Browse our Arachidonate 15-Lipoxygenase Proteins (ALOX15)

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Arachidonate 15-Lipoxygenase Proteins (ALOX15)
On are 7 Arachidonate 15-Lipoxygenase (ALOX15) Proteins from 5 different suppliers available. Additionally we are shipping Arachidonate 15-Lipoxygenase Antibodies (80) and Arachidonate 15-Lipoxygenase Kits (16) and many more products for this protein. A total of 109 Arachidonate 15-Lipoxygenase products are currently listed.
12-LO, 12-LOX, 15-LOX, 15-LOX-1, 15LOX-1, Alox12, Alox12l, ALOX15, L-12LO
list all proteins Gene Name GeneID UniProt
ALOX15 246 P16050
ALOX15 11687 P39654
Rat ALOX15 ALOX15 81639 Q02759

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Arachidonate 15-Lipoxygenase Proteins (ALOX15) by Origin

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More Proteins for Arachidonate 15-Lipoxygenase Interaction Partners

Pig (Porcine) Arachidonate 15-Lipoxygenase (ALOX15) interaction partners

  1. The crystal structure of a mammalian 12-lipoxygenase reveals a plausible substrate access channel for oxygen.

  2. 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.

  3. EPR (show EREG Proteins) spectroscopy and electrospray mass spectroscopy reveal distinctive features of the iron site in leukocyte arachidonate 12-lipoxygenase (show ALOX12 Proteins).

Human Arachidonate 15-Lipoxygenase (ALOX15) interaction partners

  1. we propose that increased ALOX15 expression in heart tissue under ischemic conditions may lead to increased production of 15-HETE, potentially contributing to thrombosis.

  2. the results of the present study indicated that the natural products, CA, quercetin and morin hydrate, offer potential as adjuvant therapeutic agents for SMinduced toxicity, not only by reducing inflammation mediated by the p38 (show CRK Proteins) and LOX (show LOX Proteins) signaling pathways, but also by decreasing the generation of ROS (show ROS1 Proteins) and nitrate/nitrite.

  3. 15-LOX-1 re-expression downregulates the expression of MTA1 (show MTA1 Proteins) in colorectal cancer cell lines.

  4. The molecular origin of substrate specificity of 15-LOX-1 for linoleic acid in comparison with arachidonic acid has been analyzed.

  5. Hypoxia increase the production of ROS (show ROS1 Proteins) through the 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid pathway.

  6. The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer

  7. variation in inflammation related genes ALOX15 and IL6 (show IL6 Proteins) was associated with bone microarchitecture and density in young adult women, but appears to be less important in the elderly

  8. Significant associations with NSAID-exacerbated respiratory disease were identified for: ALOX15 homozygous genotype and PTGS-1 (show PTGS1 Proteins) rs5789 A/A homozygous genotype

  9. limiting ALOX15 expression by AMPK (show PRKAA1 Proteins) may promote an anti-inflammatory phenotype of IL-4 (show IL4 Proteins)-stimulated human macrophages

  10. Effect of 12/15-LOX on colorectal tumorigenesis in mouse models could be affected by tumor cell type (human or mouse), relative 12/15 LOX activity in tumor cells and stroma as well as the relative tumor 13-HODE and 12-HETE levels.

Rabbit Arachidonate 15-Lipoxygenase (ALOX15) interaction partners

  1. Results indicate 15-lipoxygenase modified LDL as a new inducer for LOX-1 (show OLR1 Proteins) expression and as a new ligand for LOX-1 (show OLR1 Proteins).

Mouse (Murine) Arachidonate 15-Lipoxygenase (ALOX15) interaction partners

  1. data support that endothelial, rather than monocytic/macrophagic, 12/15-LO has a critical role in hyperglycemia-induced ICAM-1 (show ICAM1 Proteins) expression, leukocyte adhesion, and subsequent local retinal barrier dysfunction.

