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Mutations in APOPT1, encoding a mitochondrial protein (show COX6B2 Proteins), cause cavitating leukoencephalopathy with cytochrome c (show CYCS Proteins) oxidase deficiency.
These data indicate that the inhibition of Apop-1-induced death by IGF-1 (show IGF1 Proteins) is mediated by the activation of the PI3K/Akt (show AKT1 Proteins) signaling pathway.
Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade (By similarity).
UPF0671 protein C14orf153
, apoptogenic protein 1, mitochondrial
, UPF0671 protein C14orf153 homolog