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L-trp (show TBPL1 Proteins) is a luminal regulator of CCK (show CCK Proteins) release with effects on gastric emptying, an effect that could be mediated by CCK (show CCK Proteins). L-trp's effect on GLP-1 (show GCG Proteins) secretion is only minor. At the doses given, the two amino acids did not affect subjective appetite feelings.
The effects of GLP-1 (show GCG Proteins)-based therapies on blood glucose in type 2 diabetics are not mediated through microvascular responses.
Endogenous GLP1 (show GCG Proteins) is involved in the central regulation of feeding by affecting central responsiveness to palatable food consumption.
Data show that 6 of 20 primary pancreatic neuroendocrine tumors (PNETs) had positive staining for multiple hormones gastrin (show GAST Proteins), insulin (show INS Proteins), glucagon (show GCG Proteins), and somatostatin (show SST Proteins), and positive expression of 1 or more hormones was found in 9 of 12 nonfunctioning PNETs [NF-PNETs]) patients.
Glucagon-like Peptide-1 (show GCG Proteins) Analogues Inhibit Proliferation and Increase Apoptosis of Human Prostate Cancer Cells
The GLP-1 (show GCG Proteins) secretion after 75 g OGTT was impaired in newly diagnosed T2DM patients, inversely proportional to insulin (show INS Proteins) resistance and hyperglycemia, and positively correlated with beta-cell function and insulin (show INS Proteins) sensitivity.
GLP-1 (show GCG Proteins) secretion increased in response to inflammatory stimuli in humans, which was associated to parameters of glucose metabolism and best predicted by IL6 (show IL6 Proteins).
Among young and healthy adults, GLP-1 (show GCG Proteins) levels are strongly and independently related to body fat mass especially in men, but not body mass index or waist circumference.
Glucagon (show GCG Proteins) circulates in patients without a pancreas and glucose stimulation of the gastrointestinal tract elicits significant hyperglucagonemia in these patients.
There is minor contribution of endogenous GLP-1 and GLP-2 to postprandial lipemia in obese men.
Results suggest that GLP-2 (show GCG Proteins) protected and improved memory function in LPS (show TLR4 Proteins)-treated mice, and also had anxiolytic effects due to changes in the 5-HT (show DDC Proteins) system.
Report gastrointestinal GLP-2 receptor andl limited utility of GLP-2 in the management of inflammatory intestinal disorders.
GLP-2 (show GCG Proteins) plays a key physiological role in the control of hepatic glucose production through activating PI3K-dependent modulation of membrane excitability and nuclear transcription of POMC (show POMC Proteins) neurons in the brain.
Data suggest a role for endogenous GLP2 (glucagon-like peptide-2 (show GCG Proteins)) and GLP2R in adaptation of mucosa of duodenum and jejunum to high-fat diet; results suggest dysregulation of GLP2/GLP2R signaling in obesity due to prolonged high-fat diet.
The data indicated that CNS GLP-2 receptor plays a physiological role in the control of feeding behavior and gastric emptying and that this is mediated probably through the melanocortin system.
Data suggest that the Vip (show Vip Proteins) gene is not required for induction of a gene expression program linked to small bowel growth after enhancement of GLP-2 receptor signaling.
Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis
Data show that the GLP-2R is expressed by inhibitory and excitatory neurons, and inhibits the muscle contractility likely by decreasing cholinergic neurotransmission and increasing nitric oxide production.
GLP-2R is not critical for the stimulation/suppression of glucagon (show GCG Proteins) secretion or glucose homeostasis in normal or lean diabetic mice. In obese mice GLP-2R signaling mediates the normal islet adaptive response required to maintain glucose homeostasis.
Glucagon-like peptide-2 (show GCG Proteins) potentiates L-type voltage-gated Ca(2 (show CA2 Proteins)+) channels activity through activating cAMP-dependent protein kinase A signaling, partially stimulating glucose uptake by primary cultured hippocampal neurons.
data demonstrate that cattle express proglucagon (show GCG Proteins) and glucagon-like peptide 2 receptor mRNA primarily in small intestinal and colon tissues
The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).
glucagon-like peptide 2 receptor
, glicentin-related polypeptide
, glucagon-like peptide 1
, glucagon-like peptide 2
, GLP-2 receptor
, G protein-coupled receptor GLP2R
, glucagon-like peptide-2 receptor