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maintaining high levels of Neph1 at the membrane using a podocyte cell line overexpressing chimeric Neph1 increased the ability of podocytes to resist PAN-induced injury and PAN-induced albumin (show ALB ELISA Kits) leakage
Neph1-CD adopts a global shape in solution, and its interaction with ZO-1 (show TJP1 ELISA Kits) involves multiple sites.
Localization of Neph1 to the podocyte cell membrane is altered in the presence of mutant Myo1c (show MYO1C ELISA Kits), and is actin dependent. Knockdown of Myo1c (show MYO1C ELISA Kits) inhibits Neph1 membrane localization. Neph1 is critical for the maintenance of glomerular function.
A striking finding in this study is the lack of contribution of NEPH1, NPHS1, and NPHS2 genes in 15 Asian families with steroid-resistant nephrotic syndrome.
common variants in LRRC7 (show LRRC7 ELISA Kits), KIRREL, NPHS2 and ACTN4 (show ACTN4 ELISA Kits) do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes
Neph1 but not nephrin (show NPHS1 ELISA Kits) specifically binds to adaptor protein Grb2 (show GRB2 ELISA Kits) and tyrosine kinase (show TXK ELISA Kits) Csk (show CSK ELISA Kits) in a phosphorylation-dependent manner.
Neph1-Nephrin (show NPHS1 ELISA Kits) proteins bind the Par3 (show F2RL2 ELISA Kits)-Par6 (show PARD6A ELISA Kits)-atypical protein kinase C (show PRKCZ ELISA Kits) (aPKC) complex to regulate podocyte cell polarity
tyrosine phosphorylation of Neph1 mediated by Fyn (show FYN ELISA Kits) results in significantly increased Neph1 and ZO-1 (show TJP1 ELISA Kits) binding, suggesting a critical role for Neph1 tyrosine phosphorylation in reorganizing the Neph1-ZO-1 (show TJP1 ELISA Kits) complex.
Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken.
Fyn (show FYN ELISA Kits) catalyzes Nephrin (show NPHS1 ELISA Kits) phosphorylation in podocyte detergent-resistant membrane fractions.
nephrin (show NPHS1 ELISA Kits) and Neph1 interact and have roles in glomerular permeability
In the adult brain, Neph1 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph1 is seen in dendritic shafts of pyramidal neurons.
Nephrin-Neph1 complex transduces phosphorylation-mediated signals that assemble an actin polymerization complex at the podocyte intercellular junction.
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2\; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003
, kin of IRRE-like protein 1
, kin of irregular chiasm-like protein 1
, nephrin-like protein 1
, kin of IRRE like 1
, nephrin 1