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IPO11-HTR1A (show HTR1A Proteins) is a significant risk gene region for attention deficit hyperactivity disorder in Caucasians.
Data indicate that ubiquitin-conjugating enzyme (show Ube2t Proteins) UBE2E3 (show UBE2E3 Proteins) and importin 11 (Imp (show IMPA1 Proteins)-11)promote the nuclear accumulation and activity of transcription factor NF-E2 (show NFE2 Proteins) (Nrf2 (show GABPA Proteins)) by restricting the transcription factor from partitioning to the mitochondria
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1\; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000
, Ran binding protein 11
, ran-binding protein 11