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These results posit GALNT2 as a direct modulator of high density lipoprotein metabolism across mammals.
These data suggest that the region responsible for the Mvwf1 regulatory switch lies within an approximately 30-kb genomic interval upstream of the B4galnt2 (show B4GALNT2 Proteins) gene.
The crystal structure of GalNAc-T2 with the galactose derivative traps the enzyme in an inactive form; this suggests that compounds only containing the beta-phosphate could be efficient ligands for the enzyme. Computational studies with GalNAc-T2 corroborate these findings and provide further insights into the mechanism of the catalytic cycle of this family of enzymes.
Our data suggest a role of GALNT2 expression changes on serum triglycerides.
This study demonstrates that the polypeptide GalNAc-transferase 2 (GalNAc-T2) specifically O-glycosylates beta 1-adrenergic receptor (show ADRB1 Proteins) at five residues in the extracellular N terminus, including the Ser (show SIGLEC1 Proteins)-49 residue at the location of the common S49G single-nucleotide polymorphism.
The presence of lectin domain T3lec or T4lec during ppGalNAc-T2 and ppGalNAc-T3 catalytic reaction had a clear inhibitory effect on GalNAc-T (show B4GALNT1 Proteins) activity.
Possible inter-locus interactions among the DOCK7, PCSK9 (show PCSK9 Proteins) and GALNT2 SNPs were also noted.
Differences in lipid profiles between the Jing and Han populations might partially attribute to the DOCK7, PCSK9 (show PCSK9 Proteins) and GALNT2 gene polymorphisms and their haplotypes determining different risk for the development of cardiovascular diseases.
The results suggest that rs4846913 and rs2144300 drive the association to HDL (show HSD11B1 Proteins)-C plasma levels through an inhibitory regulation of GALNT2.
The present work indicates that SNP rs4846914 in GALNT2 gene is related to an increased risk of hypertension in China Han population, but the APOE (show APOE Proteins) gene is not.
Multiple hepatic regulatory variants at the GALNT2 GWAS locus have been found associated with high-density lipoprotein cholesterol.
This gene encodes polypeptide N-acetylgalactosaminyltransferase 2, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases.
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2
, polypeptide GalNAc transferase 2
, polypeptide N-acetylgalactosaminyltransferase 2
, pp-GaNTase 2
, protein-UDP acetylgalactosaminyltransferase 2
, UDP-GalNAc transferase 2