ADIPOQ Protein (AA 18-247, full length) (His tag)

Catalog No. ABIN1046473

Product Details

Target: ADIPOQ (Adiponectin (ADIPOQ))

Protein Type: Recombinant

Protein Characteristics: AA 18-247, full length

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This ADIPOQ protein is labelled with His tag.

Application: Western Blotting (WB), ELISA, Particle-Enhanced Turbidimetric Assay (PETIA)

Sequence: EDDVTTTEEL APALVPPPKG TCAGWMAGIP GHPGHNGTPG RDGRDGTPGE KGEKGDAGLL GPKGETGDVG MTGAEGPRGF PGTPGRKGEP GEAAYVYRSA FSVGLETRVT VPNVPIRFTK IFYNQQNHYD GSTGKFYCNI PGLYYFSYHI TVYMKDVKVS LFKKDKAVLF TYDQYQEKNV DQASGSVLLH LEVGDQVWLQ VYGDGDHNGL YADNVNDSTF TGFLLYHDTN

Characteristics: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Purity: 95 %

Application Details

Comment:

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 20mM Tris-Hcl, 0.5M NaCl, 10% glycerin, PH 8.0, 200 mM Imidazole

Storage: -20 °C

References

Wang, Xu, Knight, Xu, Cooper: "Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity." in: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19521-9, (2002) (PubMed).

Yamauchi, Kamon, Waki, Terauchi, Kubota, Hara, Mori, Ide, Murakami, Tsuboyama-Kasaoka, Ezaki, Akanuma, Gavrilova, Vinson, Reitman, Kagechika, Shudo, Yoda, Nakano, Tobe, Nagai, Kimura, Tomita, Froguel et al.: "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. ..." in: Nature medicine, Vol. 7, Issue 8, pp. 941-6, (2001) (PubMed).

Target Details

Target: ADIPOQ (Adiponectin (ADIPOQ))

Alternative Name: Adiponectin (ADIPOQ Products)

Background: Synonyms: 30 kDa adipocyte complement-related protein,Adipocyte complement-related 30 kDa protein,ACRP30,Adipocyte, C1q and collagen domain-containing protein,Adipocyte-specific protein AdipoQ

Molecular Weight: 29 kD

UniProt: Q60994