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Loss of BOK is associated with non-small-cell lung carcinoma.
These results not only establish Bok as a Bak (show BAK1 ELISA Kits)- and Bax (show BAX ELISA Kits)-independent apoptosis inducer, but also suggest a potential impact of Bok expression in ovarian cancer therapy.
Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 (show BCL2 ELISA Kits) family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 (show DNAJB12 ELISA Kits) is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 (show DNAJB12 ELISA Kits) = DnaJ (Hsp40 (show DNAJB1 ELISA Kits)) homolog (show DNAJB4 ELISA Kits), subfamily B (show CYP ELISA Kits), member 12)
Data suggest that hypoxia-induced expression of BOK in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A (show HIF1A ELISA Kits), HIF2A/EPAS1 (show EPAS1 ELISA Kits), HIF1B/ARNT (show ARNT ELISA Kits)) but is not affected by its antisense transcript.
First evidence for a key role of the BOK-MCL1 (show MCL1 ELISA Kits) system in regulating autophagy in the human placenta, whereby an adverse environment as seen in preeclampsia tilts the BOK-MCL1 (show MCL1 ELISA Kits) balance toward the build-up of isoforms that triggers placental autophagy.
Bok may govern IP3R (show ITPR1 ELISA Kits) cleavage and activity during apoptosis.
The results suggest important roles for Bok and Bcl-X(L (show BCL2L1 ELISA Kits)) in human ovarian development, follicle maturation and apoptosis.
Data conclude that Mtd (show MT1E ELISA Kits)-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd (show MT1E ELISA Kits) found in PE may contribute to increased trophoblast proliferation.
BOK and NOXA (show PMAIP1 ELISA Kits) are essential mediators of p53 (show TP53 ELISA Kits)-dependent apoptosis
A novel Mtd/BOK splice isoform is responsible for trophoblast cell death in pre-eclampsia.
we show that BOK(C) can permeabilize liposomes, and cooperate with cBID, but its role in directly mediating mitochondrial permeabilization is unclear and may underlie a yet to be determined negative regulation.
Bok controls neuronal Ca(2 (show CA2 ELISA Kits)+) homeostasis and bioenergetics in seizure-induced neuronal injury.
Study reports that BCL-2 (show BCL2 ELISA Kits) ovarian killer (BOK) is a bona fide yet unconventional effector of mitochondrial outer membrane permeabilization that can trigger apoptosis in the absence of both BAX (show BAX ELISA Kits) and BAK (show BAK1 ELISA Kits).
findings support a selective and distinguishing role for BOK in regulating the apoptotic response to ER stress, revealing--to our knowledge--the first bona fide apoptotic defect linked to Bok deletion
BOK-deficient mice have no readily discernible abnormalities, and its function therefore remains unresolved.
two proapoptotic Bcl-2 family members Bok and Noxa/Pmaip are directly transcriptionally induced by activated MAL and upon activation of the actin-MAL-SRF pathway
Bok protein have a role that largely overlaps with that of other members of the Bcl-2 (show BCL2 ELISA Kits) family, or may have a function restricted to specific stress stimuli and/or tissues.
Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 (show BCL2 ELISA Kits) family
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family.
bcl-2-related ovarian killer protein homolog B
, bcl-2-related ovarian killer protein homolog A
, BCL2-related ovarian killer
, Bcl-2-related ovarian killer
, bcl-2-like protein 9
, bcl-2-related ovarian killer protein
, apoptosis activator Mtd
, protein matador