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association between SNP 63 of CAPN10 and gestational diabetes mellitus is only significant in the heterozygous model
There were significant differences between the type 2 diabetes mellitus patients and controls in the risk allele distributions of rs3792267 (CAPN10) (P = 0.002), rs1501299 (APM1) (P = 0.017), and rs3760776 (FUT6 (show FUT6 ELISA Kits)) (P = 0.031).
The study results were suggestive of a positive association between Gly972Arg of IRS1 (show IRS1 ELISA Kits) and PCOS in the south Indian population, while INS (show INS ELISA Kits), IRS2 (show IRS2 ELISA Kits), PPAR-G (show ARF6 ELISA Kits) and CAPN10 failed to show any association with PCOS in our studied population.
These findings indicate that the Calpain-10 SNP 43 may be related to obstructive sleep apnea/hypopnea syndrome with ischemic stroke, with SNP 43 GG genotype as a risk factor for obstructive sleep apnea/hypopnea with ischemic stroke
Subjects with the GG genotype of the rs2975762 variant of the CAPN10 gene were better responders to dietary intervention, showing increased HDL (show HSD11B1 ELISA Kits)-C concentrations from the first month of treatment
due to its association with androgen excess in phenotype A, CAPN 10 gene polymorphism UCSNP-43 could be used as a genetic marker for CVD in young PCOS women.
genetic association studies in Asian populations: Data suggest that an SNP in CAPN10 (SNP43 G>A, rs3792267) is associated with type 2 diabetes in Asian populations, especially in Chinese populations. [META-ANALYSIS]
SNP-63 and indel-19 variant of the CAPN10 gene do not represent a risk factor for polycystic ovary syndrome in Mexican women of reproductive age.
Data indicate no association between calpain 10 (CAPN10) polymorphisms and type 2 diabetes mellitus.
121 haplotype and 122/121 haplotype combination of SNP-19, -44 and -63 in the Calpain-10 gene are associated with the development of type 2 diabetes in Turkish patients.
Capn10 plays an important role in regulating obesity and diabetes in mice.
calpain-derived Htt (show HTT ELISA Kits) fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis
calpain-10 has a role in beta-cell survival and is suppressed by RyR2 (show RYR2 ELISA Kits)
These results provide evidence that several previously postulated splice variants of calpain 10 are localized to the mitochondria in kidneys of rabbits, rats, and mice.
Calpain 10 levels specifically decrease in kidney tissues when renal function decreases.
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation\; domain II, the protease domain\; domain III, a linker domain of unknown function\; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.
, calcium-activated neutral proteinase 10
, calpain-like protease CAPN10
, CANP 10
, calpain 8