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TAR DNA Binding Protein ELISA Kits (TARDBP)
On www.antibodies-online.com are 31 TAR DNA Binding Protein (TARDBP) ELISA Kits from 11 different suppliers available. Additionally we are shipping TAR DNA Binding Protein Antibodies (234) and TAR DNA Binding Protein Proteins (14) and many more products for this protein. A total of 294 TAR DNA Binding Protein products are currently listed.
Synonyms:
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
list all ELISA KIts Gene Name GeneID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
TARDBP 298648  

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More ELISA Kits for TAR DNA Binding Protein Interaction Partners

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data suggest that stably folded N-terminal domain (NTD) is essential for correct TDP-43 function; point mutations in TDP-43 NTD that result in amyotrophic lateral sclerosis or frontotemporal lobar degeneration also destabilize TDP-43, disrupt RNA splicing, alter dimerization/localization of TDP-43 in cells, and cause pathological TDP-43 aggregates inside cells; leucine-27 is key residue for TDP-43 NTD dimerization.

  2. Motor-neuron disease (MND (show CLN8 ELISA Kits))-linked RNA-binding proteins (RBPs), TDP-43, FUS (show FUS ELISA Kits), and hnRNPA2B1 (show HNRNPA2B1 ELISA Kits), bind to and induce structural alteration of UGGAAexp. These RBPs suppress UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp folding and regulation of pentapeptide repeat translation.

  3. We directly link TDP-43 loss of function toxicity to two genes with rare amyotrophic lateral sclerosis and frontotemporal lobar degeneration-causing mutations, CHMP2B (show CHMP2B ELISA Kits) and ErbB4 (show ERBB4 ELISA Kits).

  4. We report that overexpression of HSPB8 (show HSPB8 ELISA Kits) in immortalized motor neurones decreased the accumulation of TDP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 was observed for HSPB8 (show HSPB8 ELISA Kits) in Drosophila melanogaster Overexpression of HSP67Bc, the functional ortholog of human HSPB8 (show HSPB8 ELISA Kits), suppressed the eye degeneration caused by the cytoplasmic accumulation of a TDP-43 variant

  5. The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo. Study provides further evidence confirming the critical role of the extreme N-terminus of TDP-43 in regulating protein structure as well as mediating toxicity associated with its aggregation.

  6. This animal disease model of TDP-43 Proteinopathy mice in which mutant human TDP-43 expression causes progressive neuron loss. Also show that these rNLS8 mice have a pattern of axonal dieback and cell death that mirrors that often observed in human patients.

  7. we analyzed fast axonal transport in larval motor neurons of Drosophila models of TARDBP (TDP-43), FUS (show FUS ELISA Kits) and C9orf72. We also analyzed the effect of loss-of-function mutants of the Drosophila orthologs of TDP-43 and FUS (show FUS ELISA Kits), TBPH and caz, respectively. The motor activities of larvae and adults in these models were assessed to correlate potential defects in axonal transport with locomotor deficits

  8. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  9. Mutant C9ORF72 impairs mitochondria activity in a different and opposite manner compared to mutant TDP-43. TARDBP and C9ORF72 mutations might trigger cell death by impairing not only RNA metabolism, but also mitochondria activity in ALS (show IGFALS ELISA Kits)/FTD (show FTL ELISA Kits) neurons since their mitochondrial energetic metabolism depends mainly on oxidative phosphorylation.

  10. 14-3-3 eta (show YWHAH ELISA Kits) isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. we found a significant overlap in genes that undergo both RBM17 (show RBM17 ELISA Kits)- and TDP-43-dependent cryptic splicing repression, many of which are associated with survival. We propose that repression of cryptic splicing by RBPs is critical for neuronal health and survival

  2. These results establish that SMN overexpression in motor neurons slows disease onset and outcome by ameliorating pathological signs in this model of mutant TDP-43-mediated amyotrophic lateral sclerosis (ALS).

  3. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  4. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  5. demonstrated that the levels of HSF1 (show HSF1 ELISA Kits) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  6. The present study identified USP7 (show USP7 ELISA Kits) and TDP-43 as the regulators of CRY1 (show CRY1 ELISA Kits) and CRY2 (show CRY2 ELISA Kits), underscoring the significance of the stability control process of CRY (show CRY2 ELISA Kits) proteins for period determination in the mammalian circadian clockwork.

  7. TDP-43 functions within a network of hnRNP (show HNRNPH2 ELISA Kits) proteins to inhibit the production of a truncated human SORT1 (show SORT1 ELISA Kits) receptor.

  8. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  9. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  10. UBQLN2 (show UBQLN2 ELISA Kits) dysregulation in neurons can drive NF-kappaB (show NFKB1 ELISA Kits) activation and cytosolic TDP-43 aggregation.

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (show CNBP ELISA Kits) tardbp and RNA binding protein fus (show FUS ELISA Kits).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (show FUS ELISA Kits) act in a pathogenic pathway that is independent of SOD1 (show SOD1 ELISA Kits).

TAR DNA Binding Protein (TARDBP) Antigen Profile

Antigen Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) Elisa Kit
  • Tardbp protein (tardbp) Elisa Kit
  • TAR DNA binding protein (tardbp) Elisa Kit
  • TAR DNA binding protein (Tardbp) Elisa Kit
  • TAR DNA-binding protein 43-like (LOC100621383) Elisa Kit
  • 1190002A23Rik Elisa Kit
  • ALS10 Elisa Kit
  • C85084 Elisa Kit
  • DKFZp459I2127 Elisa Kit
  • tardbp Elisa Kit
  • TDP-43 Elisa Kit
  • Tdp43 Elisa Kit
  • wu:fb77f02 Elisa Kit
  • wu:fc52g10 Elisa Kit

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPECIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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