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The first time that the haplotypes A33-DR3 and A33-DR9 were found with an enhanced predisposition to type 1 diabetes in Han Chinese.
HLA-DRB3 affects type 1 diabetes risk and islet autoantibodies.
this mouse model unravels a critical role for HLA-DR3 (show TNFRSF25 Proteins) in generating an autoimmune response to SmD and lupus nephritis in the NZM2328 background.
Haplotyping was done on 91 Southern Europe celiac patients. HLA-DR3 (show TNFRSF25 Proteins)-DQ2 (show TOR1A Proteins) without HLA-DR7-DQ2 (show TOR1A Proteins) was present in 62.6%, HLA-DR7-DQ2 (show TOR1A Proteins) without HLA-DR3 (show TNFRSF25 Proteins)-DQ2 (show TOR1A Proteins) was present in 16.5% and HLA-DR4 (show HLADRB4 Proteins)-DQ8 without HLA-DQ2 (show TOR1A Proteins) was present in 3.3%.
Children with the HLA haplotype DR3 (show TNFRSF25 Proteins)-DQ2 (show TOR1A Proteins), especially homozygotes, were found to be at high risk for celiac disease autoimmunity and celiac disease early in childhood.
The unusual DRB1*08:01 haplotype carrying DRB3*02:02 has been confirmed in a Dutch family.
HLA-DRB3*02:02 on the DRB1*03:01 haplotype can contribute to type 1 diabetes risk.
Prospective evaluation of matching for HLA-DRB3/4/5, -DQ, and -DP loci is warranted to reduce posttransplant risks in donor-recipient pairs matched for 7/8 HEL.
Three sets of HLA-DR3 (show TNFRSF25 Proteins)-positive haplotypes are designed that provide maximum risk of type 1 diabetes development in Indians and suggest a common Caucasian ancestor from which multiple haplotypes evolve independently.
Heterozygosity of HLA-DRB3*01:01 and HLA-DRB4 (show HLADRB4 Proteins)*01:01 as a potential predictor of fetal neonatal alloimmune thrombocytopenia.
HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
, HLA class II histocompatibility antigen, DR beta 3 chain
, HLA class II histocompatibility antigen, DRB1-7 beta chain
, MHC class II HLA-DR beta 3 chain
, MHC class II antigen DR beta 3 chain
, MHC class II antigen DRB3
, human leucocyte antigen DRB3