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We found that neither S6K (show RPS6KB1 ELISA Kits)-dependent cell growth nor S6K (show RPS6KB1 ELISA Kits)-Thr (show TRH ELISA Kits)-398 phosphorylation was affected in rictor (show RICTOR ELISA Kits)-null mutants.
RPTOR (regulatory associated protein of mTOR, complex 1) is a novel target of miR (show MLXIP ELISA Kits)-155 in CF lung epithelial cells. The suppression of RPTOR expression and subsequent activation of TGF-beta (show TGFB1 ELISA Kits) signaling resulted in the induction of fibrosis by elevating connective tissue growth factor (CTGF (show CTGF ELISA Kits)) abundance in CF lung epithelial cells.
Data show that mTOR (show FRAP1 ELISA Kits) protein forms a complex with Raptor and estrogen receptor-alpha (ERalpha (show ESR1 ELISA Kits)).
Up-regulation of mTORC1 via raptor by aldosterone is a critical pathobiologic mechanism that controls pulmonary artery smooth muscle cell survival to promote hypertrophic vascular remodeling and pulmonary arterial hypertension.
Hgh mTOR (show FRAP1 ELISA Kits) activity and Rictor (show RICTOR ELISA Kits) overexpression could be markers of a bad prognosis. Combined phosphoprotein and Rictor (show RICTOR ELISA Kits)/Raptor expression evaluation revealed even stronger statistical correlation with prognosis.
revealed more than 170 NFAT (show NFATC1 ELISA Kits)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 ELISA Kits) and NFATc2 (show NFAT1 ELISA Kits) in T cells, such as Raptor, CHEK1 (show CHEK1 ELISA Kits), CREB1 (show CREB1 ELISA Kits), RUNX1 (show RUNX1 ELISA Kits), SATB1 (show SATB1 ELISA Kits), Ikaros (show IKZF1 ELISA Kits), and Helios (show ZNFN1A2 ELISA Kits).
In this study we began by validating the expression of four main mTOR (show FRAP1 ELISA Kits) pathway components, mTOR (show FRAP1 ELISA Kits), DEPTOR (show DEPTOR ELISA Kits), rictor (show RICTOR ELISA Kits) and raptor, at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Our results demonstrate for the first time that the expression quantitative trait loci of RPTOR, rs7502563, is susceptible to glioma
The positive regulation of mTORC1 activity by NPRL2 (show NPRL2 ELISA Kits) is mediated through NPRL2 (show NPRL2 ELISA Kits) interaction with Raptor.
Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2.
RPTOR was not associated with bipolar disorder or schizophrenia.
Deletion of Raptor reduced the size of limb bud cells, resulting in overall diminution of the limb bud without affecting skeletal patterning. We then examined the potential role of mTORC1 in chondrogenic differentiation in vitro.
Results provide genetic evidence indicating that mTOR (show FRAP1 ELISA Kits) and Raptor are required for sensory axon regeneration enhanced by peripheral lesions in mice, whereas Rictor (show RICTOR ELISA Kits) plays a minor role. The peripheral lesion activates rapamycin-resistant mTOR (show FRAP1 ELISA Kits) signaling to modulate Stat3 (show STAT3 ELISA Kits) activity and further promotes axon regeneration.
This study demonstrated that Loss of the Rptor gene in mice neural progenitor cells affects normal development in young age and may contribute to alleviate KA seizure-induced behavioral abnormalities, suggesting that raptor protein plays an important role in seizure comorbidities.
These results demonstrate that mTORC1 has an essential role in the meiotic progression and silencing of sex chromosomes in the male germline, based on conditional knockdown of its core component, Raptor.
Rptor/mTORC1 signalling supports germinal center B cell responses at both early and late GC phases during viral infection but does not regulate GCB (show NPR2 ELISA Kits) cell differentiation into memory B cells and plasma cells at the late GC stage.
mitochondrial dysfunction triggers LKB1 (show STK11 ELISA Kits)-mediated AMPK (show PRKAA1 ELISA Kits) activation, which stimulates Sirt2 (show SIRT2 ELISA Kits) phosphorylation, leading to activation of mTOR (show FRAP1 ELISA Kits)-RAPTOR and Glut1 (show SLC2A1 ELISA Kits)-mediated glucose uptake.
inhibiting regulatory-associated protein of mechanistic target of rapamycin (show FRAP1 ELISA Kits) (RPTOR) in hyperoxia settings, limited lung injury by increased autophagy, decreased apoptosis, improved lung architecture, and increased survival.
Raptor knockout mice are lean and insulin (show INS ELISA Kits) resistant with increased energy expenditure, and they are resistant to a high-fat diet.
The findings reveal HDAC5 (show HDAC5 ELISA Kits)-mTORC1 signaling as a novel mechanism in the differential regulation of gastric ghrelin (show GHRL ELISA Kits) and nesfatin-1 (show NUCB2 ELISA Kits).
data suggest that EtOH-induced decreases in protein synthesis in fasted mice may be independent of mTORC1 and MAPK (show MAPK1 ELISA Kits) signaling.
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
, target of rapamycin (TOR)-associated protein
, Raptor family protein
, WD40 repeat-containing protein
, armadillo-like helical domain-containing protein
, p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
, regulatory-associated protein of mTOR
, p150 target of rapamycin (TOR)-scaffold protein