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CFL1 (show VPS72 Proteins) itself does not translocate actin into the cell nucleus but this transport requires the functional expression of IPO9.
IPO9 associates with 2 stable stem-loop structures of the IFN-epsilon (show IFNE Proteins) 5'UTR. IPO9 overexpression decreased, and IPO9 silencing increased basal IFN-epsilon (show IFNE Proteins) expression.
specific interaction between a member of the importin beta (show KPNB1 Proteins)/karyopherin beta superfamily, importin 9, and the A subunit of PP2A (PR65)
the active maintenance of nuclear actin levels by importin 9 is required for maximal transcriptional activity
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.
, importin 9
, ran-binding protein 9
, Ran binding protein 9