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Data shows that Importin 7 (show IPO7 Proteins) binds many partners from ovary that alpha are involved in RNA processing, chromosome organization, and chromatin modification.
Importin alpha7 is a new member of the small group of maternal effect genes.
Overexpression of Kpna6 (show KPNA6 Proteins) facilitates Keap1 (show KEAP1 Proteins) nuclear import and attenuates Nrf2 (show NFE2L2 Proteins) signaling, whereas knockdown of Kpna6 (show KPNA6 Proteins) slows down Keap1 (show KEAP1 Proteins) nuclear import and enhances the Nrf2 (show NFE2L2 Proteins)-mediated adaptive response induced by oxidative stress.
BIG3 (show WDR5 Proteins) may block the KPNAs (KPNA1 (show KPNA1 Proteins), KPNA5, and KPNA6 (show KPNA6 Proteins)) binding region(s) of PHB2 (show PHB2 Proteins).
eVP24 recognizes a unique nonclassical nuclear localization signal binding site on KPNA5 that is necessary for efficient phosphoryated STAT1 (show STAT1 Proteins) nuclear transport.
Study identified the sequences KKKRR, KKKRK, and KKRKK as the optimal sequences for binding to this site for mouse importin-alpha2, human importin-alpha1, and human importin-alpha5, respectively.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion\; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.
, importin subunit alpha-7
, karyopherin (importin) alpha 5
, karyopherin subunit alpha-6
, importin subunit alpha-6
, karyopherin subunit alpha-5
, importin alpha 6