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ATPase, H+/K+ Exchanging, alpha Polypeptide Proteins (ATP4A)
On www.antibodies-online.com are 11 ATPase, H+/K+ Exchanging, alpha Polypeptide (ATP4A) Proteins from 4 different suppliers available. Additionally we are shipping ATP4A Antibodies (14) and ATP4A Kits (8) and many more products for this protein. A total of 34 ATP4A products are currently listed.
Synonyms:
ATP6A, Hka, Hkatpc
list all proteins Gene Name GeneID UniProt
ATP4A 495 P20648
Rat ATP4A ATP4A 24216  
ATP4A 11944  

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ATP4A Proteins (ATP4A) by Origin

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More Proteins for ATP4A Interaction Partners

Human ATPase, H+/K+ Exchanging, alpha Polypeptide (ATP4A) interaction partners

  1. In conclusion, patients homozygous for an inactivating ATP4A mutation develop gastric ECL (show CCL21 Proteins)-cell carcinoids in their 3rd or 4th decade.

  2. Homozygous missense mutation in the 14th exon of the ATP4A gene (c.2107C>T) is responsible for an atypical familial type I gastric neuroendocrine tumour.

  3. ATP4A are found in nearly one-third of children with type 1 diabetes and more common among females. In this cross-sectional analysis, Hp infection was not associated with autoimmunity against parietal cells.

  4. Downregulation of ATP4A gene is associated with gastric cancer.

  5. Gastric H+/K+-ATPase (show ATP4b Proteins) activities are not associated with H pylori status in patients with chronic gastritis.

  6. study concludes that IL-1beta (show IL1B Proteins) upregulates HKalpha transcription by inducing Sp1 (show PSG1 Proteins) binding to HKalpha Sp1 (show PSG1 Proteins) & NF-kappaB (show NFKB1 Proteins) sites & that Helicobacter pylori perturbation of HKalpha expression is independent of Sp1 (show PSG1 Proteins)-mediated basal HKalpha transcription

  7. cigarette smoke extract may cause an increase in the amount and activity of H,K-ATPase (show ATP1A1 Proteins) and smokers' susceptibility to development of peptic ulcer

Pig (Porcine) ATPase, H+/K+ Exchanging, alpha Polypeptide (ATP4A) interaction partners

  1. New cryo-electron microscopic structures of H+,K+-ATPase (show ATP1A1 Proteins) using a phosphate analog and a specific antagonist, SCH28080.

  2. for the Na(+)/K(+)-ATPase (show ATP1A1 Proteins), Mg(2 (show MCOLN1 Proteins)+)-vanadate is unable to recruit all the Rb(+)-bound to the Rb(+)-occluded form of the Rb(+)-vanadate-H(+)/K(+)-ATPase (show ATP4b Proteins) complex

  3. Results provide strong evidence that the catalytic unit of octaethylene glycol dodecyl ether-solubilized gastric H/K-ATPase (show ATP4b Proteins) is (show ATP11A Proteins) a tetraprotomer.

  4. Data describe the functional characteristics of the oligomeric form of the membrane-bound gastric H,K-ATPase (show ATP1A1 Proteins).

  5. The number of parietal cells explained part of the differences in the expression of the H(+)/K(+)-ATPase (show ATP4b Proteins) gene.

  6. structural rearrangements in the H+,K+-ATPase are much smaller than those observed in the related SERCA ATPase

Xenopus laevis ATPase, H+/K+ Exchanging, alpha Polypeptide (ATP4A) interaction partners

  1. The ATP4/Wnt module activated foxj1 downstream of ciliated cell fate specification. In multiciliated cells of the epidermis, ATP4a was also necessary for normal myb expression, apical actin formation, basal body docking and alignment of basal bodies.

  2. ATP4a is required for Wnt (show WNT2 Proteins)-dependent Foxj1 (show FOXJ1 Proteins) expression and leftward flow in Xenopus left-right development.

Mouse (Murine) ATPase, H+/K+ Exchanging, alpha Polypeptide (ATP4A) interaction partners

  1. ENaC (show SCNN1A Proteins) activity in the cortical collecting duct of HKalpha1 H(+),K(+)-ATPase (show ATP1A1 Proteins) knockout mice is uncoupled from Na(+) intake.

  2. Point mutation in Atp4a (or Atp4a-/- knockout) results in achlorhydria and leads to iron-deficiency anemia; thus, functioning Atp4a is necessary for absorption of dietary iron leading to effective erythropoiesis.

  3. The metabolism of H,K-ATPases in in collecting ducts of normal and potassium-depleted mice reflect the functional expression of gastric and colonic H,K-ATPase (show ATP1A1 Proteins), respectively.

  4. Prevention of autoimmune gastritis requires the extra-thymic purging of highly autoaggressive H(+)/K(+) ATPase (show ATP4b Proteins)-specific T cells to produce a T-cell repertoire that is more susceptible to the suppressive activity of regulatory T cells.

ATP4A Protein Profile

Protein Summary

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase.

Alternative names and synonyms associated with ATP4A

  • ATPase, H+/K+ exchanging, alpha polypeptide (ATP4A)
  • ATPase, H+/K+ exchanging, alpha polypeptide (Atp4a)
  • ATPase, H+/K+ exchanging, alpha polypeptide (atp4a)
  • ATPase, H+/K+ exchanging, gastric, alpha polypeptide (Atp4a)
  • ATP6A protein
  • Hka protein
  • Hkatpc protein

Protein level used designations for ATP4A

ATPase, H+/K+ transporting, alpha polypeptide , H(+)-K(+)-ATPase alpha subunit , gastric H(+)/K(+) ATPase subunit alpha , gastric H+/K+ ATPase alpha subunit , gastric H,K-ATPase alpha subunit , gastric H,K-ATPase catalytic subunit , gastric hydrogen-potassium ATPase , potassium-transporting ATPase alpha chain 1 , proton pump , hydrogen/potassium-exchanging ATPase 4A , H /K exchanging ATPase alpha , H+/K+ exchanging ATPase alpha polypeptide , (H+ + K+)-ATPase , adenosinetriphosphatase , alpha H-K , gastric H(+)-K(+)-ATPase alpha-subunit , ATPase, H+/K+ exchanging, alpha polypeptide , H+/K+-ATPase alpha , H+K+-transporting alpha 1

GENE ID SPECIES
495 Homo sapiens
24216 Rattus norvegicus
431686 Canis lupus familiaris
397552 Sus scrofa
100009279 Oryctolagus cuniculus
399450 Xenopus laevis
11944 Mus musculus
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