You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our PDPK1 Proteins (PDPK1)

Full name:
3-phosphoinositide Dependent Protein Kinase-1 Proteins (PDPK1)
On are 12 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Proteins from 7 different suppliers available. Additionally we are shipping PDPK1 Antibodies (252) and PDPK1 Kits (14) and many more products for this protein. A total of 301 PDPK1 products are currently listed.
1210, BG02759, CD79B, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, LOC100304995, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787
list all proteins Gene Name GeneID UniProt
PDPK1 18607 Q9Z2A0
PDPK1 5170 O15530
PDPK1 81745 O55173

Show all synonyms

PDPK1 Proteins (PDPK1) by Origin

Select your origin of interest

More Proteins for PDPK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (show CDK7 Proteins) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Data show that the phosphoinositide-dependent kinase 1 (PDK1)-p90 (show GPAM Proteins) kDa ribosomal S6 kinases (Rsks) Rsk1 (show RPS6KA1 Proteins)/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.

  2. Data illustrate a critical role for PDK1 in transducing inhibitory signals on eosinophil effector function. Stimulation of EP4 (show PTGER4 Proteins) receptors caused PDK1 phosphorylation at Ser396 and induced PI3K-dependent nuclear translocation of PDK1.

  3. Using a PDK1 conditional deletion MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) murine AML (show RUNX1 Proteins) model, we revealed that the deletion of PDK1 prolonged the survival of AML (show RUNX1 Proteins) mice by inducing LSC (show ARHGEF1 Proteins) apoptosis

  4. The B cell receptor and a subset of cytokine receptors require PDK1 for B cell generation in the bone marrow as well as for mature B cell survival and activation.

  5. These results demonstrated that PDK1 and mTORC2 (show CRTC2 Proteins) synergistically promote postnatal heart growth and maintain heart function in postnatal mice.

  6. these results indicate that activation of PDK-1 (show PDK1 Proteins) maintains mouse embryonic stem cell self-renewal in a protein kinase B (show AKT1 Proteins) dependent manner in the absence of leukemia inhibitory factor (show LIF Proteins).

  7. PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.

  8. cytoplasmic localization of PDK1 correlated only with early-stage, low-risk tumors, whereas nuclear PDK1 localization correlated with high-risk tumors

  9. PDK1 regulation of mTOR (show FRAP1 Proteins) and hypoxia-inducible factor 1 (show HIF1A Proteins) integrate metabolism and migration of CD8 (show CD8A Proteins)+ T cells.

  10. Pdk1 deletion in bone marrow-derived macrophages abolished insulin (show INS Proteins) and interleukin-4 (show IL4 Proteins) induction of genes involved in alternative macrophage activation.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Decreased PDK1 (show PDK1 Proteins) level is closely associated with reduced Akt (show AKT1 Proteins)/cyclin D1 (show CCND1 Proteins) activity.

  2. MiR (show MLXIP Proteins)-138 regulation of PI3K (show PIK3CA Proteins) signaling in ASMCs by altering the expression of PDK1 (show PDK1 Proteins).

  3. Dephosphorylation of PDK-1 (show PDK1 Proteins) and the resulting changes to Akt (show AKT1 Proteins) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  4. Data suggest that claudin-18 (show CLDN18 Proteins) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (show CDK7 Proteins)-1 and proto-oncogene (show RAB1A Proteins) protein c-akt (Akt (show AKT1 Proteins)).

  5. DK1 inhibits the formation of the TAK1 (show MAP3K7 Proteins)-TAB2 (show TAB2 Proteins)-TRAF6 (show TRAF6 Proteins) complex and leads to the inhibition of TRAF6 (show TRAF6 Proteins) ubiquitination.

  6. Data show that NSC156529 inhibits the interaction of endogenous serine/threonine kinase (show TLK2 Proteins) AKT (AKT1 (show AKT1 Proteins)) and 3-phosphoinositide dependent protein kinase-1 (PDPK1) proteins.

  7. PDK1 (show PDK1 Proteins) functions as a tumor promoter in human gallbladder cancer by upregulating JunB (show JUNB Proteins), promoting epithelial mesenchymal transformation, and cell migration.

  8. PGE2 increases normal bronchial epithelial cell proliferation through increased PDK1 (show PDK1 Proteins) gene expression that is dependent on EP4 (show PTGER4 Proteins) and induction of c-Jun (show JUN Proteins).

  9. data show that PDK1 (show PDK1 Proteins) played a pivotal role in the growth of angiosarcoma cells.

  10. findings show that PDK1 (show PDK1 Proteins)-PLK1-MYC (show MYC Proteins) signaling is critical for cancer cell growth and survival; PDK1 (show PDK1 Proteins)-PLK1-MYC (show MYC Proteins) signaling induces an embryonic stem cell-like gene signature associated with aggressive tumor behaviors and is a robust signaling axis driving cancer stem cell self-renewal

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (show PIK3C3 Proteins) (PI3K)

PDPK1 Protein Profile

Protein Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • Phosphoinositide-dependent kinase 1 (Pdk1)
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1)
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a)
  • CD79b molecule, immunoglobulin-associated beta (CD79B)
  • CD79b molecule, immunoglobulin-associated beta (CD79b)
  • CD79b (LOC100304995)
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1)
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1)
  • 3-phosphoinositide dependent protein kinase-1 (PDPK1)
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1)
  • Protein PDK-1 (pdk-1)
  • 1210 protein
  • BG02759 protein
  • CD79B protein
  • CG1201 protein
  • CG1210 protein
  • Dmel\\CG1210 protein
  • dPDK-1 protein
  • dPDK1 protein
  • dSTPK61 protein
  • LOC100304995 protein
  • MGC82080 protein
  • PDK protein
  • PDK-1 protein
  • Pdk1 protein
  • PDK1/Pk61C protein
  • pdpk1 protein
  • PDPK2 protein
  • pk61c protein
  • Pk61C/PDK1 protein
  • PRO0461 protein
  • zgc:153787 protein

Protein level used designations for PDPK1

CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase , 3-phosphoinositide dependent protein kinase-1 , 3-phosphoinositide-dependent protein kinase 1 , B-cell antigen receptor complex-associated protein beta chain , CD79b molecule, immunoglobulin-associated beta , CD79b , Pkb kinase , mPDK1 , PkB kinase like gene 1 , pkB kinase , protein kinase B kinase

38017 Drosophila melanogaster
444529 Xenopus laevis
779524 Xenopus (Silurana) tropicalis
768202 Danio rerio
419940 Gallus gallus
454773 Pan troglodytes
100026330 Monodelphis domestica
100304995 Ictalurus punctatus
100471131 Ailuropoda melanoleuca
100380750 Salmo salar
18607 Mus musculus
5170 Homo sapiens
81745 Rattus norvegicus
100192445 Sus scrofa
416588 Gallus gallus
479875 Canis lupus familiaris
100138102 Bos taurus
180475 Caenorhabditis elegans
Selected quality suppliers for PDPK1 Proteins (PDPK1)
Did you look for something else?