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Browse our PDPK1 Proteins (PDPK1)

Full name:
3-phosphoinositide Dependent Protein Kinase-1 Proteins (PDPK1)
On www.antibodies-online.com are 23 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) Proteins from 12 different suppliers available. Additionally we are shipping PDPK1 Antibodies (443) and PDPK1 Kits (20) and many more products for this protein. A total of 516 PDPK1 products are currently listed.
Synonyms:
1210, BG02759, CD79B, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, LOC100304995, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787
list all proteins Gene Name GeneID UniProt
PDPK1 18607 Q9Z2A0
PDPK1 5170 O15530
PDPK1 81745 O55173

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PDPK1 Proteins (PDPK1) by Origin

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Top referenced PDPK1 Proteins

  1. Human PDPK1 Protein expressed in Escherichia coli (E. coli) - ABIN666881 : Xie, Yuan, Yin, Zeng, Bai, Glazer: 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases. in BMC cancer 2006 (PubMed)
    Show all 2 references for ABIN666881

  2. Human PDPK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005169 : Kato, Li, Chuang, Chuang: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. in Structure (London, England : 1993) 2007 (PubMed)
    Show all 2 references for ABIN2005169

More Proteins for PDPK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (show CDK7 Proteins) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Only when suboptimal doses of Akt (show AKT1 Proteins)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (show NOTCH1 Proteins) inhibition was seen. We conclude that the Akt (show AKT1 Proteins) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (show AKT1 Proteins) signaling.

  2. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (show NFKB1 Proteins).

  3. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  4. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  5. PDK1 is an important regulator in arterial thrombosis formation.

  6. PDK1 is essential for BCR (show BCR Proteins)-induced signal transduction to Foxo (show FOXO3 Proteins) and NF-kappaB (show NFKB1 Proteins) and is indispensable for both resting and activated B cell survival.

  7. Results suggest that heat shock protein 90 (show HSP90 Proteins) inhibitor radicicol inhibited 3T3-L1 preadipocyte differentiation through affecting the PDK1/Akt (show AKT1 Proteins) pathway.

  8. Inhibition of PDK1 promotes localization of TACE (show ADAM17 Proteins) to the plasma membrane, restores TACE (show ADAM17 Proteins)-dependent alpha-secretase activity and cleavage of APP (show APP Proteins), PrP(C (show PRNP Proteins)) and TNFR1 (show TNFRSF1A Proteins), and attenuates PrP(Sc)- and Abeta (show APP Proteins)-induced neurotoxicity.

  9. Data show that insulin (show INS Proteins) stimulates GLUT4 (show SLC2A4 Proteins) translocation to the cell surface and iglucose uptake in an Akt1 (show AKT1 Proteins)/2-dependent manner; PI3K phosphorylates Thr308 and Ser473 for Akt1 (show AKT1 Proteins) and Ser474 alone for Akt2 (show AKT2 Proteins); and PDK1 phosphorylates Thr308 for Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins).

  10. Direct genetic evidence for the importance of PDK1, in part through FOXO3a (show FOXO3 Proteins)-dependent pathway, in melanoma development and progression.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Results suggest that Ser (show SIGLEC1 Proteins)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (show PDK1 Proteins)-PKCtheta (show PRKCQ Proteins);-mediated T cell activation.

  2. Elevated expression of PDK1 (show PDK1 Proteins) was an independent negative prognostic factor of gastric carcinoma.

  3. miR (show MLXIP Proteins)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (show PDK1 Proteins).

  4. miR (show MLXIP Proteins)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (show PDK1 Proteins) expression.

  5. Decreased PDK1 (show PDK1 Proteins) level is closely associated with reduced Akt (show AKT1 Proteins)/cyclin D1 (show CCND1 Proteins) activity.

  6. MiR (show MLXIP Proteins)-138 regulation of PI3K (show PIK3CA Proteins) signaling in ASMCs by altering the expression of PDK1 (show PDK1 Proteins).

  7. Dephosphorylation of PDK-1 (show PDK1 Proteins) and the resulting changes to Akt (show AKT1 Proteins) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  8. Data suggest that claudin-18 (show CLDN18 Proteins) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (show CDK7 Proteins)-1 and proto-oncogene (show RAB1A Proteins) protein c-akt (Akt (show AKT1 Proteins)).

  9. DK1 inhibits the formation of the TAK1 (show MAP3K7 Proteins)-TAB2 (show TAB2 Proteins)-TRAF6 (show TRAF6 Proteins) complex and leads to the inhibition of TRAF6 (show TRAF6 Proteins) ubiquitination.

  10. Data show that NSC156529 inhibits the interaction of endogenous serine/threonine kinase (show TLK2 Proteins) AKT (AKT1 (show AKT1 Proteins)) and 3-phosphoinositide dependent protein kinase-1 (PDPK1) proteins.

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. miR (show MYLIP Proteins)-375 directly targeted PDK1 (show PDK1 Proteins) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (show PIK3C3 Proteins) (PI3K)

PDPK1 Protein Profile

Protein Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • Phosphoinositide-dependent kinase 1 (Pdk1)
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1)
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a)
  • CD79b molecule, immunoglobulin-associated beta (CD79B)
  • CD79b molecule, immunoglobulin-associated beta (CD79b)
  • CD79b (LOC100304995)
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1)
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1)
  • 3-phosphoinositide dependent protein kinase-1 (PDPK1)
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1)
  • Protein PDK-1 (pdk-1)
  • 1210 protein
  • BG02759 protein
  • CD79B protein
  • CG1201 protein
  • CG1210 protein
  • Dmel\\CG1210 protein
  • dPDK-1 protein
  • dPDK1 protein
  • dSTPK61 protein
  • LOC100304995 protein
  • MGC82080 protein
  • PDK protein
  • PDK-1 protein
  • Pdk1 protein
  • PDK1/Pk61C protein
  • pdpk1 protein
  • PDPK2 protein
  • pk61c protein
  • Pk61C/PDK1 protein
  • PRO0461 protein
  • zgc:153787 protein

Protein level used designations for PDPK1

CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase , 3-phosphoinositide dependent protein kinase-1 , 3-phosphoinositide-dependent protein kinase 1 , B-cell antigen receptor complex-associated protein beta chain , CD79b molecule, immunoglobulin-associated beta , CD79b , Pkb kinase , mPDK1 , PkB kinase like gene 1 , pkB kinase , protein kinase B kinase

GENE ID SPECIES
38017 Drosophila melanogaster
444529 Xenopus laevis
779524 Xenopus (Silurana) tropicalis
768202 Danio rerio
419940 Gallus gallus
454773 Pan troglodytes
100026330 Monodelphis domestica
100304995 Ictalurus punctatus
100471131 Ailuropoda melanoleuca
100380750 Salmo salar
18607 Mus musculus
5170 Homo sapiens
81745 Rattus norvegicus
100192445 Sus scrofa
416588 Gallus gallus
479875 Canis lupus familiaris
100138102 Bos taurus
180475 Caenorhabditis elegans
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