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Kif13b also negatively regulates Dlg1 stability in oligodendrocytes, in which Dlg1, in contrast to Schwann cells, enhances AKT (show AKT1 Proteins) activation and promotes myelination
Dlg1 regulates p38 (show CRK Proteins)-dependent proinflammatory cytokine production.
phenotypes of Dlg1-/- mice involving cellular disorganization and insufficient tissue elongation strongly suggest a defect in the convergent extension movements
Loss of Dlg1 confers strong predisposition to the development of pediatric B-ALL in a murine model.
data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII (show CAMK2G Proteins) activation.
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling.
lack of the Dlg1 gene induces a decrease in apoptotic epithelial cell death and the persistence of the common nephric duct, which result in a dysfunctional vesicoureteral junction and cause megaureter or hydronephrosis through vesicoureteral reflux
DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret (show RET Proteins) expression, and apoptosis.
Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin (show PVALB Proteins) interneurons in the visual cortex in mice.
DLG1 and CASK (show CASK Proteins) play critical cooperative roles in maintaining the nephron progenitor population, potentially via a mechanism involving effects on FGF signaling
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.
Human papillomavirus oncoproteins E6 and E7 induce the loss of DLG1 from the cell borders and an increase in the level of DLG1 protein, reflecting the pattern observed in cervical lesions.
The study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processes.
Trans-homophilic interaction of CADM1 (show CADM1 Proteins) activates PI3K (show PIK3CA Proteins) by forming a complex with MAGuK-family proteins MPP3 (show MPP3 Proteins) and Dlg (show DLG4 Proteins).
the synapse-associated protein-97 (SAP97), an excitatory synapse scaffolding element, governs ADAM10 (show ADAM10 Proteins) trafficking from dendritic Golgi outposts to synaptic membranes, mediated by a previously uncharacterized protein kinase C.
E4-ORF1 (show NCKIPSD Proteins) interacts with Dlg1 and PI3K (show PIK3CA Proteins) to assemble a ternary complex where E4-ORF1 (show NCKIPSD Proteins) hijacks the Dlg1 oncogenic function to relocate cytoplasmic PI3K (show PIK3CA Proteins) to the membrane for constitutive activation.
While other domains of SAP97 were involved in forward trafficking of GluN1-3 out of the endoplasmic reticulum (ER), the SH3 domain was necessary and sufficient to block the ER retention.
DLG1, XIST, DDX3Y (show DDX3Y Proteins) and RPS4Y1 (show RPS4Y1 Proteins) genes can classify samples into different group clearly, and they are regarded as high confidence distinct gene biomarkers of Parkinson disease.
Novel genetic variants in the coding regions of DLG1 gene associated with susceptibility to Crohn's disease.
These findings indicate that most, if not all, human adenovirus E4-ORF1 (show NCKIPSD Proteins) proteins share a conserved molecular mechanism of PI3K (show PIK3CA Proteins) activation via Dlg1 binding and confer a common capacity to promote oncogenic transformation.
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
discs, large homolog 1 (Drosophila)
, synapse-associated protein 97
, disks large homolog 1
, Drosophila discs-large tumor suppressor homologue (synapse associated protein)
, embryo-dlg/synapse-associated protein 97
, presynaptic protein SAP97