  2. This study determined that 1) deletion of 12/15-lipoxygenase (LOX) promotes the generation of epoxyeicosatrienoic acids, the cytochrome P-450-derived metabolites in postmyocardial infarction (post-MI) healing; 2) acute exposure of fatty acids to 12/15-LOX(-/-) mice drives leukocyte (neutrophils and macrophages) clearance post-MI; and 3) metabolic transformation of fats is the significant contributor in leukocyte clearance

  3. These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4 (show GPX4 Proteins)(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 (show GPX4 Proteins) deficiency.

  4. The 12/15-LOX plays an important role in the metabolism of eicosanoids in response to allergen-induced airway inflammation.

  5. 12/15-LO-derived oxidized lipids regulate histone modifications associated with profibrotic gene expression in MCs (show SMCP Proteins), and 12/15-LO can mediate similar actions of TGF-beta1 (show TGFB1 Proteins) and diabetes.

  6. In experimental postoperative ileus, 12/15-lipoxygenase was expressed, mainly in CX3CR1 (show CX3CR1 Proteins)(+)/Ly6C(+) infiltrating monocytes, not Ly6G(+) neutrophils. 12/15-LOX mediates ileus resolution by producing proresolving docosahexaenoic acid-derived protectin (show CD59 Proteins) DX.

  7. we show that oxidized phospholipids generated by 12/15-LOX can act as substrates for key proteins required for effective autophagy and that cells deficient in this enzyme show evidence of autophagic dysfunction

  8. SHH (show SHH Proteins)-responsive 5-lipoxygenase (show ALOX5 Proteins), 15-lipoxygenase and COX-2 modulate Dectin-1 (show CLEC7A Proteins)-induced inflammatory cytokines.

  9. Effect of 12/15-LOX on colorectal tumorigenesis in mouse models could be affected by tumor cell type (human or mouse), relative 12/15 LOX activity in tumor cells and stroma as well as the relative tumor 13-HODE and 12-HETE levels.

  10. These observations provide novel insights on the role of XO in 12/15-LO-induced JamA (show F11R Proteins) tyrosine phosphorylation and TJ disruption leading to increased vascular permeability in response to HFD.

Arachidonate 15-Lipoxygenase (ALOX15) Protein Profile

Protein Summary

demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity

Alternative names and synonyms associated with Arachidonate 15-Lipoxygenase (ALOX15)

  • arachidonate 15-lipoxygenase (ALOX15)
  • arachidonate 15-lipoxygenase (Nmul_A0532)
  • arachidonate 15-lipoxygenase (Sden_1680)
  • arachidonate 15-lipoxygenase (Swoo_2919)
  • Arachidonate 15-lipoxygenase (PCC8801_3106)
  • Arachidonate 15-lipoxygenase (Cyan8802_3014)
  • Arachidonate 15-lipoxygenase (Nwat_1315)
  • arachidonate 12-lipoxygenase (ALOX12)
  • arachidonate 15-lipoxygenase (Alox15)
  • 12-LO protein
  • 12-LOX protein
  • 15-LOX protein
  • 15-LOX-1 protein
  • 15LOX-1 protein
  • Alox12 protein
  • Alox12l protein
  • ALOX15 protein
  • L-12LO protein

Protein level used designations for ALOX15

arachidonate 15-lipoxygenase , Arachidonate 15-lipoxygenase , 12S-LOX , 12S-lipoxygenase , arachidonate 12-lipoxygenase, 12S-type , 15-LOX , 15-lipooxygenase-1 , arachidonate omega-6 lipoxygenase , 12-LOX , erythroid cell-specific 15-lipoxygenase , lipoxygenase , omega-6 lipoxygenase , arachidonate 12-lipoxygenase, leukocyte-type , 12/15-LOX

748294 Pan troglodytes
3784521 Nitrosospira multiformis ATCC 25196
4018156 Shewanella denitrificans OS217
6117234 Shewanella woodyi ATCC 51908
7102416 Cyanothece sp. PCC 8801
8392342 Cyanothece sp. PCC 8802
9392786 Nitrosococcus watsonii C-113
396971 Sus scrofa
246 Homo sapiens
489458 Canis lupus familiaris
282139 Bos taurus
100009114 Oryctolagus cuniculus
11687 Mus musculus
81639 Rattus norvegicus
100174413 Pongo abelii
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