Browse our Proline Rich 5 (Renal) Proteins (PRR5)

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Proline Rich 5 (Renal) Proteins (PRR5)
On are 6 Proline Rich 5 (Renal) (PRR5) Proteins from 3 different suppliers available. Additionally we are shipping Proline Rich 5 (Renal) Antibodies (64) and many more products for this protein. A total of 76 Proline Rich 5 (Renal) products are currently listed.
Arhgap8, AU043908, C030017C09Rik, C78947, FLJ20185k, pp610, Protor-1, protor1, protor2
list all proteins Gene Name GeneID UniProt
PRR5 55615 P85299
PRR5 109270 Q812A5
PRR5 315189 Q5FVG6

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Proline Rich 5 (Renal) Proteins (PRR5) by Origin

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More Proteins for Proline Rich 5 (Renal) Interaction Partners

Human Proline Rich 5 (Renal) (PRR5) interaction partners

  1. mRNA expression analyses revealed PRR5 overexpression in a majority of colorectal tumors but substantial downregulation of PRR5 expression in a subset of breast tumors and reduced expression in two breast cancer cell lines

  2. It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 (show PRR5L Proteins) results in the co-immunoprecipitation of other mTORC2 (show CRTC2 Proteins) subunits, but not Raptor (show RPTOR Proteins), a specific component of mTORC1.

  3. The inhibition of Akt (show AKT1 Proteins) and S6K1 (show RPS6KB1 Proteins) phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (show PDGFRB Proteins) (PDGFRbeta).

Proline Rich 5 (Renal) (PRR5) Protein Profile

Protein Summary

This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.

Alternative names and synonyms associated with Proline Rich 5 (Renal) (PRR5)

  • proline rich 5 (renal) (PRR5)
  • proline rich 5 (renal) (Prr5)
  • proline rich 5 (renal) (prr5)
  • Arhgap8 protein
  • AU043908 protein
  • C030017C09Rik protein
  • C78947 protein
  • FLJ20185k protein
  • pp610 protein
  • Protor-1 protein
  • protor1 protein
  • protor2 protein

Protein level used designations for Proline Rich 5 (Renal) Proteins (PRR5)

Rho GTPase activating protein 8 , proline-rich protein 5 , protein observed with Rictor-1 , protor-1 , Protor-2 homolog

55615 Homo sapiens
109270 Mus musculus
315189 Rattus norvegicus
380036 Xenopus laevis
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