Browse our PDPK1 Proteins (PDPK1)

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3-phosphoinositide Dependent Protein Kinase-1 Proteins (PDPK1)
On are 28 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Proteins from 12 different suppliers available. Additionally we are shipping PDPK1 Antibodies (467) and PDPK1 Kits (25) and many more products for this protein. A total of 551 PDPK1 products are currently listed.
1210, BG02759, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787
list all proteins Gene Name GeneID UniProt
PDPK1 81745 O55173
PDPK1 5170 O15530
PDPK1 18607 Q9Z2A0

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PDPK1 Proteins (PDPK1) by Origin

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Top referenced PDPK1 Proteins

  1. Human PDPK1 Protein expressed in Escherichia coli (E. coli) - ABIN666881 : Xie, Yuan, Yin, Zeng, Bai, Glazer: 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases. in BMC cancer 2006 (PubMed)
    Show all 2 references for 666881

  2. Human PDPK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005169 : Kato, Li, Chuang, Chuang: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. in Structure (London, England : 1993) 2007 (PubMed)
    Show all 2 references for 2005169

More Proteins for PDPK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (show CDK7 Proteins) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.

  2. PDK1 was highly expressed in synovia of collagen-induced-arthritis mice com (show IL1B Proteins)pared to (show IL6 Proteins)control. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up- (show RPS6KA3 Proteins)regulated in CIA compared with normal. This indicated that PDK1/RSK2 may participate in inflammatory pro (show TNF Proteins)gress of RA.

  3. PDK1 is required for Ca(2 (show CA2 Proteins)+)-dependent platelet activation on stimulation of collagen receptor (show ITGA2 Proteins) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.

  4. In conclusion, we have identified that ARL15 acts as an insulin (show INS Proteins)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Proteins)/PDPK1/AKT (show AKT1 Proteins) insulin (show INS Proteins) pathway by interacting with its GAP ASAP2 (show ASAP2 Proteins) and activating PDPK1. This research may provide new insights into GTPase (show RACGAP1 Proteins)-mediated insulin (show INS Proteins) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Proteins) sensitizati

  5. Only when suboptimal doses of Akt (show AKT1 Proteins)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (show NOTCH1 Proteins) inhibition was seen. We conclude that the Akt (show AKT1 Proteins) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (show AKT1 Proteins) signaling.

  6. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (show NFKB1 Proteins).

  7. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  8. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  9. PDK1 is an important regulator in arterial thrombosis formation.

  10. PDK1 is essential for BCR (show BCR Proteins)-induced signal transduction to Foxo (show FOXO3 Proteins) and NF-kappaB (show NFKB1 Proteins) and is indispensable for both resting and activated B cell survival.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Highly expressed PDK1 (show PDK1 Proteins) could promote cell invasion and secretion of IL-1beta (show IL1B Proteins) and IL-6 (show IL6 Proteins) in human rheumatoid arthritis synovial MH7A cells. Inhibition of RSK2 (show RPS6KA3 Proteins) reduced the PDK1 (show PDK1 Proteins)-induced cell invasion and cytokines secretion in MH7A cells. In response to TNF-alpha (show TNF Proteins), PDK1 (show PDK1 Proteins) could phosphorylate RSK2 (show RPS6KA3 Proteins) and activated RSK2 (show RPS6KA3 Proteins), then promoting the activation of NF-kappaB (show NFKB1 Proteins).

  2. In cancer cells resistant to PI3Kalpha inhibition, PDK1 blockade restores sensitivity to these therapies. SGK1, which is activated by PDK1, contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2.

  3. Results suggest that Ser (show SIGLEC1 Proteins)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (show PDK1 Proteins)-PKCtheta (show PRKCQ Proteins);-mediated T cell activation.

  4. Elevated expression of PDK1 (show PDK1 Proteins) was an independent negative prognostic factor of gastric carcinoma.

  5. miR (show MLXIP Proteins)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (show PDK1 Proteins).

  6. miR (show MLXIP Proteins)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (show PDK1 Proteins) expression.

  7. Decreased PDK1 (show PDK1 Proteins) level is closely associated with reduced Akt (show AKT1 Proteins)/cyclin D1 (show CCND1 Proteins) activity.

  8. MiR (show MLXIP Proteins)-138 regulation of PI3K (show PIK3CA Proteins) signaling in ASMCs by altering the expression of PDK1 (show PDK1 Proteins).

  9. Dephosphorylation of PDK-1 (show PDK1 Proteins) and the resulting changes to Akt (show AKT1 Proteins) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  10. Data suggest that claudin-18 (show CLDN18 Proteins) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (show CDK7 Proteins)-1 and proto-oncogene (show RAB1A Proteins) protein c-akt (Akt (show AKT1 Proteins)).

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. miR (show MYLIP Proteins)-375 directly targeted PDK1 (show PDK1 Proteins) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (show PIK3C3 Proteins) (PI3K)

PDPK1 Protein Profile

Protein Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • 3-phosphoinositide dependent protein kinase-1 (PDPK1)
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1)
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1)
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1)
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a)
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1)
  • Phosphoinositide-dependent kinase 1 (Pdk1)
  • Protein PDK-1 (pdk-1)
  • 1210 protein
  • BG02759 protein
  • CG1201 protein
  • CG1210 protein
  • Dmel\\CG1210 protein
  • dPDK-1 protein
  • dPDK1 protein
  • dSTPK61 protein
  • MGC82080 protein
  • PDK protein
  • PDK-1 protein
  • Pdk1 protein
  • PDK1/Pk61C protein
  • pdpk1 protein
  • PDPK2 protein
  • pk61c protein
  • Pk61C/PDK1 protein
  • PRO0461 protein
  • zgc:153787 protein

Protein level used designations for PDPK1

3-phosphoinositide-dependent protein kinase 1 , 3-phosphoinositide dependent protein kinase-1 , pkB kinase , protein kinase B kinase , PkB kinase like gene 1 , Pkb kinase , mPDK1 , CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase

416588 Gallus gallus
444529 Xenopus laevis
479875 Canis lupus familiaris
100138102 Bos taurus
100192445 Sus scrofa
779524 Xenopus (Silurana) tropicalis
81745 Rattus norvegicus
5170 Homo sapiens
18607 Mus musculus
768202 Danio rerio
100380750 Salmo salar
38017 Drosophila melanogaster
180475 Caenorhabditis elegans
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