Browse our BOK Proteins (BOK)

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BCL2-Related Ovarian Killer Proteins (BOK)
On are 6 BCL2-Related Ovarian Killer (BOK) Proteins from 3 different suppliers available. Additionally we are shipping BOK Antibodies (65) and BOK Kits (5) and many more products for this protein. A total of 87 BOK products are currently listed.
AI847676, AU021146, BCL2L9, bok, Bok-BH3, BOKL, matador, mtd, zgc:64041, zgc:100979
list all proteins Gene Name GeneID UniProt
BOK 666 Q9UMX3
BOK 29884 Q792S6
BOK 51800 O35425

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BOK Proteins (BOK) by Origin

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More Proteins for BOK Interaction Partners

Human BCL2-Related Ovarian Killer (BOK) interaction partners

  1. These results not only establish Bok as a Bak (show BAK1 Proteins)- and Bax (show BAX Proteins)-independent apoptosis inducer, but also suggest a potential impact of Bok expression in ovarian cancer therapy.

  2. Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 (show BCL2 Proteins) family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 (show DNAJB12 Proteins) is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 (show DNAJB12 Proteins) = DnaJ (Hsp40 (show DNAJB1 Proteins)) homolog (show DNAJB4 Proteins), subfamily B, member 12)

  3. Data suggest that hypoxia-induced expression of BOK in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A (show HIF1A Proteins), HIF2A/EPAS1 (show EPAS1 Proteins), HIF1B/ARNT (show ARNT Proteins)) but is not affected by its antisense transcript.

  4. First evidence for a key role of the BOK-MCL1 (show MCL1 Proteins) system in regulating autophagy in the human placenta, whereby an adverse environment as seen in preeclampsia tilts the BOK-MCL1 (show MCL1 Proteins) balance toward the build-up of isoforms that triggers placental autophagy.

  5. Bok may govern IP3R (show ITPR1 Proteins) cleavage and activity during apoptosis.

  6. The results suggest important roles for Bok and Bcl-X(L (show BCL2L1 Proteins)) in human ovarian development, follicle maturation and apoptosis.

  7. Data conclude that Mtd (show MT1E Proteins)-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd (show MT1E Proteins) found in PE may contribute to increased trophoblast proliferation.

  8. BOK and NOXA (show PMAIP1 Proteins) are essential mediators of p53 (show TP53 Proteins)-dependent apoptosis

  9. A novel Mtd/BOK splice isoform is responsible for trophoblast cell death in pre-eclampsia.

  10. Studies showed that hBok was distributed in both the cytosol and intracellular membranes of healthy cells.

Mouse (Murine) BCL2-Related Ovarian Killer (BOK) interaction partners

  1. we show that BOK(C) can permeabilize liposomes, and cooperate with cBID, but its role in directly mediating mitochondrial permeabilization is unclear and may underlie a yet to be determined negative regulation.

  2. Bok controls neuronal Ca(2 (show CA2 Proteins)+) homeostasis and bioenergetics in seizure-induced neuronal injury.

  3. Study reports that BCL-2 (show BCL2 Proteins) ovarian killer (BOK) is a bona fide yet unconventional effector of mitochondrial outer membrane permeabilization that can trigger apoptosis in the absence of both BAX (show BAX Proteins) and BAK (show BAK1 Proteins).

  4. findings support a selective and distinguishing role for BOK in regulating the apoptotic response to ER stress, revealing--to our knowledge--the first bona fide apoptotic defect linked to Bok deletion

  5. BOK-deficient mice have no readily discernible abnormalities, and its function therefore remains unresolved.

  6. Bok may govern IP3R (show ITPR1 Proteins) cleavage and activity during apoptosis.

  7. two proapoptotic Bcl-2 family members Bok and Noxa/Pmaip are directly transcriptionally induced by activated MAL and upon activation of the actin-MAL-SRF pathway

  8. Bok protein have a role that largely overlaps with that of other members of the Bcl-2 (show BCL2 Proteins) family, or may have a function restricted to specific stress stimuli and/or tissues.

  9. Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 (show BCL2 Proteins) family

BOK Protein Profile

Protein Summary

The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family.

Alternative names and synonyms associated with BOK

  • BCL2-related ovarian killer b (bokb)
  • BCL2-related ovarian killer a (boka)
  • BCL2-related ovarian killer (BOK)
  • BCL2-related ovarian killer (LOC100220512)
  • BCL2-related ovarian killer (Bok)
  • BCL2-related ovarian killer protein (Bok)
  • AI847676 protein
  • AU021146 protein
  • BCL2L9 protein
  • bok protein
  • Bok-BH3 protein
  • BOKL protein
  • matador protein
  • mtd protein
  • zgc:64041 protein
  • zgc:100979 protein

Protein level used designations for BOK

bcl-2-related ovarian killer protein homolog B , zBok2 , bcl-2-related ovarian killer protein homolog A , zBok1 , BCL2-related ovarian killer , Bcl-2-related ovarian killer , bcl-2-like protein 9 , bcl-2-related ovarian killer protein , bcl2-L-9 , hBOK , apoptosis activator Mtd , protein matador

394160 Danio rerio
445218 Danio rerio
701430 Macaca mulatta
768266 Felis catus
100220512 Taeniopygia guttata
666 Homo sapiens
504851 Bos taurus
29884 Rattus norvegicus
395445 Gallus gallus
51800 Mus musculus
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