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The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87).
Genotype and allele frequencies of rs29230 in GABR1 were significantly different between cases and controls, especially for male patients, for obstructive sleep apnea risk in Chinese Han population.
presynaptic gamma-aminobutyric acid type B receptor deficits contribute to altered neuronal excitability in fragile X (show FMR1 Proteins) syndrome
Results show that GABBR1 minor genotypes/alleles were protective against risk for alcoholism in 3 ethnically diverse cohorts.
Cell surface ubiquitination precedes endocytosis, after which USP14 acts as an ubiquitin-binding protein that targets the ubiquitinated GABA B receptor to lysosomal degradation and promotes its deubiquitination.
GABA(B)R stimulation promotes chemotaxis in RBL cells which is dependent on signaling via PI3-K/Akt, Src kinases and on rearrangement of both microtubules and actin cytoskeleton.
GABBR1 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2 (show CA2 Proteins)+)]i via a Gi/o-coupled receptor pathway and a phospholipase C (show PLC Proteins) activation pathway.
GABBR1 protein involved in phenylthiourea bitter taste detection.
Authors suggest GABBR1, GABA receptor B1, is implicated in schizophrenia based on a Human endogenous retrovirus long terminal repeat (HERV-W LTR) in the regulatory region of GABBR1.
GABA may inhibit the growth of cholangiocarcinoma QBC939 cells through the GABAB receptor, and the anti-cancer effects may be partly mediated via the JAK (show JAK3 Proteins)/STAT3 (show STAT3 Proteins) pathway
These data suggest that GABA, acting through both presynaptic GABAA (show GABRg1 Proteins) and GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result not possible from activation of either receptor type alone
These results suggest a role for GABAB receptor in Fmrp (show FMR1 Proteins) regulation and a potential interest of GABAB receptor signaling in Fragile X (show FMR1 Proteins) syndrome improvement.
Activation of GABA(B) or mGlu2 (show GRM2 Proteins)/3 receptors inhibited both evoked presynaptic Ca(2 (show CA2 Proteins)+) transients and striatal field potentials.
Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma (show PRKCG Proteins) but decreased that of GABABR1 and GABABR2 (show GABBR2 Proteins) at both protein and mRNA levels in the CNC
GABAB(1) receptor subunit isoforms differentially regulate the deleterious effects of stress and, thus, may be important therapeutic targets for the treatment of depression
Results establish an endogenous GABA/GABAB1 feedback mechanism that keeps TRPV1 (show TRPV1 Proteins)-mediated pain hypersensitivity in check.
The Gabbr1 has an important role in mediating the anxiety-related effects induced by nicotine.
Sex differences in reproductive genes Gnrh1 (show GNRH1 Proteins), Gad1 (show GAD1 Proteins), and Kiss1 (show KISS1 Proteins) are critically disturbed in GABAB1-deficient mice, probably altering the organization and development of neural circuits governing the reproductive axis.
GABAB signaling may normally directly or indirectly inhibit Kiss1 (show KISS1 Proteins) expression, particularly in the bed nucleus of the stria terminalis and medial amygdala
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic
gamma-aminobutyric acid (GABA) B receptor, 1
, gamma-aminobutyric acid type B receptor subunit 1
, GABA-B receptor 1
, GABAB, subunit 1c
, seven transmembrane helix receptor
, GABA-BR1b receptor
, bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a)
, gamma-aminobutyric acid (GABA-B) receptor, 1
, gamma-aminobutyric acid (GABA) B receptor 1
, gamma-aminobutyric acid B receptor 1