Browse our PDK3 Proteins (PDK3)

Full name:
Pyruvate Dehydrogenase Kinase, Isozyme 3 Proteins (PDK3)
On are 4 Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3) Proteins from 3 different suppliers available. Additionally we are shipping PDK3 Antibodies (86) and many more products for this protein. A total of 97 PDK3 products are currently listed.
2610001M10Rik, AI035637, PDK3
list all proteins Gene Name GeneID UniProt
PDK3 236900 Q922H2
PDK3 5165 Q15120
Rat PDK3 PDK3 296849  

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Mouse (Murine) Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3) interaction partners

Human Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3) interaction partners

  1. We have identified a p.R158H PDK3 mutation in a Korean X-linked dominant Charcot-Marie-Tooth type 6 family

  2. Accordingly, elevated levels of PDK1, PDK3, and PKM2 and reduced PK activity could be observed in iPSCs and human embryonic stem cells in the undifferentiated state

  3. Reduced pyruvate flux due to R158H mutant PDK3-mediated hyper-phosphorylation of the pyruvate dehydrogenase (show PDP Proteins) complex is the underlying pathogenic cause of peripheral neuropathy in X-linked dominant Charcot-Marie-Tooth disease.

  4. Findings suggest the HIF-1 (show HIF1A Proteins)/PDK3 bioenergetic pathway as a new target for therapeutic intervention in metastatic melanoma.

  5. analysis of residues in L2 and residues in the C-terminal region and the lipoyl-binding pocket of PDK3 which are critical determinants for the cross-talk between L2 and PDK3, which up-regulates PDK3 activity

  6. PDK2 (show PDK2 Proteins), PDK3 and PDK4 (show PDK4 Proteins) are primary PPARbeta (show PPARD Proteins)/delta target genes in humans underlining the importance of the receptor in the control of metabolism

  7. Distinct structural mechanisms for inhibition of PDK3 by AZD7545, dichloroacetate, and radicol.

  8. increased PDK3 expression due to elevated HIF-1alpha (show HIF1A Proteins) in cancer cells may play critical roles in metabolic switch during cancer progression and chemoresistance in cancer therapy

PDK3 Protein Profile

Protein Summary

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PDK3

  • pyruvate dehydrogenase kinase, isozyme 3a (pdk3a)
  • pyruvate dehydrogenase kinase, isozyme 3 (PDK3)
  • pyruvate dehydrogenase kinase, isozyme 3 (pdk3)
  • pyruvate dehydrogenase kinase, isozyme 3 (LOC100226102)
  • pyruvate dehydrogenase kinase, isoenzyme 3 (Pdk3)
  • pyruvate dehydrogenase kinase, isozyme 3 (Pdk3)
  • 2610001M10Rik protein
  • AI035637 protein
  • PDK3 protein

Protein level used designations for PDK3

pyruvate dehydrogenase kinase, isozyme 3 , pyruvate dehydrogenase kinase, isoenzyme 3 , pyruvate dehydrogenase kinase 3 , pyruvate dehydrogenase [lipoamide] kinase isozyme 3, mitochondrial-like , [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial , pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial , Pyruvate dehydrogenase kinase 3

560068 Danio rerio
740576 Pan troglodytes
100060791 Equus caballus
100135009 Xenopus (Silurana) tropicalis
100226102 Taeniopygia guttata
100388325 Callithrix jacchus
236900 Mus musculus
5165 Homo sapiens
418595 Gallus gallus
480868 Canis lupus familiaris
510841 Bos taurus
296849 Rattus norvegicus
100153858 Sus scrofa
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