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Subjects with the GG genotype of the rs2975762 variant of the CAPN10 gene were better responders to dietary intervention, showing increased HDL (show HSD11B1 Proteins)-C concentrations from the first month of treatment
due to its association with androgen excess in phenotype A, CAPN 10 gene polymorphism UCSNP-43 could be used as a genetic marker for CVD in young PCOS women.
genetic association studies in Asian populations: Data suggest that an SNP in CAPN10 (SNP43 G>A, rs3792267) is associated with type 2 diabetes in Asian populations, especially in Chinese populations. [META-ANALYSIS]
SNP-63 and indel-19 variant of the CAPN10 gene do not represent a risk factor for polycystic ovary syndrome in Mexican women of reproductive age.
Data indicate no association between calpain 10 (CAPN10) polymorphisms and type 2 diabetes mellitus.
121 haplotype and 122/121 haplotype combination of SNP-19, -44 and -63 in the Calpain-10 gene are associated with the development of type 2 diabetes in Turkish patients.
Different mutations in CAPN10 have already been found in three independent Iranian families
This work confirms the association of CAPN10 gene with metabolic components in PCOS and highlights the role of haplotypes as strong and efficient genetic markers.
The present study provides the first observation of an association between a variant in CAPN10 gene and the response to metformin therapy in patients with type 2 diabetes
Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight in Colombian patients 10-18 years of age even those with physically active lifestyles.
Capn10 plays an important role in regulating obesity and diabetes in mice.
calpain-derived Htt (show HTT Proteins) fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis
calpain-10 has a role in beta-cell survival and is suppressed by RyR2
These results provide evidence that several previously postulated splice variants of calpain 10 are localized to the mitochondria in kidneys of rabbits, rats, and mice.
Calpain 10 levels specifically decrease in kidney tissues when renal function decreases.
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation\; domain II, the protease domain\; domain III, a linker domain of unknown function\; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.
, calcium-activated neutral proteinase 10
, calpain-like protease CAPN10
, CANP 10
, calpain 8