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mRNA expression analyses revealed PRR5 overexpression in a majority of colorectal tumors but substantial downregulation of PRR5 expression in a subset of breast tumors and reduced expression in two breast cancer cell lines
It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 (show PRR5L Proteins) results in the co-immunoprecipitation of other mTORC2 (show CRTC2 Proteins) subunits, but not Raptor (show RPTOR Proteins), a specific component of mTORC1.
The inhibition of Akt (show AKT1 Proteins) and S6K1 (show RPS6KB1 Proteins) phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (show PDGFRB Proteins) (PDGFRbeta).
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Rho GTPase activating protein 8
, proline-rich protein 5
, protein observed with Rictor-1
, Protor-2 homolog