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our study reveals a previously unappreciated role of reduced BLK (show BIK ELISA Kits) expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
BLK (show BIK ELISA Kits) risk alleles confer susceptibility to systemic lupus erythematosus through the dysregulation of a proinflammatory cytokine network.
this study has revealed a previously unappreciated role for Blk (show BIK ELISA Kits) in the development and activation of MZ B cells
BCR-ABL (show ABL1 ELISA Kits) downregulates the Blk (show BIK ELISA Kits) gene (encoding B-lymphoid kinase) through c-Myc (show MYC ELISA Kits) in leukemic stem cells in chronic myeloid leukemia (show BCL11A ELISA Kits)
Data suggest a role of tyrosine kinase (show TYRO3 ELISA Kits) Btk (show BTK ELISA Kits) in the regulation of immune cell unctions and innate inflammatory response.
Analysis of Blk (show BIK ELISA Kits)-deficient mice reveals that Blk (show BIK ELISA Kits) is required for the development of IL-17 (show IL17A ELISA Kits)-producing gammadelta T cell effectors and plays a role in regulating thymus cellularity during ontogeny.
sustained activation of Blk (show BIK ELISA Kits) induces responses normally associated with the pre-BCR (show BCR ELISA Kits).
Blk (show BIK ELISA Kits), being exceptionally highly expressed in the initial segment, is suggested to have a role in the differentiation of this segment of the epididymis.
rs13277113 GA genotype of BLK is more frequent in Systemic Lupus Erythematosus patients and may have a role in low gene expression and increased flares
current meta-analysis suggested that FAM167A-BLK rs2736340 polymorphism is associated with several autoimmune diseases
the SNPs in TNFSF4 and FAM167A-BLK may be involved in asthma and allergic rhinitis gene risk in the Han Chinese cohort.
The systemic lupus erythematosus variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 (show BANK1 ELISA Kits) through impairment of the SH3 domain (show ITSN1 ELISA Kits) function.
Report a novel BLK gene variant in common variable immunodeficiency-patients that causes suppressed B-cell proliferation and reduced ability of B-cells to elicit antigen-specific CD4 (show CD4 ELISA Kits)(+) T-cell responses.
A major mechanism underlying the BLK association with autoimmune disease involves lowered thresholds for basal B cell receptor signaling, enhanced B cell-T cell interactions, and altered patterns of isotype switching.
our study reveals a previously unappreciated role of reduced BLK expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
Results support previous findings that vaiants in the RHOB and FAM167A-BLK genes may be associated with susceptibility to systemic sclerosis.
These results place Blk upstream of the p190RhoGAP (show GRLF1 ELISA Kits)-RhoA (show RHOA ELISA Kits) pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 ELISA Kits)-triggered invasion.
Report role of BLK genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
B lymphoid kinase
, tyrosine-protein kinase Blk
, B lymphoid tyrosine kinase
, tyrosine-protein kinase Blk-like
, b lymphocyte kinase
, BLK nonreceptor tyrosine kinase