1. Human PDK1 Protein expressed in Escherichia coli (E. coli) - ABIN666881 : Xie, Yuan, Yin, Zeng, Bai, Glazer: 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases. in BMC cancer 2006 (PubMed)
    Show all 2 references for ABIN666881

  2. Human PDK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005169 : Kato, Li, Chuang, Chuang: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. in Structure (London, England : 1993) 2007 (PubMed)
    Show all 2 references for ABIN2005169

More Proteins for PDK1 Interaction Partners

Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. PDK1 (show PDPK1 Proteins) plays a pivotal role in regulating cardiac function and tumor metastasis by interfering with microenvironment.

  2. Taken together, our results suggest that LPS (show TLR4 Proteins) induces PDK4 (show PDK4 Proteins) expression and alters glucose metabolism via the JNK (show MAPK8 Proteins) pathway.

  3. hypothesize that PDK1 (show PDPK1 Proteins) plays a significant role in the progression and growth of vascular tumors and targeting PDK1 (show PDPK1 Proteins) may thus be considered in their treatment

  4. PDK1 (show PDPK1 Proteins) ablation promotes epidermal and T-cell mediated dysfunction leading to dermatitis.

  5. T34 phosphorylation by PDK1 (show PDPK1 Proteins) promotes the membrane dissociation of activated Akt (show AKT1 Proteins) for its downstream action through attenuating membrane binding affinity.

  6. These results indicate that PDK1 (show PDPK1 Proteins) participates in the dysregulation of electrophysiological basis by regulating the PDK1 (show PDPK1 Proteins)-Foxo1 (show FOXO1 Proteins) pathway

  7. Our data suggest that two arms of the glucose metabolism synergistically regulate the differential activation of macrophages. Our findings also highlight the central role of PDK1 (show PDPK1 Proteins) in this event via controlling glycolysis and glucose oxidation.

  8. PDHK1 is expressed in Th17 cells, but not Th1 (show HAND1 Proteins) cells, and at low levels in Tregs, and inhibition or knockdown of PDHK1 selectively suppressed Th17 cells and increased Tregs.

  9. Direct genetic evidence for the importance of PDK1 (show PDPK1 Proteins), in part through FOXO3a (show FOXO3 Proteins)-dependent pathway, in melanoma development and progression.

  10. Data show that insulin (show INS Proteins) stimulates GLUT4 (show SLC2A4 Proteins) translocation to the cell surface and iglucose uptake in an Akt1 (show AKT1 Proteins)/2-dependent manner; PI3K phosphorylates Thr308 and Ser473 for Akt1 (show AKT1 Proteins) and Ser474 alone for Akt2 (show AKT2 Proteins); and PDK1 (show PDPK1 Proteins) phosphorylates Thr308 for Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins).

Human Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. PDK1 was specifically required for metabolic adaptation to nutrient limitation and hypoxia.

  2. High expression of PDK1 is associated with Colon Cancer.

  3. both PDK 1 and 2 isoforms are overexpressed in cutaneous melanoma compared to nevi, this expression being associated with the expression of the mTOR (show FRAP1 Proteins) pathway effectors and independent of the BRAF (show BRAF Proteins) mutational status

  4. Lin28A (show LIN28A Proteins) and Lin28B (show LIN28B Proteins) enhance, whereas let-7 suppresses, aerobic glycolysis via targeting pyruvate dehydrogenase kinase 1, or PDK1.

  5. Follow-up replication analyses in up to an additional 21,345 participants identified three new fasting plasma glucose loci reaching genome-wide significance in or near PDK1-RAPGEF4 (show RAPGEF4 Proteins), KANK1, and IGF1R (show IGF1R Proteins).

  6. NOR1 (show NR4A3 Proteins) expression causes apoptosis of tumor cells in hypoxia by altering the expression of PDK1 expression and mitochondrial Bax (show BAX Proteins)-Bcl2 (show BCL2 Proteins) balance thus suppress tumor cell adaptation to hypoxia

  7. Accordingly, elevated levels of PDK1, PDK3, and PKM2 and reduced PK activity could be observed in iPSCs and human embryonic stem cells in the undifferentiated state

  8. High expression of pyruvate dehydrogenase kinase-1 is associated with gastric cancer.

  9. post-mortem brain extracts from patients with Alzheimer disease exhibited a decrease in PDK1 expression compared with nondemented patients.

  10. Pyruvate dehydrogenase kinase 1 is an important regulator of pyruvate dehydrogenase (show PDP Proteins) in clonal pancreatic beta-cells.

Pig (Porcine) Pyruvate Dehydrogenase Kinase, Isozyme 1 (PDK1) interaction partners

  1. Dephosphorylation of PDK1 may be a molecular switch for enhancement of protein tyrosine phosphorylation and flagellar hyperactivation in boar spermatozoa.

PDK1 Protein Profile

Protein Summary

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.

Alternative names and synonyms associated with PDK1

  • pyruvate dehydrogenase kinase, isozyme 1 (PDK1)
  • pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1)
  • pyruvate dehydrogenase kinase, isozyme 1 (Pdk1)
  • pyruvate dehydrogenase kinase, isozyme 1 (pdk1)
  • B830012B01 protein
  • D530020C15Rik protein
  • si:zfos-979f1.3 protein

Protein level used designations for PDK1

pyruvate dehydrogenase kinase, isoenzyme 1 , pyruvate dehydrogenase kinase, isozyme 1 , pyruvate dehydrogenase [lipoamide] kinase isozyme 1, mitochondrial-like , PDH kinase 1 , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial , mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1 , PDK p48 , pyruvate dehydrogenase kinase 1

100218846 Taeniopygia guttata
100402844 Callithrix jacchus
100601990 Nomascus leucogenys
228026 Mus musculus
5163 Homo sapiens
116551 Rattus norvegicus
555840 Danio rerio
425972 Gallus gallus
100286871 Sus scrofa
528655 Bos taurus
476828 Canis lupus familiaris
432080 Xenopus laevis
100064091 Equus caballus
100351323 Oryctolagus cuniculus
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