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These results suggest that the Japanese encephalitis virus NS5 inhibits the induction of type I interferon by targeting KPNA3 and KPNA4.
Our results showed that miR (show MLXIP Proteins)-181 family expression was closely correlated with TCGA subtypes and patients' overall survival, indicating that miR (show MLXIP Proteins)-181b.
Karyopherin alpha 3 (show KPNA3 Proteins) and karyopherin alpha 4 proteins mediate the nuclear import of methyl-CpG binding protein 2 (show MBD2 Proteins).
miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy
upon DNA damage transport adaptor importin-alpha4 imports XPA into the nucleus in an ATR-dependent manner.
Importin alpha3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function.
Impalpha3 is an HIV integrase-interacting cofactor and is required for efficient HIV-1 nuclear import and replication.
stress-induced accumulation of non-ubiquitinated p53 in the cytoplasm promotes interaction with importin-alpha3 and rapid import
Expression of importin alpha3, a protein involved in p50 (show CD40 Proteins)/p65 (show GORASP1 Proteins) nuclear import, was decreased in cells overexpressing PHB.
The present study suggests that the KPNA3 (show KPNA3 Proteins) may contribute genetically to schizophrenia in a small effect size.
MOS6, identified by positional cloning, encodes importin alpha3, one of eight alpha importins in Arabidopsis [MOS6]
Expression of DnaJ-1 (show DNAJB1 Proteins) potently suppresses alpha1ACT-dependent degeneration , concomitant with decreased aggregation of the pathogenic protein. Mutating the nuclear importer karyopherin a3 also leads to reduced toxicity from pathogenic CACNA1A (show CACNA1A Proteins)
These results reveal that the nuclear transport of Notch (show NOTCH1 Proteins) intracellular domain (Notch (show NOTCH1 Proteins)-ICD)is mediated by the canonical Importin-alpha3/Importin-beta (show KPNB1 Proteins) transport pathway.
each Imp (show BRAP Proteins)-alpha protein carries during Drosophila spermatogenesis distinct, albeit overlapping, functions that may involve nuclear import of proteins, microtubule organisation, and other yet unknown processes
Data show that Drosophila Naked cuticle (Nkd (show NKD1 Proteins)) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt (show WNT4 Proteins)/beta-catenin signaling.
Loss of importin alpha 4 is associated with oxidative stress.
IMPalpha4 overexpression induced a significant decrease in Oct3/4 (show POU5F1 Proteins) protein levels compared to control transfections. IMPalpha4 protein showed a unique and striking shift in subcellular localization from the nucleus to the cytoplasm during differentiation.
Expression of importin alpha3, a protein involved in p50 (show LSP1 Proteins)/p65 (show NFkBP65 Proteins) nuclear import, was decreased in colonic mucosa cells of transgenic mice overexpressing human prohibitin (show PHB Proteins).
In postnatal testes, importin alpha3 and alpha4 in spermatocytes, spermatids, and Sertoli cells display cytoplasmic and nuclear localization, respectively.
These results suggest that the bovine adenovirus-3 52K protein contains a bipartite nuclear localization signal, which preferentially utilize an importin alpha3 nuclear import receptor-mediated pathway to transport the 52K protein to the nucleus.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import.
importin alpha Q1
, importin subunit alpha-3
, importin subunit alpha-4
, karyopherin subunit alpha-4
, importin alpha 4
, importin alpha Q2
, importin alpha-3
, karyopherin subunit alpha-3
, importin a3
, importin alpha
, importin alpha3
, karyopherin a3
, karyopherin alpha4
, importin alpha 3
, karyopherin alpha 4 (importin alpha 3)
, karyopherin (importin) alpha 4
, predicted role in nuclear import