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study shows that HA117 potentially promotes the stem-like signature of the HL60/ATRA cell line by inhibiting by the ubiquitination and degradation of DNMT1 (show DNMT1 ELISA Kits) and by down-regulating the expression of the GGL (show GGT5 ELISA Kits) domain of RGS6 (show RGS6 ELISA Kits)
genetic association studies on a population in Republic of Korea: Data suggest that an SNP in RGS6 (show RGS6 ELISA Kits) (rs2239219) is closely linked to stress-induced abdominal obesity in the population studied.
High RACGAP1 (show RACGAP1 ELISA Kits) expression is associated with Basal-like Breast Cancers.
Data support the notion that the Galpha (show SUCLG1 ELISA Kits), but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 (show TRPC4 ELISA Kits) activation and unveil new roles for RGS (show PITX2 ELISA Kits) and RGS6 (show RGS6 ELISA Kits) in fine-tuning TRPC4 (show TRPC4 ELISA Kits) activities.
Data suggest that MGCRABGAP is involved in mammalian spermiogenesis by modulating RAB10 (show RAB10 ELISA Kits).
This study showed that the overexpressions of Ki67 (show MKI67 ELISA Kits), RacGAP1 (show RACGAP1 ELISA Kits), and TOP2a (show TOP2A ELISA Kits) affect the prognosis of female breast cancer patients adversely
Data confirmed a strong correlation of AURKA (show AURKA ELISA Kits) and Wnt (show WNT2 ELISA Kits)-modulator RACGAP1 (show RACGAP1 ELISA Kits) gene expression both in the gastric tumor, the tumor-adjacent and the tumor-distant mucosa.
No significant association between SNPs of RGS6 (show RGS6 ELISA Kits) and central adiposity has been found.
RacGAP1 (show RACGAP1 ELISA Kits) Is a Novel Downstream Effector of E2F7 (show E2F7 ELISA Kits)-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
RACGAP1 (show RACGAP1 ELISA Kits) expression levels in the nucleus and cytoplasm, determined by immunohistochemical staining, predict opposite clinical outcomes and that both could be independent prognostic markers for colorectal cancer.
results indicate that, mTOR (show FRAP1 ELISA Kits), Bad, or Survivin (show BIRC5 ELISA Kits) are not required for p120 RasGAP fragment N to protect cells from cell death; conclude that downstream targets of Akt (show AKT1 ELISA Kits) other than mTORC1, Bad, or survivin (show BIRC5 ELISA Kits) mediate fragment N-induced protection or that several Akt (show AKT1 ELISA Kits) effectors can compensate for each other to induce the pro-survival fragment N-dependent responses
RASA1 (show RASA1 ELISA Kits) catalytic activity is essential for the function and development of lymphatic vessel valves.
These results indicate that the caspase-3 (show CASP3 ELISA Kits)/p120 RasGAP stress-sensing module impacts on carcinogen-induced liver cancer incidence but not sufficiently so as to affect overall survival.
Double-deficient RASA1 (show RASA1 ELISA Kits)-neurofibromin 1 (show NF1 ELISA Kits) mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 (show NOTCH1 ELISA Kits) gene.
Rasa1 (show RASA1 ELISA Kits) may have a role in pathogenesis of capillary malformation-arteriovenous malformation in a mouse model
Regulation of Rasa1 (show RASA1 ELISA Kits) translation by miR (show MLXIP ELISA Kits)-132 was seen in severed axons, demonstrating local function within the axon.
RASA1 (show RASA1 ELISA Kits) mutation is responsible for the aberrant lymphatic architecture and functional abnormalities, as visualized in the PKWS (show RASA1 ELISA Kits) subject and in the animal model.
MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA by repressing RAS p21 GTPase activating protein (show RASA1 ELISA Kits) 1 (RASA1 (show RASA1 ELISA Kits))
14-3-3 (show YWHAQ ELISA Kits) negatively regulates the RGC downstream of the PI3-kinase (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway
Caspase-3 (show CASP3 ELISA Kits) is a stress intensity sensor that controls cell fate by either initiating a RasGAP (show RASA1 ELISA Kits) cleavage-dependent cell resistance program or a cell suicide response mediated by akt (show AKT1 ELISA Kits).
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
GTPase activating protein
, male germ cell RacGap
, protein CYK4 homolg
, protein CYK4 homolog
, rac GTPase-activating protein 1
, GTPase-activating protein
, RAS p21 protein activator 1
, ras GTPase-activating protein 1