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Human Cathepsin H Protein expressed in Human - ABIN413149
Murakami, Tolstykh, Bao, Niu, Steuer, Bao, Chang, Espiritu, Bansal, Lam, Otto, Sofia, Furman: Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. in The Journal of biological chemistry 2010
the up-regulation of MMP genes is mediated through degradation of class IIa histone deacetylases (HDACs) by certain cysteine cathepsins (Cts (show TTR Proteins)).
Especially, rs3825932 in CTSH has integrative functional evidence supporting the association with type 1 diabetes mellitus.
p41 (show EPB41 Proteins) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (show IL12A Proteins)/p70 (show ANXA6 Proteins)) during the subsequent maturation of treated dendritic cells.
In conclusion, CTSH/rs3825932 and ERBB3 (show ERBB3 Proteins)/rs2292239 SNPs were associated with reduced risk of progression to proliferative diabetic retinopathy and two-step progression of diabetic retinopathy on the ETDRS scale accordingly.
mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.
The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D
Quantification of immunohistochemistry showed that there is no difference in the global expression of CTSD (show CTSD Proteins), CTSH and CTSK (show CTSK Proteins) between asthmatics and non-asthmatics.
CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 (show ITGAV Proteins) activation and adhesion strength
The processing of procathepsin H is an autocatalytic, multistep process proceeding from an inactive 41kDa (show GPM374 Proteins) pro-form, through a 30kDa (show SAP30 Proteins) intermediate form, to the 28kDa mature form.
CTSH overexpression in a subset hepatoma may be thyroid hormone receptor (show THRA Proteins) dependent and suggests that this overexpression has an important role in hepatoma progression.
Cathepsin H knockout mice show reduced brain levels of (Met)enkephalin and galanin (show GAL Proteins).
cathepsin H is involved in the SP-B production.
In two mouse models of pancreatic islet cancer, deletion of CtsH reduced tumor progression; mechanisms involved impaired angiogenic switching from premalignant state, poor vascularization of tumors, and increased apoptosis.
In proteolipid protein transgenic mice cathepsin H is upregulated primarily in microglia/macrophages of white matter.
Presence of cathepsin H and (bone morphogenetic protein 4)BMP4 (show BMP4 Proteins) in lung or other developing organs suggest that cathepsin H regulates BMP4 (show BMP4 Proteins) proteolysis in morphogenesis.
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.
, cathepsin H-like
, N-benzoylarginine-beta-naphthylamide hydrolase
, cathepsin B3
, cathepsin BA
, pro-cathepsin H
, Cat H