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Data suggest NNAT as a potential tumor suppressor in myxoid liposarcomas.
Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.
indicate that Nnat is related to keratinocyte differentiation by up-regulating involucrin (show IVL Proteins) expression
methylation status of a not-yet-described regulatory element within the NNAT locus that contains four potential CTCF (show CTCF Proteins) binding sites determines the expression level of NNAT
Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease
Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival.
A stringent analysis identified NNAT as a key imprinted gene that was dysregulated in induced pluripotent stem cells.
malin (show NHLRC1 Proteins) negatively regulates neuronatin and its loss of function in Lafora disease results in increased accumulation of neuronatin
A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nuc (show LEP Proteins)leotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity
Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia
The expression pattern suggests that Nnat may play an important role during eye development and in the maintenance of mature eye.
Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction.
Neuronatin appears to be a novel regulator of browning and metabolic substrate disposal in white adipocytes.
the Neuronatin locus employs the most basic mechanism for establishing allele-specific gene expression
Data show that Nnat initiates neural induction in ESCs through increasing intracellular Ca(2+) ([Ca(2+) ](i)) by antagonizing Ca(2+) -ATPase isoform 2 (sarco/endoplasmic reticulum Ca(2+) -ATPase isoform 2) in the endoplasmic reticulum.
Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin (show LEP Proteins) signaling and during fasting conditions
In the present study, we identified Nnat as a target gene of BETA2 in the pancreas.
Western blot analysis of the mouse brain showed reduced levels of calpastatin and rabaptin-5 and higher amount of neuronatin in PKU compared to the wild type.
Nnatalpha and Nnatbeta were primarily localized in the endoplasmic reticulum (ER), and their expressions increased insulin (show INS Proteins) secretion by increasing intracellular calcium levels.
Findings demonstrated important roles of NNAT in placenta function.
Cloning and sequencing of cDNA from porcine anterior pituitary cDNA library, encoding alpha- and beta-neuronatin, cloned as gene expressed by fetal developing brain. Relative amounts of alpha to beta type reversed just after birth.
polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 (show DIRAS3 Proteins) genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids
The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of the BLCAP gene, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. Two transcript variants encoding two different isoforms have been found for this gene.
, neuronatin alpha
, neuronatin isoform alpha