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The crystal structure of a mammalian 12-lipoxygenase reveals a plausible substrate access channel for oxygen.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.
EPR (show EREG Proteins) spectroscopy and electrospray mass spectroscopy reveal distinctive features of the iron site in leukocyte arachidonate 12-lipoxygenase (show ALOX12 Proteins).
These results indicated that 15-LOX-1 is a potential target for inhibiting the trafficking of DCs to lymphoid organs and inflamed tissues and decreasing the inflammatory response attenuating symptoms of certain immunologic and inflammatory disorders such as dermatitis.
Kelavkar and Badr (1999) stated that the ALOX15 gene maps to 17p13.3 in close proximity to the tumor-suppressor gene TP53 (show TP53 Proteins) and stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis.
we propose that increased ALOX15 expression in heart tissue under ischemic conditions may lead to increased production of 15-HETE, potentially contributing to thrombosis.
the results of the present study indicated that the natural products, CA, quercetin and morin hydrate, offer potential as adjuvant therapeutic agents for SMinduced toxicity, not only by reducing inflammation mediated by the p38 (show CRK Proteins) and LOX (show LOX Proteins) signaling pathways, but also by decreasing the generation of ROS (show ROS1 Proteins) and nitrate/nitrite.
15-LOX-1 re-expression downregulates the expression of MTA1 (show MTA1 Proteins) in colorectal cancer cell lines.
The molecular origin of substrate specificity of 15-LOX-1 for linoleic acid in comparison with arachidonic acid has been analyzed.
Hypoxia increase the production of ROS (show ROS1 Proteins) through the 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid pathway.
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer
variation in inflammation related genes ALOX15 and IL6 (show IL6 Proteins) was associated with bone microarchitecture and density in young adult women, but appears to be less important in the elderly
Significant associations with NSAID-exacerbated respiratory disease were identified for: ALOX15 homozygous genotype and PTGS-1 (show PTGS1 Proteins) rs5789 A/A homozygous genotype
Results indicate 15-lipoxygenase modified LDL as a new inducer for LOX-1 (show OLR1 Proteins) expression and as a new ligand for LOX-1 (show OLR1 Proteins).
The present study investigated the roles of arachidonate 15-lipoxygenase (Alox15) in the clearance of dying adipocytes by adipose tissue macrophages.
data support that endothelial, rather than monocytic/macrophagic, 12/15-LO has a critical role in hyperglycemia-induced ICAM-1 (show ICAM1 Proteins) expression, leukocyte adhesion, and subsequent local retinal barrier dysfunction.
This study determined that 1) deletion of 12/15-lipoxygenase (LOX) promotes the generation of epoxyeicosatrienoic acids, the cytochrome P-450-derived metabolites in postmyocardial infarction (post-MI) healing; 2) acute exposure of fatty acids to 12/15-LOX(-/-) mice drives leukocyte (neutrophils and macrophages) clearance post-MI; and 3) metabolic transformation of fats is the significant contributor in leukocyte clearance
These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.
The 12/15-LOX plays an important role in the metabolism of eicosanoids in response to allergen-induced airway inflammation.
12/15-LO-derived oxidized lipids regulate histone modifications associated with profibrotic gene expression in MCs (show SMCP Proteins), and 12/15-LO can mediate similar actions of TGF-beta1 (show TGFB1 Proteins) and diabetes.
In experimental postoperative ileus, 12/15-lipoxygenase was expressed, mainly in CX3CR1 (show CX3CR1 Proteins)(+)/Ly6C(+) infiltrating monocytes, not Ly6G(+) neutrophils. 12/15-LOX mediates ileus resolution by producing proresolving docosahexaenoic acid-derived protectin (show CD59 Proteins) DX.
we show that oxidized phospholipids generated by 12/15-LOX can act as substrates for key proteins required for effective autophagy and that cells deficient in this enzyme show evidence of autophagic dysfunction
SHH (show SHH Proteins)-responsive 5-lipoxygenase (show ALOX5 Proteins), 15-lipoxygenase and COX-2 modulate Dectin-1 (show CLEC7A Proteins)-induced inflammatory cytokines.
Effect of 12/15-LOX on colorectal tumorigenesis in mouse models could be affected by tumor cell type (human or mouse), relative 12/15 LOX activity in tumor cells and stroma as well as the relative tumor 13-HODE and 12-HETE levels.
demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity
, Arachidonate 15-lipoxygenase
, arachidonate 12-lipoxygenase, 12S-type
, arachidonate omega-6 lipoxygenase
, erythroid cell-specific 15-lipoxygenase
, omega-6 lipoxygenase
, arachidonate 12-lipoxygenase, leukocyte-type