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Ha, Dun, Thangaraju, Duplantier, Dong, Liu, Ganapathy, Smith: Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. in Investigative ophthalmology & visual science 2011
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Human XDH ELISA Kit for Sandwich ELISA - ABIN415193
Li, Zhao, Wang, Gao, Zhao, Fan, Wang: Glutathione S-transferase P1 correlated with oxidative stress in hepatocellular carcinoma. in International journal of medical sciences 2013
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Rat (Rattus) XDH ELISA Kit for Sandwich ELISA - ABIN432964
Li, Tan, Liu, Liu, Wang, Gui, Qin, Deng, Yu, Hu, Chen: Resveratrol ameliorates oxidative stress and inhibits aquaporin 4 expression following rat cerebral ischemia-reperfusion injury. in Molecular medicine reports 2015
Cow (Bovine) XDH ELISA Kit for Sandwich ELISA - ABIN1118118
Altomare, Regazzoni, Parra, Selmin, Rumio, Carini, Aldini: Set-up and application of an analytical approach for the quality control of purified colostrum as food supplement. in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2016
Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury.
crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme [XOR]
Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers.
6,8-dihydroxypurine is effectively converted to uric acid by xanthine oxidase.
Hydrogen peroxide is the major oxidant product of xanthine oxidase
Phe-549, Arg-335, Trp (show TRPC5 ELISA Kits)-336, & Arg-427 form the core of a relay system for the XDH/XO transition.They gate a solvent channel leading toward the FAD (show PSEN1 ELISA Kits) ring.
Results describe the formation of peroxynitrite from the simultaneous reduction of nitrite and oxygen by xanthine oxidase.
Stimulation of XDH conversion to xanthine oxidase may represent a feed-forward mechanism whereby H2O2 can stimulate further production of reactive oxygen species
evidence xanthine oxidase (XO) is regulated by transmembrane secretion of xanthine &/or hypoxanthine to extracellular environment; response of XO to bacteria & bacteria-dependent nitrosative stress demonstrates it is part of mammary gland immune system
Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase: CRYSTAL STRUCTURES IN COMPLEX WITH XANTHINE AND LUMAZINE.
Among cardiac patients, left ventricular hypertrophy, low LVEF, and increased BNP were significantly associated with plasma XOR activity independent of various confounding factors.
we demonstrated that BP rise over time and/or the risk of hypertension are associated with three SNP in the XOR gene: rs2043013, rs11904439, and rs148756340.
Hypoxanthine-xanthine oxidase axis is not involved in the initial phase of clinical transplantation-related ischemia-reperfusion injury in kidney allograft recipients.
Serum XOD activity was higher in type 2 DM patients than in control subjects and was higher in diabetic patients with diabetic peripheral neuropathy than in those without neuropathy.
XOR activity is correlated with insulin (show INS ELISA Kits) resistance, BMI, and subclinical inflammation.
Study showed that DKK3 promotes cell survival during oxidative stress by suppressing XDH expression, thereby abrogating excess reactive oxygen species accumulation and subsequent apoptosis.
Results show XOR strictly modulated at the transcriptional and post-translational levels, and its expression and activity are highly variable in cancer and negatively associated with high malignity grade and a worse prognosis. [review]
XDH and SUCLA2 (show SUCLA2 ELISA Kits) genes associated with thiopurine-induced leukopenia can act in a complex interactive manner in patients with Crohn's disease.
Thyroid stimulating hormone levels are increase in gout patients treated with inhibitors of xanthine oxidoreductase.
The XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 were shown to be associated with hypertension in a rural Chinese population.
NLRP3 inflammasome is decreased and IL-1beta secretion is inhibited in macrophages by hydroxysafflor yellow A and xanthine oxidase
Extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos inhibit xanthine oxidase activity and prevent hyperuricemia.
Our results suggest that a possible relationship between xanthine oxidase-related reactive oxygen species and TRPV1 (show TRPV1 ELISA Kits) may exist during the events preceding eccentric exercise
inflammasome activation accompanied by an increase in xanthine oxidoreductase activity contributed to fat pad inflammation followed by osteoarthritis progression
XOR is abundant in wounds and participates in normal wound healing through effects on ROS (show ROS1 ELISA Kits) production.
XOR regulated macrophage IL-1b secretion upon NLRP3 inflammasome activation via xanthine oxidase derived reactive oxygen species.
Xanthine oxidase inhibitors are potentially potent therapies for patients with NASH (show SAMSN1 ELISA Kits), particularly that associated with hyperuricemia.
these data support a novel function of the XO-NFAT5 (show NFAT5 ELISA Kits) axis in macrophage activation and TLR-induced arthritis
Reduction in XOR gene expression in mice augments lipid accumulation in adipocytes, accompanied by an increase in oxidative stress, and induces obesity with insulin (show INS ELISA Kits) resistance in older age.
Rat Xdh is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase.
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
XDH xanthine dehydrogenase
, xanthine oxidase
, xanthine dehydrogenase
, Xanthine dehydrogenase/oxidase
, xanthine dehydrogenase/oxidase-like
, Xanthine dehydrogenase
, xanthine dehydrogenase/oxidase
, xanthene dehydrogenase
, xanthine oxidoreductase