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Ccr7 functions during axis formation as a GPCR to inhibit beta-catenin (show CTNNB1 Proteins), likely by promoting Ca(2 (show CA2 Proteins)+) transients throughout the blastula.
Results demonstrated that the deletion of CCR7 significantly decreases levels of activated Notch1 (show NOTCH1 Proteins), and provide evidence that crosstalk between CCR7 and Notch1 (show NOTCH1 Proteins) promotes stemness in mammary cancer cells ultimately potentiating mammary tumor progression.
CCR7 deficiency lead to accumulation of CD8 (show CD8A Proteins)+ adipose tissue leukocytes, which was further exacerbated by HFD feeding.
in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11 (show MAPK11 Proteins)), located within the Ity8 interval, and representing a potential positional candidate gene
Taken together, these data suggest that CCR7 biases memory CD8 (show CD8A Proteins) T cells toward IL-7 (show IL7 Proteins)-dependent niches over IL-15 (show IL15 Proteins)-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology
CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mesenteric lymph nodes.
CCR7 overexpression and RelB (show RELB Proteins) knockdown (KD) in imDCs improve skin-graft survival in a murine skin-transplantation model. Transfection with Ad-CCR7 and RelB (show RELB Proteins) KD in imDCs may be an effective approach inducing immune tolerance, thus being potentially valuable for inhibiting allograft rejection.
data point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute West Nile virus infection
The results suggest that CCR7 plays a causal role in maintaining innate and adaptive immunity in obesity.
these data indicate that CCR7 and BTLA (show BTLA Proteins) cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA (show BTLA Proteins)-expressing counterparts that show a more immunocompetent or immunotolerant phenotype
Study shows that miR (show MLXIP Proteins)-1275 can positively regulate CCR7 expression in squamous cell carcinoma of head and neck (SCCHN) with different mechanisms.
Study provide evidence that CCR7 mediates EMT (show ITK Proteins) progress via AKT (show AKT1 Proteins) pathway, which indicates that CCR7 has a key role in breast cancer progression.
Report an increased percentage of peripheral CCR7 T cells accompanied by endothelial dysfunction in patients with ankylosing spondylitis.
The analysis of gene amplification and mRNA levels showed the expression of CCR7 in breast cancer correlated with better prognosis.
that CCR7 mediates TGF-beta1 (show TGFB1 Proteins)-induced MMP2 (show MMP2 Proteins)/9 expression through NF-kappaB (show NFKB1 Proteins) signaling
leukocyte subsets express distinct patterns of CCR7 sialylation that contribute to receptor signaling and fine-tuning chemotactic responses.
tumor microenvironment stimulation down-regulated the migration of CCR7-expressing tumor cells toward CCL21 (show CCL21 Proteins) and inhibited the formation of directional protrusions toward CCL21 (show CCL21 Proteins) in a novel 3-dimensional hydrogel system.
CCR7 expression levels in human tumors correlate with signatures of CD141 (show THBD Proteins)(+) DC, intratumoral T cells, and better clinical outcomes.
specific role for CCL21/CCR7 in promoting EMT and metastasis in CD133+ pancreatic cancer stem-like cells
This study showed that CCR7 are overexpressed in CD4 (show CD4 Proteins)(-) CD8 (show CD8A Proteins)(-) thymocytes of myasthenia gravis patients.
Fluorescent dye-labeled gammadelta T cells from afferent and efferent lymph lack CCR7 surface expression and display high levels of CD62L (show SELL Proteins) compared with CD4 (show CD4 Proteins) T cells, which do express CCR7.
CCR7 transcripts were minimally expressed in ex vivo and proliferating WC1(+)gammadelta T cells, a unique cell population with proinflammatory characteristics
the pattern of expression of CCR7 in different populations of porcine lymphocytes appears to be similar to that of human, highlighting the value of the pig as a useful animal model for biomedical studies.
Pre-translntation of sertli cell CCR7 significantly suppresses lymphocyte proliferation and prolongs allogeneic skin graft survival.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
C-C chemokine receptor type 7
, CC chemokine receptor 7
, chemokine (C-C motif) receptor 7 a
, chemokine (C-C motif) receptor 7
, c-C chemokine receptor type 7-like
, C-C CKR-7
, EBV-induced G-protein coupled receptor 1
, MIP-3 beta receptor
, chemokine (C-C) receptor 7
, epstein-Barr virus-induced G-protein coupled receptor 1
, EBV-induced G protein-coupled receptor 1
, Epstein-Barr virus induced G-protein coupled receptor
, Epstein-Barr virus induced gene 1
, lymphocyte-specific G protein-coupled peptide receptor
, chemokine receptor 7