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Data suggest that expression of GPR39 undergoes Rho kinase (show ROCK1 Proteins)-dependent desensitization following activation by zinc.
This study demonstrated that zinc upregulates PKCzeta (show PRKCZ Proteins) by activating GPR39 to enhance the abundance of ZO-1 (show TJP1 Proteins), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
obestatin/GPR39 system in the pathogenesis and/or clinical outcome of human gastric adenocarcinomas and highlight the potential usefulness of GPR39 as a prognostic marker in gastric cancer.
Chronic administration of many antidepressants induces GPR39 up-regulation, which suggests that the Zn(2+)-sensing receptor may be considered as a new target for drug development in the field of depression.
Taken together, our results provided a novel regulatory mechanism for GPR39-1b in NTRS1 signaling.
ZnR/GPR39-dependent expression of tight junctional proteins, thereby leading to formation of a sealed intestinal epithelial barrier.
Data suggests alterations (down-regulation) of the GPR39 receptor and involvement of CREB (show CREB1 Proteins)-BDNF (show BDNF Proteins) pathway, possibly triggered by GPR39, as a new pathomechanism of depression
Zn(2+) -dependent activation of ZnR/GPR39 also enhances the expression of the Ca(2+) -binding protein (show PVALB Proteins) S100A4 (show S100A4 Proteins) that is linked to invasion of prostate cancer cells.
GPR39 was present in thyroid autoimmune disease, non-toxic nodular goiter and toxic nodular goiter at band p51(kDa).
ZnR/GPR39 is tuned to sense physiologically relevant changes in extracellular pH that regulate ZnR-dependent signaling and ion transport activity
The zinc sensing receptor, ZnR/GPR39, triggers intracellular Ca(2 (show CA2 Proteins)+) signalling in colonocytes thereby inducing occludin (show OCLN Proteins) expression. Moreover, ZnR/GPR39 is essential for epithelial barrier recovery in the dextran sodium sulfate (DSS (show PMP22 Proteins)) ulcerative colitis model.
This study used mice expressing a Gpr39 promoter-driven LacZ (show GLB1 Proteins) reporter system to detect Gpr39 expression in the reproductive system at different phases of the estrous cycle and found an interesting region-specific distribution of Gpr39 in the mouse oviduct epithelium, which was associated with zinc metabolism.
This study has demonstrated the presence of GPR39 and the insulinotropic actions of trace metals on BRIN-BD11 (show DEFB110 Proteins) cells and pancreatic beta cells
The resukts of this study suggested that mZnR/GPR39-dependent upregulation of KCC2 (show SLC12A5 Proteins) activity provides homeostatic adaptation to an excitotoxic stimulus by increasing inhibition.
The results indicate depressive-like behavior in GPR39 Knockout mice with an immune response similar to that observed in depressive disorder.
The results of this study indicated that neurons, mZnR/GPR39 activity and subsequent Zn2+-dependent Ca2+ rises, ERK1/2 phosphorylation and up-regulation of NHE activity are all abolished at acidic pHe.
Results indicate a possible role of the GPR39 receptor in monoaminergic and glutamatergic neurotransmission, which plays an important role in the pathophysiology of depression
GPR39 contributed positively to skin wound healing: its loss led to a delay in wound healing during the intermediate stage.
The results of this study indicate the involvement of the GPR39 Zn(2+)-sensing receptor in the pathophysiology of depression with component of anxiety.
It indicated that GPR39 was a transducer of Zn(2+), and enhanced proliferation and differentiation of porcine intramuscular preadipocytes through activation of the PI3K/Akt (show AKT1 Proteins) signaling pathway.
Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).
G-protein coupled receptor 39
, G protein-coupled receptor 39
, G-protein coupled receptor 39-1
, G-protein coupled receptor 39-like
, orphan G-protein coupled receptor 39