HSV ICP4 antibody (N-Term)

Catalog No. ABIN966334

This Rabbit Polyclonal antibody specifically detects HSV ICP4 in IHC. It exhibits reactivity toward Herpes Simplex Virus (HSV)and has been mentioned in 1 publication.

Quick Overview for HSV ICP4 antibody (N-Term) (ABIN966334)

Target: HSV ICP4 (Herpes Simplex Virus ICP4 (HSV ICP4))

Reactivity: Herpes Simplex Virus (HSV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSV ICP4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-HSV ICP4 Antibody

Binding Specificity: N-Term

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of Human herpesvirus 2 ICP4 (Trans-acting transcriptional protein ICP4)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-HSV ICP4 antibody (ABIN966334)

Dolan, Jamieson, Cunningham, Barnett, McGeoch: "The genome sequence of herpes simplex virus type 2." in: Journal of virology, Vol. 72, Issue 3, pp. 2010-21, (1998) (PubMed).

Target Details for HSV ICP4

Target: HSV ICP4 (Herpes Simplex Virus ICP4 (HSV ICP4))

Target Type: Viral Protein

Background: ICP4 (Trans-acting transcriptional protein ICP4) is a transcriptional transactivator that binds with high affinity to the sequence 5'-ATCGTC-3'. ICP4 may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. ICP4 negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis. ICP4 is a homodimer and interacts with transcriptional regulator ICP27, this interaction is required for proper incorporation of ICP4 into virions. The long stretch of Ser is a major site of phosphorylation. Only the phosphorylated forms are capable of interacting with beta or gamma genes. ICP4 belongs to the herpesviridae ICP4/IE140/IE180 family.
Synonyms: IE175 (Infected cell protein 4, Transcriptional activator IE175, Alpha-4 protein)