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Results describe the expression pattern of Xenopus islet-1 (Xisl-1) in the context of cardiovascular development.
Knock-down of Xisl-1 by specific morpholino leads to severe developmental defects, including eye and heart failure.
results identify Isl1 as a crucial transcription factor that plays essential roles in the gene regulatory program directing development of multiple arcuate neuronal subpopulations.
ISL-1 is widely expressed in Olfactory neuroblastoma (show ARHGEF16 Proteins) tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis
Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway showed increased gene expression of ISL1, OCT4 (show POU5F1 Proteins), KDR (show KDR Proteins) and NKX2.5 (show NKX2-5 Proteins).
In bladder exstrophy there is a clear correlation with the a mutation of the chromosome 5 ISL1 (5q11.1) gene.
SSBP3 (show SSBP3 Proteins) Interacts With Islet-1 and Ldb1 (show LDB1 Proteins) to Impact Pancreatic beta-Cell Target Genes
Concurrent ISL1/HOXA9 (show HOXA9 Proteins) methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality
Isl1 overexpression in embryonic stem cells results in normal electrophysiologically functioning cells.
The present study identified the first genome-wide significant locus for classic bladder exstrophy at chromosomal region 5q11.1, and provides strong evidence for the hypothesis that ISL1 is the responsible candidate gene in this region.
Suggest that ISL-1 may be a useful prognostic biomarker and may represent a novel therapeutic target for gastric adenocarcinoma.
Tcf7l2 (show TCF7L2 Proteins) is regulating proinsulin (show INS Proteins) expression directly via Isl1, Ins1 (show FOXM1 Proteins) and indirectly via MafA (show KLRG1 Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).
PDX1 (show PDX1 Proteins) and ISL1 regulation of insulin (show INS Proteins) gene expression in pancreatic beta cells, was investigated.
Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1/Lhx3 (show LHX3 Proteins) in nascent motor neurons and Isl1/Onecut1 (show ONECUT1 Proteins) in maturing hypaxial motor neurons.
These data reveal functional roles for an ISLET1-dependent network integrating beta-catenin (show CTNNB1 Proteins)/SHH (show SHH Proteins) signals in mesenchymal cell survival and outgrowth of the mandible during development.
ISL1 and JMJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac differentiation.
Pax2 (show PAX2 Proteins)-regulated ISL1 overexpression increases the embryonic ISL1(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos.
These results show that ISL1 is necessary for maximal thyrotrope response to hypothyroidism, in addition to its role in development of Rathke's pouch.
the Isl1/Ldb1 (show LDB1 Proteins) complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
All E1 sequences from lamprey to mouse responded equally well to Phox2a (show PHOX2A Proteins) and the Isl1-Lhx3 (show LHX3 Proteins) complex. Conversely, E2, the enhancer for limb-innervating motor neurons, was only found in tetrapod animals
Isl1 alternative splicing varies across different retinal cell types. Two isoforms of Isl1 differ functionally as transcriptional activators.
Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.
Ajuba plays a central role in regulating the second heart field during heart development by linking retinoic acid signaling to the function of Isl1, a key transcription factor in cardiac progenitor cells.
Isl1 is required for the selective outgrowth of the peripheral axons of Rohon-beard neurons.
prdm1a (show PRDM1 Proteins) Regulates sox10 (show SOX10 Proteins) and islet1 in the development of neural crest and Rohon-Beard sensory neurons.
By direct comparison of the upstream flanking regions of the zebrafish and human isl1 genes, we identified another highly conserved noncoding element.
primary motoneuron subtypes are likely to be specified by factors that act in parallel to or upstream of islet1 and islet2
Nkx6 proteins regulate MiP motorneuron development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
, ISL1 transcription factor, LIM/homeodomain, (islet-1)
, domesticus (clone 1.7 kB) islet-1
, insulin gene enhancer protein ISL-1
, ISL1 transcription factor, LIM/homeodomain
, ISL1 transcription factor LIM/homeodomain (islet-1)
, ISL1 transcription factor, LIM/homeodomain 1
, isl-1 homeobox
, Insulin gene enhancer protein ISL-1
, Islet 1
, Lim-homeodomain protein Islet1
, insulin related protein
, insulin gene enhancer protein isl-1